设计具有非典型钙晶体结构的脂质纳米颗粒用于增强ifn β介导的免疫治疗（Adv. Mater. 42/2025）

IF 26.8 1区材料科学 Q1 CHEMISTRY, MULTIDISCIPLINARY

Advanced Materials Pub Date : 2025-10-23 DOI:10.1002/adma.70844

Yujie Luo, Chuanda Zhu, Xuefei Guo, Yunfei Xie, Yu Sun, Dan Lu, Yufei Xia, Zhiqiang Lin, Fuping You

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引用次数: 0

摘要

ifn β介导的免疫治疗在他们的研究文章(DOI: 10.1002/adma。202419870)，夏玉飞，林志强，游富平等人发现了一种纳米材料含磷酸钙脂质体（NanoCa），其具有松散的内部结构和无定形晶体组成，可以通过溶酶体途径快速释放钙离子。NanoCa激活骨髓来源的树突状细胞中的IFNβ，作为连接抗原呈递和抗肿瘤作用的“桥梁”，跨越各种肿瘤模型。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

Engineering a Lipid Nanoparticle with Atypical Calcium Crystal Structure for Enhanced IFNβ-Mediated Immunotherapy (Adv. Mater. 42/2025)

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Engineering a Lipid Nanoparticle with Atypical Calcium Crystal Structure for Enhanced IFNβ-Mediated Immunotherapy (Adv. Mater. 42/2025)

IFNβ-Mediated Immunotherapy

In their Research Article (DOI: 10.1002/adma.202419870), Yufei Xia, Zhiqiang Lin, Fuping You, and co-workers identify a nanomaterial calcium phosphate-containing liposome (NanoCa), which exhibits a loose internal structure and an amorphous crystalline composition, enabling rapid calcium ion release via the lysosomal pathway. NanoCa activates IFNβ in bone marrow-derived dendritic cells, serving as a “bridge” that links antigen presentation to anti-tumor effects across various tumor models.

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来源期刊

Advanced Materials 工程技术-材料科学：综合

CiteScore

43.00

自引率

4.10%

发文量

2182

审稿时长

2 months

期刊介绍： Advanced Materials, one of the world's most prestigious journals and the foundation of the Advanced portfolio, is the home of choice for best-in-class materials science for more than 30 years. Following this fast-growing and interdisciplinary field, we are considering and publishing the most important discoveries on any and all materials from materials scientists, chemists, physicists, engineers as well as health and life scientists and bringing you the latest results and trends in modern materials-related research every week.