一种用于声动力治疗的新型锌（II）复合物诱导乳腺癌细胞焦亡并增强抗肿瘤免疫反应。

IF 14.1 1区材料科学 Q1 CHEMISTRY, MULTIDISCIPLINARY

Advanced Science Pub Date : 2025-10-21 DOI:10.1002/advs.202508155

Sijie Wen, Dongsheng Tang, Lingpu Zhang, Hanchen Zhang, Zheng Cao, Kong Wai Tan, Xiaojun Wang, Haihua Xiao, Kun Shang

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引用次数: 0

摘要

锌（II）配合物因其良好的生物安全性和生物相容性而成为有前景的抗肿瘤药物，并在光动力治疗（PDT）中显示出有效性。然而，它们的治疗潜力受到PDT药物组织渗透能力差的限制。本文介绍了一种用于声动力治疗（SDT）的新型锌（II）配合物，该配合物能够在超声激活后产生大量的单线态氧。该声敏剂能有效诱导乳腺癌细胞焦亡，显著促进抗肿瘤免疫反应。这项工作代表了锌（II）复合物在SDT中的首次探索，为提高乳腺癌治疗效果建立了新的途径。

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A Novel Zinc(II) Complex for Sonodynamic Therapy Induces Pyroptosis of Breast Cancer Cells and Enhances Anti-Tumor Immune Response.

Zinc(II) complexes have emerged as promising antitumor agents due to their favorable biosafety and biocompatibility, and demonstrated effectiveness in photodynamic therapy (PDT). However, their therapeutic potential is limited by the poor tissue penetration of PDT agents. Herein, a novel zinc(II) complex designed for sonodynamic therapy (SDT), capable of producing substantial amounts of singlet oxygen upon ultrasonic activation, is introduced. This sonosensitizer effectively induces pyroptosis in breast cancer cells, significantly promoting the antitumor immune response. This work represents the first exploration of zinc(II) complexes in SDT, establishing a new avenue for enhanced therapeutic outcomes against breast cancer.

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来源期刊

Advanced Science CHEMISTRY, MULTIDISCIPLINARYNANOSCIENCE &-NANOSCIENCE & NANOTECHNOLOGY

CiteScore

18.90

自引率

2.60%

发文量

1602

审稿时长

1.9 months

期刊介绍： Advanced Science is a prestigious open access journal that focuses on interdisciplinary research in materials science, physics, chemistry, medical and life sciences, and engineering. The journal aims to promote cutting-edge research by employing a rigorous and impartial review process. It is committed to presenting research articles with the highest quality production standards, ensuring maximum accessibility of top scientific findings. With its vibrant and innovative publication platform, Advanced Science seeks to revolutionize the dissemination and organization of scientific knowledge.