Himanshu Sekhar Panda, Mrunali D. Dhokne, Sumit Thakur, Nisha Singh, Ashok Kumar Datusalia, Jiban Jyoti Panda
{"title":"BDNF负载氨基酸-儿茶酚胺混合纳米颗粒治疗阿尔茨海默病认知能力下降（Small 42/2025）","authors":"Himanshu Sekhar Panda, Mrunali D. Dhokne, Sumit Thakur, Nisha Singh, Ashok Kumar Datusalia, Jiban Jyoti Panda","doi":"10.1002/smll.70723","DOIUrl":null,"url":null,"abstract":"<p><b>Alzheimer's Disease</b></p><p>BDNF-loaded amino acid–catecholamine hybrid nanoparticles (B-EDTNPs) are capable of crossing the blood–brain barrier (BBB) to efficiently deliver BDNF. These nanoparticles inhibit Aβ fibrillization, promote amyloid plaque clearance, reduce oxidative stress, and protect neuronal cells from fibril-induced damage. In SH-SY5Y neuroblastoma cells, B-EDTNPs significantly improve cell viability against FF and Aβ (1-42) toxicity. Promising outcomes in AD mouse model are shown by effectively reducing amyloid plaque accumulation, suppress inflammatory markers like NF-κB and TNF-α, and restore cognitive functions. More in article number 2411701, Ashok Kumar Datusalia, Jiban Jyoti Panda, and co-workers.\n\n <figure>\n <div><picture>\n <source></source></picture><p></p>\n </div>\n </figure></p>","PeriodicalId":228,"journal":{"name":"Small","volume":"21 42","pages":""},"PeriodicalIF":12.1000,"publicationDate":"2025-10-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/smll.70723","citationCount":"0","resultStr":"{\"title\":\"BDNF Loaded Amino Acid-Catecholamine Hybrid Nanoparticles as Curative Agents Against Cognitive Decline in Alzheimer's Disease (Small 42/2025)\",\"authors\":\"Himanshu Sekhar Panda, Mrunali D. Dhokne, Sumit Thakur, Nisha Singh, Ashok Kumar Datusalia, Jiban Jyoti Panda\",\"doi\":\"10.1002/smll.70723\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><b>Alzheimer's Disease</b></p><p>BDNF-loaded amino acid–catecholamine hybrid nanoparticles (B-EDTNPs) are capable of crossing the blood–brain barrier (BBB) to efficiently deliver BDNF. These nanoparticles inhibit Aβ fibrillization, promote amyloid plaque clearance, reduce oxidative stress, and protect neuronal cells from fibril-induced damage. In SH-SY5Y neuroblastoma cells, B-EDTNPs significantly improve cell viability against FF and Aβ (1-42) toxicity. Promising outcomes in AD mouse model are shown by effectively reducing amyloid plaque accumulation, suppress inflammatory markers like NF-κB and TNF-α, and restore cognitive functions. More in article number 2411701, Ashok Kumar Datusalia, Jiban Jyoti Panda, and co-workers.\\n\\n <figure>\\n <div><picture>\\n <source></source></picture><p></p>\\n </div>\\n </figure></p>\",\"PeriodicalId\":228,\"journal\":{\"name\":\"Small\",\"volume\":\"21 42\",\"pages\":\"\"},\"PeriodicalIF\":12.1000,\"publicationDate\":\"2025-10-23\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://onlinelibrary.wiley.com/doi/epdf/10.1002/smll.70723\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Small\",\"FirstCategoryId\":\"88\",\"ListUrlMain\":\"https://onlinelibrary.wiley.com/doi/10.1002/smll.70723\",\"RegionNum\":2,\"RegionCategory\":\"材料科学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q1\",\"JCRName\":\"CHEMISTRY, MULTIDISCIPLINARY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Small","FirstCategoryId":"88","ListUrlMain":"https://onlinelibrary.wiley.com/doi/10.1002/smll.70723","RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"CHEMISTRY, MULTIDISCIPLINARY","Score":null,"Total":0}
BDNF Loaded Amino Acid-Catecholamine Hybrid Nanoparticles as Curative Agents Against Cognitive Decline in Alzheimer's Disease (Small 42/2025)
Alzheimer's Disease
BDNF-loaded amino acid–catecholamine hybrid nanoparticles (B-EDTNPs) are capable of crossing the blood–brain barrier (BBB) to efficiently deliver BDNF. These nanoparticles inhibit Aβ fibrillization, promote amyloid plaque clearance, reduce oxidative stress, and protect neuronal cells from fibril-induced damage. In SH-SY5Y neuroblastoma cells, B-EDTNPs significantly improve cell viability against FF and Aβ (1-42) toxicity. Promising outcomes in AD mouse model are shown by effectively reducing amyloid plaque accumulation, suppress inflammatory markers like NF-κB and TNF-α, and restore cognitive functions. More in article number 2411701, Ashok Kumar Datusalia, Jiban Jyoti Panda, and co-workers.
期刊介绍：
Small serves as an exceptional platform for both experimental and theoretical studies in fundamental and applied interdisciplinary research at the nano- and microscale. The journal offers a compelling mix of peer-reviewed Research Articles, Reviews, Perspectives, and Comments.
With a remarkable 2022 Journal Impact Factor of 13.3 (Journal Citation Reports from Clarivate Analytics, 2023), Small remains among the top multidisciplinary journals, covering a wide range of topics at the interface of materials science, chemistry, physics, engineering, medicine, and biology.
Small's readership includes biochemists, biologists, biomedical scientists, chemists, engineers, information technologists, materials scientists, physicists, and theoreticians alike.
求助内容：
应助结果提醒方式：
京公网安备 11010802042870号
