Xueqin Li, Wanyu Zhao, Huirong Zheng, Bangshan Liu, Hongbo He, Jin Liu, Ling Jiang Li, Yan Zhang
{"title":"中国中老年妇女的生物学和社会生殖因素与晚年认知功能。","authors":"Xueqin Li, Wanyu Zhao, Huirong Zheng, Bangshan Liu, Hongbo He, Jin Liu, Ling Jiang Li, Yan Zhang","doi":"10.1002/alz.70824","DOIUrl":null,"url":null,"abstract":"<div>\n \n \n <section>\n \n <h3> INTRODUCTION</h3>\n \n <p>Few studies have concurrently examined the biological and social reproductive factors in relation to women's cognitive aging.</p>\n </section>\n \n <section>\n \n <h3> METHODS</h3>\n \n <p>We analyzed 8577 women and 7872 men ≥45 years of age from the China Health and Retirement Longitudinal Study. Biological reproductive factors included reproductive span, age at menarche, and age at menopause; social reproductive factors included number of children and age at first live birth. Multivariable regression models were sequentially adjusted for age, childhood cognition proxy, education, and current health and lifestyle factors.</p>\n </section>\n \n <section>\n \n <h3> RESULTS</h3>\n \n <p>Longer reproductive span was associated with better cognitive performance in women, whereas a higher number of children were linked to poorer cognition in both sexes, particularly in women. These associations remained robust after full adjustment, compared with age at menarche, age at menopause, and age at first birth.</p>\n </section>\n \n <section>\n \n <h3> CONCLUSION</h3>\n \n <p>Integrating biological and social reproductive factors provides insights into sex-specific cognitive aging patterns and may inform tailored dementia prevention strategies.</p>\n </section>\n \n <section>\n \n <h3> Highlights</h3>\n \n <div>\n <ul>\n \n <li>A longer reproductive span was linked to better cognition in older Chinese women.</li>\n \n <li>More children were linked to poorer cognition in both sexes, especially in women.</li>\n \n <li>Reproductive span and number of children showed robust associations with late-life cognition, stronger than other reproductive factors.</li>\n </ul>\n </div>\n </section>\n </div>","PeriodicalId":7471,"journal":{"name":"Alzheimer's & Dementia","volume":"21 10","pages":""},"PeriodicalIF":11.1000,"publicationDate":"2025-10-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12541285/pdf/","citationCount":"0","resultStr":"{\"title\":\"Biological and social reproductive factors and late-life cognitive function in middle-aged and older Chinese women\",\"authors\":\"Xueqin Li, Wanyu Zhao, Huirong Zheng, Bangshan Liu, Hongbo He, Jin Liu, Ling Jiang Li, Yan Zhang\",\"doi\":\"10.1002/alz.70824\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div>\\n \\n \\n <section>\\n \\n <h3> INTRODUCTION</h3>\\n \\n <p>Few studies have concurrently examined the biological and social reproductive factors in relation to women's cognitive aging.</p>\\n </section>\\n \\n <section>\\n \\n <h3> METHODS</h3>\\n \\n <p>We analyzed 8577 women and 7872 men ≥45 years of age from the China Health and Retirement Longitudinal Study. Biological reproductive factors included reproductive span, age at menarche, and age at menopause; social reproductive factors included number of children and age at first live birth. Multivariable regression models were sequentially adjusted for age, childhood cognition proxy, education, and current health and lifestyle factors.</p>\\n </section>\\n \\n <section>\\n \\n <h3> RESULTS</h3>\\n \\n <p>Longer reproductive span was associated with better cognitive performance in women, whereas a higher number of children were linked to poorer cognition in both sexes, particularly in women. These associations remained robust after full adjustment, compared with age at menarche, age at menopause, and age at first birth.</p>\\n </section>\\n \\n <section>\\n \\n <h3> CONCLUSION</h3>\\n \\n <p>Integrating biological and social reproductive factors provides insights into sex-specific cognitive aging patterns and may inform tailored dementia prevention strategies.</p>\\n </section>\\n \\n <section>\\n \\n <h3> Highlights</h3>\\n \\n <div>\\n <ul>\\n \\n <li>A longer reproductive span was linked to better cognition in older Chinese women.</li>\\n \\n <li>More children were linked to poorer cognition in both sexes, especially in women.</li>\\n \\n <li>Reproductive span and number of children showed robust associations with late-life cognition, stronger than other reproductive factors.</li>\\n </ul>\\n </div>\\n </section>\\n </div>\",\"PeriodicalId\":7471,\"journal\":{\"name\":\"Alzheimer's & Dementia\",\"volume\":\"21 10\",\"pages\":\"\"},\"PeriodicalIF\":11.1000,\"publicationDate\":\"2025-10-22\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12541285/pdf/\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Alzheimer's & Dementia\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://alz-journals.onlinelibrary.wiley.com/doi/10.1002/alz.70824\",\"RegionNum\":1,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q1\",\"JCRName\":\"CLINICAL NEUROLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Alzheimer's & Dementia","FirstCategoryId":"3","ListUrlMain":"https://alz-journals.onlinelibrary.wiley.com/doi/10.1002/alz.70824","RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"CLINICAL NEUROLOGY","Score":null,"Total":0}
Biological and social reproductive factors and late-life cognitive function in middle-aged and older Chinese women
INTRODUCTION
Few studies have concurrently examined the biological and social reproductive factors in relation to women's cognitive aging.
METHODS
We analyzed 8577 women and 7872 men ≥45 years of age from the China Health and Retirement Longitudinal Study. Biological reproductive factors included reproductive span, age at menarche, and age at menopause; social reproductive factors included number of children and age at first live birth. Multivariable regression models were sequentially adjusted for age, childhood cognition proxy, education, and current health and lifestyle factors.
RESULTS
Longer reproductive span was associated with better cognitive performance in women, whereas a higher number of children were linked to poorer cognition in both sexes, particularly in women. These associations remained robust after full adjustment, compared with age at menarche, age at menopause, and age at first birth.
CONCLUSION
Integrating biological and social reproductive factors provides insights into sex-specific cognitive aging patterns and may inform tailored dementia prevention strategies.
Highlights
A longer reproductive span was linked to better cognition in older Chinese women.
More children were linked to poorer cognition in both sexes, especially in women.
Reproductive span and number of children showed robust associations with late-life cognition, stronger than other reproductive factors.
期刊介绍：
Alzheimer's & Dementia is a peer-reviewed journal that aims to bridge knowledge gaps in dementia research by covering the entire spectrum, from basic science to clinical trials to social and behavioral investigations. It provides a platform for rapid communication of new findings and ideas, optimal translation of research into practical applications, increasing knowledge across diverse disciplines for early detection, diagnosis, and intervention, and identifying promising new research directions. In July 2008, Alzheimer's & Dementia was accepted for indexing by MEDLINE, recognizing its scientific merit and contribution to Alzheimer's research.
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