{"title":"肝纤维化的定量评估：加苯二胺增强MRI上B1不均匀校正的VFA T1定位。","authors":"Lianbang Wang, Hui Ma, Xiao Feng, Zijian Shen, Jin Cui, Ximing Wang, Gongzheng Wang, Xinya Zhao","doi":"10.2174/0115734056393310250929071043","DOIUrl":null,"url":null,"abstract":"<p><p>Accurate early diagnosis and assessment of liver fibrosis are important for patient treatment and prognosis. This study explored the value of Gd- BOPTA-enhanced T1 mapping via the B1 inhomogeneity-corrected Variable Flip Angle (VFA) method for staging liver fibrosis in rats.</p><p><strong>Methods: </strong>Sprague‒Dawley rats were divided into one control group (n = 6) and four carbon tetrachloride-induced liver fibrosis groups (n = 6 each group). T1 mapping via B1 inhomogeneity-corrected VFA was performed before and 90 minutes after Gd-BOPTA administration. Precontrast T1 values (T1<sub>pre</sub>), postcontrast T1 values (T1<sub>post</sub>), and the reduction rate of T1 values (ΔT1%) were quantified on T1 mapping images. The diagnostic performance was evaluated by the Area Under the Receiver Operating Characteristic Curve (AUC). The correlations between T1pre, T1post, ΔT1% values, and the expression levels of hepatocyte transporters (Oatp1a1 and Mrp2) were evaluated.</p><p><strong>Results: </strong>T1<sub>post</sub> and ΔT1% were significantly correlated with liver fibrosis stage (r = 0.832, p < 0.001; r = -0.798, p < 0.001, respectively), whereas T1<sub>pre</sub> was not significantly correlated with fibrosis stage (r = 0.357, p = 0.062). The AUCs of T1<sub>post</sub> and ΔT1% were greater than those of postcontrast signal intensity for diagnosing stages F2-F4 (0.936, 0.941 vs. 0.791; p = 0.043, 0.038, respectively), F3-F4 (0.928, 0.861 vs. 0.660; p = 0.003, 0.028, respectively) and F4 (0.965, 0.896 vs. 0.761; p = 0.021, 0.049, respectively). Oatp1a1 and Mrp2 expression levels correlated significantly with T1<sub>post</sub> (r = -0.859, p = 0.001; r = -0.697, p = 0.017) and ΔT1% (r = 0.891, p < 0.001; r = 0.685, p = 0.020), respectively.</p><p><strong>Discussion: </strong>T1<sub>post</sub> and ΔT1% were significantly correlated with liver fibrosis stages, and have good diagnostic performance for staging liver fibrosis. The protein expression levels of Oatp1a1 and Mrp2 correlated significantly with T1<sub>post</sub> and ΔT1%.</p><p><strong>Conclusion: </strong>Gd-BOPTA-enhanced T1 mapping via the B1 inhomogeneity-corrected VFA shows promise as a potentially accurate and reliable tool for quantifying liver fibrosis stages.</p>","PeriodicalId":54215,"journal":{"name":"Current Medical Imaging Reviews","volume":" ","pages":""},"PeriodicalIF":1.1000,"publicationDate":"2025-10-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Quantitative Assessment of Liver Fibrosis: B1 Inhomogeneity-Corrected VFA T1 Mapping on Gadobenate Dimeglumine-Enhanced MRI.\",\"authors\":\"Lianbang Wang, Hui Ma, Xiao Feng, Zijian Shen, Jin Cui, Ximing Wang, Gongzheng Wang, Xinya Zhao\",\"doi\":\"10.2174/0115734056393310250929071043\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p>Accurate early diagnosis and assessment of liver fibrosis are important for patient treatment and prognosis. This study explored the value of Gd- BOPTA-enhanced T1 mapping via the B1 inhomogeneity-corrected Variable Flip Angle (VFA) method for staging liver fibrosis in rats.</p><p><strong>Methods: </strong>Sprague‒Dawley rats were divided into one control group (n = 6) and four carbon tetrachloride-induced liver fibrosis groups (n = 6 each group). T1 mapping via B1 inhomogeneity-corrected VFA was performed before and 90 minutes after Gd-BOPTA administration. Precontrast T1 values (T1<sub>pre</sub>), postcontrast T1 values (T1<sub>post</sub>), and the reduction rate of T1 values (ΔT1%) were quantified on T1 mapping images. The diagnostic performance was evaluated by the Area Under the Receiver Operating Characteristic Curve (AUC). The correlations between T1pre, T1post, ΔT1% values, and the expression levels of hepatocyte transporters (Oatp1a1 and Mrp2) were evaluated.</p><p><strong>Results: </strong>T1<sub>post</sub> and ΔT1% were significantly correlated with liver fibrosis stage (r = 0.832, p < 0.001; r = -0.798, p < 0.001, respectively), whereas T1<sub>pre</sub> was not significantly correlated with fibrosis stage (r = 0.357, p = 0.062). The AUCs of T1<sub>post</sub> and ΔT1% were greater than those of postcontrast signal intensity for diagnosing stages F2-F4 (0.936, 0.941 vs. 0.791; p = 0.043, 0.038, respectively), F3-F4 (0.928, 0.861 vs. 0.660; p = 0.003, 0.028, respectively) and F4 (0.965, 0.896 vs. 0.761; p = 0.021, 0.049, respectively). Oatp1a1 and Mrp2 expression levels correlated significantly with T1<sub>post</sub> (r = -0.859, p = 0.001; r = -0.697, p = 0.017) and ΔT1% (r = 0.891, p < 0.001; r = 0.685, p = 0.020), respectively.</p><p><strong>Discussion: </strong>T1<sub>post</sub> and ΔT1% were significantly correlated with liver fibrosis stages, and have good diagnostic performance for staging liver fibrosis. The protein expression levels of Oatp1a1 and Mrp2 correlated significantly with T1<sub>post</sub> and ΔT1%.</p><p><strong>Conclusion: </strong>Gd-BOPTA-enhanced T1 mapping via the B1 inhomogeneity-corrected VFA shows promise as a potentially accurate and reliable tool for quantifying liver fibrosis stages.</p>\",\"PeriodicalId\":54215,\"journal\":{\"name\":\"Current Medical Imaging Reviews\",\"volume\":\" \",\"pages\":\"\"},\"PeriodicalIF\":1.1000,\"publicationDate\":\"2025-10-20\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Current Medical Imaging Reviews\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.2174/0115734056393310250929071043\",\"RegionNum\":4,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q3\",\"JCRName\":\"RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Current Medical Imaging Reviews","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.2174/0115734056393310250929071043","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING","Score":null,"Total":0}
引用次数: 0
摘要
准确的早期诊断和评估肝纤维化对患者的治疗和预后至关重要。本研究通过B1不均匀校正可变翻转角（VFA）方法探讨Gd- bopta增强T1映射在大鼠肝纤维化分期中的价值。方法：将Sprague-Dawley大鼠分为1个对照组（n = 6）和4个四氯化碳肝纤维化组（每组n = 6）。在Gd-BOPTA给药前和给药后90分钟，通过B1非均匀校正VFA进行T1定位。在T1映射图像上量化对比前T1值（T1pre）、对比后T1值（T1post）和T1值降低率（ΔT1%）。采用受者工作特征曲线下面积（AUC）评价诊断效果。评估T1pre， T1post， ΔT1%值与肝细胞转运蛋白（Oatp1a1和Mrp2）表达水平的相关性。结果：T1post、ΔT1%与肝纤维化分期有显著相关性（r = 0.832, p < 0.001; r = -0.798, p < 0.001）， T1pre与肝纤维化分期无显著相关性（r = 0.357, p = 0.062）。t1 - post、ΔT1%的auc均大于t2 -F4、t3 -F4（分别0.936、0.941、0.791,p = 0.043、0.038）、F4（分别0.928、0.861、0.660,p = 0.003、0.028）、F4（分别0.965、0.896、0.761,p = 0.021、0.049）。Oatp1a1和Mrp2的表达水平分别与T1post （r = -0.859, p = 0.001; r = -0.697, p = 0.017）和ΔT1% （r = 0.891, p < 0.001; r = 0.685, p = 0.020）呈显著相关。讨论：T1post和ΔT1%与肝纤维化分期有显著相关性，对肝纤维化分期有较好的诊断作用。Oatp1a1和Mrp2蛋白表达水平与T1post和ΔT1%显著相关。结论：gd - bopta通过B1不均匀校正的VFA增强T1定位，有望成为定量肝纤维化分期的潜在准确可靠的工具。
Quantitative Assessment of Liver Fibrosis: B1 Inhomogeneity-Corrected VFA T1 Mapping on Gadobenate Dimeglumine-Enhanced MRI.
Accurate early diagnosis and assessment of liver fibrosis are important for patient treatment and prognosis. This study explored the value of Gd- BOPTA-enhanced T1 mapping via the B1 inhomogeneity-corrected Variable Flip Angle (VFA) method for staging liver fibrosis in rats.
Methods: Sprague‒Dawley rats were divided into one control group (n = 6) and four carbon tetrachloride-induced liver fibrosis groups (n = 6 each group). T1 mapping via B1 inhomogeneity-corrected VFA was performed before and 90 minutes after Gd-BOPTA administration. Precontrast T1 values (T1pre), postcontrast T1 values (T1post), and the reduction rate of T1 values (ΔT1%) were quantified on T1 mapping images. The diagnostic performance was evaluated by the Area Under the Receiver Operating Characteristic Curve (AUC). The correlations between T1pre, T1post, ΔT1% values, and the expression levels of hepatocyte transporters (Oatp1a1 and Mrp2) were evaluated.
Results: T1post and ΔT1% were significantly correlated with liver fibrosis stage (r = 0.832, p < 0.001; r = -0.798, p < 0.001, respectively), whereas T1pre was not significantly correlated with fibrosis stage (r = 0.357, p = 0.062). The AUCs of T1post and ΔT1% were greater than those of postcontrast signal intensity for diagnosing stages F2-F4 (0.936, 0.941 vs. 0.791; p = 0.043, 0.038, respectively), F3-F4 (0.928, 0.861 vs. 0.660; p = 0.003, 0.028, respectively) and F4 (0.965, 0.896 vs. 0.761; p = 0.021, 0.049, respectively). Oatp1a1 and Mrp2 expression levels correlated significantly with T1post (r = -0.859, p = 0.001; r = -0.697, p = 0.017) and ΔT1% (r = 0.891, p < 0.001; r = 0.685, p = 0.020), respectively.
Discussion: T1post and ΔT1% were significantly correlated with liver fibrosis stages, and have good diagnostic performance for staging liver fibrosis. The protein expression levels of Oatp1a1 and Mrp2 correlated significantly with T1post and ΔT1%.
Conclusion: Gd-BOPTA-enhanced T1 mapping via the B1 inhomogeneity-corrected VFA shows promise as a potentially accurate and reliable tool for quantifying liver fibrosis stages.
期刊介绍：
Current Medical Imaging Reviews publishes frontier review articles, original research articles, drug clinical trial studies and guest edited thematic issues on all the latest advances on medical imaging dedicated to clinical research. All relevant areas are covered by the journal, including advances in the diagnosis, instrumentation and therapeutic applications related to all modern medical imaging techniques.
The journal is essential reading for all clinicians and researchers involved in medical imaging and diagnosis.
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