杜氏肌营养不良患者鼻吸入压力（SNIP）的多参数分析：一项健康受试者的病例对照研究

IF 2.3 3区医学 Q1 PEDIATRICS

Pediatric Pulmonology Pub Date : 2025-10-01 DOI:10.1002/ppul.71344

Ilsa P Santos, Layana Marques, Jessica D M da Fonseca, Mario E Dourado, Matías Otto-Yáñez, Rodrigo Torres-Castro, Francesca Pennati, Andrea Aliverti, Guilherme A F Fregonezi, Vanessa R Resqueti

{"title":"杜氏肌营养不良患者鼻吸入压力（SNIP）的多参数分析：一项健康受试者的病例对照研究","authors":"Ilsa P Santos, Layana Marques, Jessica D M da Fonseca, Mario E Dourado, Matías Otto-Yáñez, Rodrigo Torres-Castro, Francesca Pennati, Andrea Aliverti, Guilherme A F Fregonezi, Vanessa R Resqueti","doi":"10.1002/ppul.71344","DOIUrl":null,"url":null,"abstract":"Background: Individuals with Duchenne Muscular Dystrophy (DMD) exhibit respiratory muscle changes leading to fatigue and weakness, and assessing relaxation rates and contractile properties may help detect early fatigue.Aim: To non-invasively assess inspiratory muscle relaxation and contractile rates using sniff nasal inspiratory pressure (SNIP) parameters in DMD subjects and compare them with matched healthy controls.Methods: A case-control study of 32 DMD male subjects and 32 age-matched healthy controls (12.7 ± 5.1 years). All subjects underwent spirometry, maximal respiratory pressures, and SNIP test. We calculated the maximum relaxation rate (MRR), decay constant (τ), and maximum rate of pressure development (MRPD) from the SNIP curve.Results: The DMD group had significantly lower MRR (5.9 [5.1-6.9] vs. 8 [6.9-10.3] %/ms, p = 0.001), lower MRPD (-0.38 [-0.47 to -0.26] vs. -0.62 [-0.52 to -0.80] cmH2O/ms-1, p = 0.001), and higher τ (65.7 [50.7-78.1] vs. 40.5 [30.2-48.7] ms, p = 0.001). ROC curves showed that SNIP parameters effectively distinguish DMD from healthy subjects (SNIP [AUC 0.94, p < 0.001], MRR [AUC 0.86, p < 0.001], τ [AUC 0.92, p < 0.001], and MRPD [AUC 0.89, p < 0.001]).Conclusions: DMD subjects show impaired inspiratory muscle contraction and relaxation, indicating early muscle weakness or fatigue. SNIP-derived parameters may help in the early identification of inspiratory muscle dysfunction in DMD, potentially contributing to clinical detection and intervention.","PeriodicalId":19932,"journal":{"name":"Pediatric Pulmonology","volume":"60 10","pages":"e71344"},"PeriodicalIF":2.3000,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Multiparametric Analysis of Nasal Inspiratory Pressure (SNIP) in Duchenne Muscular Dystrophy: A Case-Control Study With Healthy Subjects.\",\"authors\":\"Ilsa P Santos, Layana Marques, Jessica D M da Fonseca, Mario E Dourado, Matías Otto-Yáñez, Rodrigo Torres-Castro, Francesca Pennati, Andrea Aliverti, Guilherme A F Fregonezi, Vanessa R Resqueti\",\"doi\":\"10.1002/ppul.71344\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"Background: Individuals with Duchenne Muscular Dystrophy (DMD) exhibit respiratory muscle changes leading to fatigue and weakness, and assessing relaxation rates and contractile properties may help detect early fatigue.Aim: To non-invasively assess inspiratory muscle relaxation and contractile rates using sniff nasal inspiratory pressure (SNIP) parameters in DMD subjects and compare them with matched healthy controls.Methods: A case-control study of 32 DMD male subjects and 32 age-matched healthy controls (12.7 ± 5.1 years). All subjects underwent spirometry, maximal respiratory pressures, and SNIP test. We calculated the maximum relaxation rate (MRR), decay constant (τ), and maximum rate of pressure development (MRPD) from the SNIP curve.Results: The DMD group had significantly lower MRR (5.9 [5.1-6.9] vs. 8 [6.9-10.3] %/ms, p = 0.001), lower MRPD (-0.38 [-0.47 to -0.26] vs. -0.62 [-0.52 to -0.80] cmH2O/ms-1, p = 0.001), and higher τ (65.7 [50.7-78.1] vs. 40.5 [30.2-48.7] ms, p = 0.001). ROC curves showed that SNIP parameters effectively distinguish DMD from healthy subjects (SNIP [AUC 0.94, p < 0.001], MRR [AUC 0.86, p < 0.001], τ [AUC 0.92, p < 0.001], and MRPD [AUC 0.89, p < 0.001]).Conclusions: DMD subjects show impaired inspiratory muscle contraction and relaxation, indicating early muscle weakness or fatigue. SNIP-derived parameters may help in the early identification of inspiratory muscle dysfunction in DMD, potentially contributing to clinical detection and intervention.\",\"PeriodicalId\":19932,\"journal\":{\"name\":\"Pediatric Pulmonology\",\"volume\":\"60 10\",\"pages\":\"e71344\"},\"PeriodicalIF\":2.3000,\"publicationDate\":\"2025-10-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Pediatric Pulmonology\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.1002/ppul.71344\",\"RegionNum\":3,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q1\",\"JCRName\":\"PEDIATRICS\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Pediatric Pulmonology","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1002/ppul.71344","RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"PEDIATRICS","Score":null,"Total":0}

引用次数: 0

摘要

背景：患有杜氏肌营养不良症（DMD）的个体表现出导致疲劳和虚弱的呼吸肌变化，评估松弛率和收缩特性可能有助于发现早期疲劳。目的：利用鼻吸气压（SNIP）参数无创评估DMD患者的吸气肌松弛率和收缩率，并与健康对照进行比较。方法：对32名DMD男性受试者和32名年龄匹配的健康对照（12.7±5.1岁）进行病例对照研究。所有受试者均进行肺活量测定、最大呼吸压和SNIP测试。我们计算了SNIP曲线的最大弛豫速率（MRR）、衰减常数（τ）和最大压力发展速率（MRPD）。结果：DMD组MRR显著降低（5.9 [5.1-6.9]vs. 8 [6.9-10.3] %/ms, p = 0.001）， MRPD显著降低（-0.38 [-0.47 - -0.26]vs. -0.62 [-0.52 - -0.80] cmH2O/ms-1, p = 0.001）， τ显著升高（65.7 [50.7-78.1]vs. 40.5 [30.2-48.7] ms, p = 0.001）。ROC曲线显示SNIP参数能有效区分DMD与健康受试者（SNIP [AUC 0.94, p]）。结论：DMD受试者吸气肌收缩舒张受损，提示早期肌肉无力或疲劳。snipp衍生的参数可能有助于早期识别DMD患者的吸气肌功能障碍，可能有助于临床检测和干预。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

查看原文本刊更多论文

Multiparametric Analysis of Nasal Inspiratory Pressure (SNIP) in Duchenne Muscular Dystrophy: A Case-Control Study With Healthy Subjects.

Background: Individuals with Duchenne Muscular Dystrophy (DMD) exhibit respiratory muscle changes leading to fatigue and weakness, and assessing relaxation rates and contractile properties may help detect early fatigue.

Aim: To non-invasively assess inspiratory muscle relaxation and contractile rates using sniff nasal inspiratory pressure (SNIP) parameters in DMD subjects and compare them with matched healthy controls.

Methods: A case-control study of 32 DMD male subjects and 32 age-matched healthy controls (12.7 ± 5.1 years). All subjects underwent spirometry, maximal respiratory pressures, and SNIP test. We calculated the maximum relaxation rate (MRR), decay constant (τ), and maximum rate of pressure development (MRPD) from the SNIP curve.

Results: The DMD group had significantly lower MRR (5.9 [5.1-6.9] vs. 8 [6.9-10.3] %/ms, p = 0.001), lower MRPD (-0.38 [-0.47 to -0.26] vs. -0.62 [-0.52 to -0.80] cmH₂O/ms-1, p = 0.001), and higher τ (65.7 [50.7-78.1] vs. 40.5 [30.2-48.7] ms, p = 0.001). ROC curves showed that SNIP parameters effectively distinguish DMD from healthy subjects (SNIP [AUC 0.94, p < 0.001], MRR [AUC 0.86, p < 0.001], τ [AUC 0.92, p < 0.001], and MRPD [AUC 0.89, p < 0.001]).

Conclusions: DMD subjects show impaired inspiratory muscle contraction and relaxation, indicating early muscle weakness or fatigue. SNIP-derived parameters may help in the early identification of inspiratory muscle dysfunction in DMD, potentially contributing to clinical detection and intervention.

求助全文

通过发布文献求助，成功后即可免费获取论文全文。去求助

来源期刊

Pediatric Pulmonology 医学-呼吸系统

CiteScore

6.00

自引率

12.90%

发文量

468

审稿时长

3-8 weeks

期刊介绍： Pediatric Pulmonology (PPUL) is the foremost global journal studying the respiratory system in disease and in health as it develops from intrauterine life though adolescence to adulthood. Combining explicit and informative analysis of clinical as well as basic scientific research, PPUL provides a look at the many facets of respiratory system disorders in infants and children, ranging from pathological anatomy, developmental issues, and pathophysiology to infectious disease, asthma, cystic fibrosis, and airborne toxins. Focused attention is given to the reporting of diagnostic and therapeutic methods for neonates, preschool children, and adolescents, the enduring effects of childhood respiratory diseases, and newly described infectious diseases. PPUL concentrates on subject matters of crucial interest to specialists preparing for the Pediatric Subspecialty Examinations in the United States and other countries. With its attentive coverage and extensive clinical data, this journal is a principle source for pediatricians in practice and in training and a must have for all pediatric pulmonologists.