三氟甲基芳烃脱氟偶联立体选择性合成氟烯基和炔烃。

IF 16.9 1区化学 Q1 CHEMISTRY, MULTIDISCIPLINARY

Angewandte Chemie International Edition Pub Date : 2025-10-20 DOI:10.1002/anie.202515710

José L Rosario-Collazo,Courtney Westlund,Hawa Keita,Simon J Meek

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引用次数: 0

摘要

公开了一种通过芳基三氟甲基的去氟/ C-C偶联立体选择性合成三取代和四取代1,2-氟溴代烯烃和炔的实用方法。在路易斯碱活化剂的存在下，转化将简单的丰富的cf3 -芳烃和多功能有机二硼试剂转化为偶联产物，收率高达94%，Z/E选择性为bbb98:2。通过几个产品转换来强调合成效用，这些产品转换可以访问一系列不同的支架。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Stereoselective Synthesis of Alkenyl Fluorides and Alkynes by Defluoro Coupling of Trifluoromethyl Arenes.

A practical method for the stereoselective synthesis of tri- and tetra-substituted 1,2-fluoro-borylalkenes and alkynes by defluoro / C-C coupling of aryl trifluoromethyl groups is disclosed. Transformations convert simple abundant CF3-arenes and multifunctional organodiboron reagents in the presence of a Lewis base activator into coupled products in up to 94% yield and >98:2 Z/E selectivity. Synthetic utility is highlighted by several product transformations that access an array of diverse scaffolds.

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来源期刊

Angewandte Chemie International Edition 化学-化学综合

CiteScore

26.60

自引率

6.60%

发文量

3549

审稿时长

1.5 months

期刊介绍： Angewandte Chemie, a journal of the German Chemical Society (GDCh), maintains a leading position among scholarly journals in general chemistry with an impressive Impact Factor of 16.6 (2022 Journal Citation Reports, Clarivate, 2023). Published weekly in a reader-friendly format, it features new articles almost every day. Established in 1887, Angewandte Chemie is a prominent chemistry journal, offering a dynamic blend of Review-type articles, Highlights, Communications, and Research Articles on a weekly basis, making it unique in the field.