Chan Ho Kwon, Eva S Safaie, Jannell A Torres, Zhaohui Yang, Xi Chen, Young Dal Jang
{"title":"饲粮中添加维生素D3对断奶仔猪生长性能、血液维生素D状态和抗氧化能力的影响。","authors":"Chan Ho Kwon, Eva S Safaie, Jannell A Torres, Zhaohui Yang, Xi Chen, Young Dal Jang","doi":"10.5713/ab.25.0525","DOIUrl":null,"url":null,"abstract":"<p><strong>Objective: </strong>This study evaluated the effects of dietary vitamin D3 (VD₃) supplementation on growth performance, blood vitamin D, and antioxidant status in weaning pigs.</p><p><strong>Methods: </strong>Forty newly weaned piglets (6.02 ± 1.17 kg) were assigned to two treatments with five replicates over a 28-d period. Treatments were 1) NRC-VD3: NRC recommended levels [220 IU/kg in Phase 1 (d 0-14 postweaning) and 200 IU/kg in Phase 2 (d 14-28 postweaning)], and 2) High-VD₃: a high level of VD3 (2,000 IU/kg in Phase 1 and 2). Body weight, average daily gain, average daily feed intake and gain-to-feed ratio were measured weekly. Blood samples were collected at d 14 and 28 postweaning for the analyses of plasma 25-hydroxycholecalciferol (25-OHD₃), total antioxidant capacity (T-AOC), superoxide dismutase (SOD) activity, and malondialdehyde (MDA) levels. Pearson correlation coefficients between plasma 25-OHD₃ and SOD, MDA, or T-AOC were determined.</p><p><strong>Results: </strong>Growth performance did not differ in overall nursery period although feed intake was lower in the High-VD₃ group than the NRC-VD3 group in d 14-28 postweaning (p<0.05). Pigs fed High-VD₃ diets showed greater plasma 25-OHD₃ at d 14 and 28 postweaning (p<0.05), tended to have reduced plasma MDA (p = 0.06), and increased plasma SOD activity (p = 0.10) at d 14 postweaning compared with those fed NRC-VD3 diets with no effect in plasma T-AOC. At d 14 postweaning, plasma 25-OHD3 was positively correlated with plasma SOD activity (r = 0.532; p<0.05) and tended to be negatively correlated with plasma MDA levels (r = -0.491; p = 0.06).</p><p><strong>Conclusion: </strong>High VD₃ supplementation at 2,000 IU/kg did not enhance growth performance, while improving plasma vitamin D and antioxidant status in weaning pigs compared to NRC-level supplementation. Therefore, supplementing weaning pigs with higher-than-recommended levels of VD₃ could be beneficial to enhance their antioxidant status and overall health.</p>","PeriodicalId":7825,"journal":{"name":"Animal Bioscience","volume":" ","pages":""},"PeriodicalIF":2.5000,"publicationDate":"2025-10-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Effects of dietary vitamin D3 supplementation on growth performance, blood vitamin D status, and antioxidant capacity in weaning pigs.\",\"authors\":\"Chan Ho Kwon, Eva S Safaie, Jannell A Torres, Zhaohui Yang, Xi Chen, Young Dal Jang\",\"doi\":\"10.5713/ab.25.0525\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Objective: </strong>This study evaluated the effects of dietary vitamin D3 (VD₃) supplementation on growth performance, blood vitamin D, and antioxidant status in weaning pigs.</p><p><strong>Methods: </strong>Forty newly weaned piglets (6.02 ± 1.17 kg) were assigned to two treatments with five replicates over a 28-d period. Treatments were 1) NRC-VD3: NRC recommended levels [220 IU/kg in Phase 1 (d 0-14 postweaning) and 200 IU/kg in Phase 2 (d 14-28 postweaning)], and 2) High-VD₃: a high level of VD3 (2,000 IU/kg in Phase 1 and 2). Body weight, average daily gain, average daily feed intake and gain-to-feed ratio were measured weekly. Blood samples were collected at d 14 and 28 postweaning for the analyses of plasma 25-hydroxycholecalciferol (25-OHD₃), total antioxidant capacity (T-AOC), superoxide dismutase (SOD) activity, and malondialdehyde (MDA) levels. Pearson correlation coefficients between plasma 25-OHD₃ and SOD, MDA, or T-AOC were determined.</p><p><strong>Results: </strong>Growth performance did not differ in overall nursery period although feed intake was lower in the High-VD₃ group than the NRC-VD3 group in d 14-28 postweaning (p<0.05). Pigs fed High-VD₃ diets showed greater plasma 25-OHD₃ at d 14 and 28 postweaning (p<0.05), tended to have reduced plasma MDA (p = 0.06), and increased plasma SOD activity (p = 0.10) at d 14 postweaning compared with those fed NRC-VD3 diets with no effect in plasma T-AOC. At d 14 postweaning, plasma 25-OHD3 was positively correlated with plasma SOD activity (r = 0.532; p<0.05) and tended to be negatively correlated with plasma MDA levels (r = -0.491; p = 0.06).</p><p><strong>Conclusion: </strong>High VD₃ supplementation at 2,000 IU/kg did not enhance growth performance, while improving plasma vitamin D and antioxidant status in weaning pigs compared to NRC-level supplementation. Therefore, supplementing weaning pigs with higher-than-recommended levels of VD₃ could be beneficial to enhance their antioxidant status and overall health.</p>\",\"PeriodicalId\":7825,\"journal\":{\"name\":\"Animal Bioscience\",\"volume\":\" \",\"pages\":\"\"},\"PeriodicalIF\":2.5000,\"publicationDate\":\"2025-10-22\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Animal Bioscience\",\"FirstCategoryId\":\"97\",\"ListUrlMain\":\"https://doi.org/10.5713/ab.25.0525\",\"RegionNum\":2,\"RegionCategory\":\"农林科学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q1\",\"JCRName\":\"AGRICULTURE, DAIRY & ANIMAL SCIENCE\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Animal Bioscience","FirstCategoryId":"97","ListUrlMain":"https://doi.org/10.5713/ab.25.0525","RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"AGRICULTURE, DAIRY & ANIMAL SCIENCE","Score":null,"Total":0}
Effects of dietary vitamin D3 supplementation on growth performance, blood vitamin D status, and antioxidant capacity in weaning pigs.
Objective: This study evaluated the effects of dietary vitamin D3 (VD₃) supplementation on growth performance, blood vitamin D, and antioxidant status in weaning pigs.
Methods: Forty newly weaned piglets (6.02 ± 1.17 kg) were assigned to two treatments with five replicates over a 28-d period. Treatments were 1) NRC-VD3: NRC recommended levels [220 IU/kg in Phase 1 (d 0-14 postweaning) and 200 IU/kg in Phase 2 (d 14-28 postweaning)], and 2) High-VD₃: a high level of VD3 (2,000 IU/kg in Phase 1 and 2). Body weight, average daily gain, average daily feed intake and gain-to-feed ratio were measured weekly. Blood samples were collected at d 14 and 28 postweaning for the analyses of plasma 25-hydroxycholecalciferol (25-OHD₃), total antioxidant capacity (T-AOC), superoxide dismutase (SOD) activity, and malondialdehyde (MDA) levels. Pearson correlation coefficients between plasma 25-OHD₃ and SOD, MDA, or T-AOC were determined.
Results: Growth performance did not differ in overall nursery period although feed intake was lower in the High-VD₃ group than the NRC-VD3 group in d 14-28 postweaning (p<0.05). Pigs fed High-VD₃ diets showed greater plasma 25-OHD₃ at d 14 and 28 postweaning (p<0.05), tended to have reduced plasma MDA (p = 0.06), and increased plasma SOD activity (p = 0.10) at d 14 postweaning compared with those fed NRC-VD3 diets with no effect in plasma T-AOC. At d 14 postweaning, plasma 25-OHD3 was positively correlated with plasma SOD activity (r = 0.532; p<0.05) and tended to be negatively correlated with plasma MDA levels (r = -0.491; p = 0.06).
Conclusion: High VD₃ supplementation at 2,000 IU/kg did not enhance growth performance, while improving plasma vitamin D and antioxidant status in weaning pigs compared to NRC-level supplementation. Therefore, supplementing weaning pigs with higher-than-recommended levels of VD₃ could be beneficial to enhance their antioxidant status and overall health.
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