ATG9协助脂质补充，促进溶酶体膜修复。

IF 8.7 1区生物学 Q1 CELL BIOLOGY

Developmental cell Pub Date : 2025-10-20 DOI:10.1016/j.devcel.2025.09.010

Hemmo Meyer, Bojana Kravic

引用次数: 0

摘要

溶酶体膜可在各种条件下渗透，对细胞造成有害后果。在这期杂志上，de Tito等人报道了脂质超燃酶ATG9，其在自噬体形成中的作用最为人所知，它有助于内质网脂质的分布，从而重新封闭限制膜，恢复溶酶体的功能。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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ATG9 assists lipid replenishment for lysosome membrane repair.

Lysosomal membranes can be permeabilized under various conditions with detrimental consequences for the cell. In this issue, de Tito et al. report that the lipid scramblase ATG9, best known for its role in autophagosome formation, helps distribute lipids from the ER to reseal the limiting membrane and restore lysosomal function.

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来源期刊

Developmental cell 生物-发育生物学

CiteScore

18.90

自引率

1.70%

发文量

203

审稿时长

3-6 weeks

期刊介绍： Developmental Cell, established in 2001, is a comprehensive journal that explores a wide range of topics in cell and developmental biology. Our publication encompasses work across various disciplines within biology, with a particular emphasis on investigating the intersections between cell biology, developmental biology, and other related fields. Our primary objective is to present research conducted through a cell biological perspective, addressing the essential mechanisms governing cell function, cellular interactions, and responses to the environment. Moreover, we focus on understanding the collective behavior of cells, culminating in the formation of tissues, organs, and whole organisms, while also investigating the consequences of any malfunctions in these intricate processes.