{"title":"基于有机声敏剂的SDT与增强ROS生成。","authors":"Qianyun Shan, Rumei Li, Bin Ying, Wei Zhu, Xiaojin Wu, Shouxing Xu, Xuanxuan Zhang, Zhikang Xu, Xinyue Zhu, Weiyu Chen, Kai Zhang, Jian Chen","doi":"10.1016/j.ultsonch.2025.107625","DOIUrl":null,"url":null,"abstract":"<p><p>Organic sonosensitizer-based sonodynamic therapy (SDT) is an emerging, non-invasive strategy for cancer treatment, leveraging ultrasound (US) activation to trigger reactive oxygen species (ROS) production and induce tumor cell apoptosis. However, the clinical translation of SDT is limited by two key factors: the intrinsically low ROS quantum yield of many organic sonosensitizers and the hypoxic tumor microenvironment (TME), which restricts O<sub>2</sub>-dependent ROS generation. This review systematically examines recent molecular design strategies aimed at enhancing ROS production, including heavy atom incorporation, donor-acceptor (D-A) architecture design, π-conjugation extension, and solubility modulation. Furthermore, we evaluated innovative O<sub>2</sub>-delivery/generation tumor reoxygenation approaches for enhanced SDT, such as O<sub>2</sub>-nanocarriers, in-situ catalytic O<sub>2</sub> generation, and mitochondrial respiration modulation etc. Notably, integrating clinically validated sonosensitizers like porphyrins with translational O<sub>2</sub>-delivery systems such as perfluorocarbon (PFC) nanoemulsions or vascular normalization, offers a synergistic strategy to overcome tumor hypoxia, amplify ROS generation, and unlock the full therapeutic potential of SDT in future clinical applications.</p>","PeriodicalId":442,"journal":{"name":"Ultrasonics Sonochemistry","volume":"122 ","pages":"107625"},"PeriodicalIF":9.7000,"publicationDate":"2025-10-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Organic Sonosensitizers-based SDT with enhanced ROS generation.\",\"authors\":\"Qianyun Shan, Rumei Li, Bin Ying, Wei Zhu, Xiaojin Wu, Shouxing Xu, Xuanxuan Zhang, Zhikang Xu, Xinyue Zhu, Weiyu Chen, Kai Zhang, Jian Chen\",\"doi\":\"10.1016/j.ultsonch.2025.107625\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p>Organic sonosensitizer-based sonodynamic therapy (SDT) is an emerging, non-invasive strategy for cancer treatment, leveraging ultrasound (US) activation to trigger reactive oxygen species (ROS) production and induce tumor cell apoptosis. However, the clinical translation of SDT is limited by two key factors: the intrinsically low ROS quantum yield of many organic sonosensitizers and the hypoxic tumor microenvironment (TME), which restricts O<sub>2</sub>-dependent ROS generation. This review systematically examines recent molecular design strategies aimed at enhancing ROS production, including heavy atom incorporation, donor-acceptor (D-A) architecture design, π-conjugation extension, and solubility modulation. Furthermore, we evaluated innovative O<sub>2</sub>-delivery/generation tumor reoxygenation approaches for enhanced SDT, such as O<sub>2</sub>-nanocarriers, in-situ catalytic O<sub>2</sub> generation, and mitochondrial respiration modulation etc. Notably, integrating clinically validated sonosensitizers like porphyrins with translational O<sub>2</sub>-delivery systems such as perfluorocarbon (PFC) nanoemulsions or vascular normalization, offers a synergistic strategy to overcome tumor hypoxia, amplify ROS generation, and unlock the full therapeutic potential of SDT in future clinical applications.</p>\",\"PeriodicalId\":442,\"journal\":{\"name\":\"Ultrasonics Sonochemistry\",\"volume\":\"122 \",\"pages\":\"107625\"},\"PeriodicalIF\":9.7000,\"publicationDate\":\"2025-10-15\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Ultrasonics Sonochemistry\",\"FirstCategoryId\":\"92\",\"ListUrlMain\":\"https://doi.org/10.1016/j.ultsonch.2025.107625\",\"RegionNum\":1,\"RegionCategory\":\"化学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q1\",\"JCRName\":\"ACOUSTICS\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Ultrasonics Sonochemistry","FirstCategoryId":"92","ListUrlMain":"https://doi.org/10.1016/j.ultsonch.2025.107625","RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"ACOUSTICS","Score":null,"Total":0}
Organic Sonosensitizers-based SDT with enhanced ROS generation.
Organic sonosensitizer-based sonodynamic therapy (SDT) is an emerging, non-invasive strategy for cancer treatment, leveraging ultrasound (US) activation to trigger reactive oxygen species (ROS) production and induce tumor cell apoptosis. However, the clinical translation of SDT is limited by two key factors: the intrinsically low ROS quantum yield of many organic sonosensitizers and the hypoxic tumor microenvironment (TME), which restricts O2-dependent ROS generation. This review systematically examines recent molecular design strategies aimed at enhancing ROS production, including heavy atom incorporation, donor-acceptor (D-A) architecture design, π-conjugation extension, and solubility modulation. Furthermore, we evaluated innovative O2-delivery/generation tumor reoxygenation approaches for enhanced SDT, such as O2-nanocarriers, in-situ catalytic O2 generation, and mitochondrial respiration modulation etc. Notably, integrating clinically validated sonosensitizers like porphyrins with translational O2-delivery systems such as perfluorocarbon (PFC) nanoemulsions or vascular normalization, offers a synergistic strategy to overcome tumor hypoxia, amplify ROS generation, and unlock the full therapeutic potential of SDT in future clinical applications.
期刊介绍：
Ultrasonics Sonochemistry stands as a premier international journal dedicated to the publication of high-quality research articles primarily focusing on chemical reactions and reactors induced by ultrasonic waves, known as sonochemistry. Beyond chemical reactions, the journal also welcomes contributions related to cavitation-induced events and processing, including sonoluminescence, and the transformation of materials on chemical, physical, and biological levels.
Since its inception in 1994, Ultrasonics Sonochemistry has consistently maintained a top ranking in the "Acoustics" category, reflecting its esteemed reputation in the field. The journal publishes exceptional papers covering various areas of ultrasonics and sonochemistry. Its contributions are highly regarded by both academia and industry stakeholders, demonstrating its relevance and impact in advancing research and innovation.
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