MouseOmics：用于小鼠生物学研究的多组学数据库。

IF 13.1 2区生物学 Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY

Nucleic Acids Research Pub Date : 2025-10-21 DOI:10.1093/nar/gkaf1031

Xin Tian,Yifan Teng,Miaomiao Huang,Qian Zhang,Juan Huang,Yong Chen,Ao Wu,Qishan Wang,Jingyin Yu,Jie Feng

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引用次数: 0

摘要

小鼠是医学和生命科学中重要的模型和不可缺少的资源，广泛用于发育生物学和多组学研究。然而，一个全面的、集成的小鼠多组学数据库仍然缺乏。本研究通过整合分布于鼠属5个物种的21个基因组、584个组织样本的转录组、285个组织样本的蛋白质组、143个组织样本的代谢组、296个组织样本的金属组以及52个小鼠近交系的3个变异，建立了小鼠多组学数据库MouseOmics。所有的鼠标多组学数据都可以通过多个功能模块进行挖掘，具有友好的web界面。此外，我们嵌入了一些有用的工具，如MISAweb，用于微卫星dna的鉴定，并专门开发了InterPro， Gene Ontology和Pathway的小鼠富集分析模块。鼠标多组学数据可以方便地在线下载。MouseOmics将定期更新最新发布的鼠标多组学数据，并可通过地址https://www.varnatech.cn/MouseOmics免费访问。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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MouseOmics: a multi-omics database for mouse biological study.

Mouse represents a pivotal model and indispensable resource in medical and life sciences, widely used for developmental biology and multi-omics studies. Yet, a comprehensive, integrated mouse multi-omics database remains lacking. Here, we established a mouse multi-omics database, MouseOmics, by integrating 21 genomes distributed among five species within the genus Mus, transcriptomes in 584 tissue samples, proteomes in 285 tissue samples, metabolomes in 143 tissue samples, metallomes in 296 tissue samples, and three variomes covering 52 mouse inbred strains. All mouse multi-omics data can be explored through multiple functional modules with user-friendly web interface. Furthermore, we embedded several useful tools, like MISAweb, for the identification of microsatellite DNAs, and specifically developed the enrichment analysis modules of InterPro, Gene Ontology, and Pathway for mouse. The mouse multi-omics data can be downloaded online conveniently. MouseOmics will be updated regularly with the newly released mouse multi-omics data and can be accessed freely via the address https://www.varnatech.cn/MouseOmics.

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来源期刊

Nucleic Acids Research 生物-生化与分子生物学

CiteScore

27.10

自引率

4.70%

发文量

1057

审稿时长

2 months

期刊介绍： Nucleic Acids Research (NAR) is a scientific journal that publishes research on various aspects of nucleic acids and proteins involved in nucleic acid metabolism and interactions. It covers areas such as chemistry and synthetic biology, computational biology, gene regulation, chromatin and epigenetics, genome integrity, repair and replication, genomics, molecular biology, nucleic acid enzymes, RNA, and structural biology. The journal also includes a Survey and Summary section for brief reviews. Additionally, each year, the first issue is dedicated to biological databases, and an issue in July focuses on web-based software resources for the biological community. Nucleic Acids Research is indexed by several services including Abstracts on Hygiene and Communicable Diseases, Animal Breeding Abstracts, Agricultural Engineering Abstracts, Agbiotech News and Information, BIOSIS Previews, CAB Abstracts, and EMBASE.