索拉非尼羟基肟衍生物生物活性的设计、合成和评价。

IF 2 4区生物学 Q4 CELL BIOLOGY

Acta Naturae Pub Date : 2025-07-01 DOI:10.32607/actanaturae.27566

A A Kleymenova, I A Abramov, Ya V Tkachev, P S Galeeva, V A Kleymenova, N F Zakirova, S N Kochetkov, M V Kozlov

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引用次数: 0

摘要

索拉非尼是一种多酪氨酸激酶抑制剂，用于治疗肝癌和肾癌。我们合成了含有锌依赖性组蛋白去乙酰化酶抑制剂药效团元素的索拉非尼羟肟衍生物。我们发现合成的杂化抑制剂对癌细胞增殖的抑制主要依赖于“去乙酰化酶”元素的结构。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

The Design, Synthesis, and Evaluation of the Biological Activity of Hydroxamic Derivatives of Sorafenib.

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The Design, Synthesis, and Evaluation of the Biological Activity of Hydroxamic Derivatives of Sorafenib.

Sorafenib is a multiple tyrosine kinase inhibitor that is used in the treatment of liver and renal cancers. We synthesized the hydroxamic derivatives of sorafenib bearing the pharmacophore elements of zinc-dependent histone deacetylase inhibitors. We uncovered that suppression of cancer cell proliferation by the synthesized hybrid inhibitors critically depends on the structure of the "deacetylase" element.

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来源期刊

Acta Naturae 农林科学-林学

CiteScore

3.50

自引率

5.00%

发文量

审稿时长

>12 weeks

期刊介绍： Acta Naturae is an international journal on life sciences based in Moscow, Russia. Our goal is to present scientific work and discovery in molecular biology, biochemistry, biomedical disciplines and biotechnology. These fields represent the most important priorities for the research and engineering development both in Russia and worldwide. Acta Naturae is also a periodical for those who are curious in various aspects of biotechnological business, innovations in pharmaceutical areas, intellectual property protection and social consequences of scientific progress. The journal publishes analytical industrial surveys focused on the development of different spheres of modern life science and technology. Being a radically new and totally unique journal in Russia, Acta Naturae is useful to both representatives of fundamental research and experts in applied sciences.