{"title":"牙间充质干细胞（DMSCs）在口腔颌面部缺损修复中的应用","authors":"Yiqi Chen, Xikun Ma, Huaqing Mai, Pengyu Lai, Renlong Huang, Adili Alimujiang","doi":"10.3389/fbioe.2025.1677422","DOIUrl":null,"url":null,"abstract":"<p><p>Dental mesenchymal stem cells (DMSCs) are important seed cells for oral and maxillofacial tissue regeneration due to their wide availability, multi-directional differentiation potential, strong proliferation ability, maintenance of stemness after multiple proliferations, and immunomodulatory capacity. DMSCs have a wide range of sources, and different subtypes have different properties. They can promote tissue regeneration through direct differentiation into tissue cells, improvement of the local regeneration microenvironment through immunomodulatory functions, and release of various bioactive components. The article reviews the classification of DMSCs, their performance comparisons in recent years, methods of promoting tissue regeneration, and their applications in maxillofacial bone and soft tissue. Furthermore, the review explores DMSCs' excellent abilities to promote bone tissue repair when supported by various materials and repair maxillofacial soft tissue defects by promoting the regeneration of special structures of teeth such as dentin, cementum, and dental pulp vessels and nerves.</p>","PeriodicalId":12444,"journal":{"name":"Frontiers in Bioengineering and Biotechnology","volume":"13 ","pages":"1677422"},"PeriodicalIF":4.8000,"publicationDate":"2025-10-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12531237/pdf/","citationCount":"0","resultStr":"{\"title\":\"The application of dental mesenchymal stem cells (DMSCs) in the repair of oral and maxillofacial defects.\",\"authors\":\"Yiqi Chen, Xikun Ma, Huaqing Mai, Pengyu Lai, Renlong Huang, Adili Alimujiang\",\"doi\":\"10.3389/fbioe.2025.1677422\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p>Dental mesenchymal stem cells (DMSCs) are important seed cells for oral and maxillofacial tissue regeneration due to their wide availability, multi-directional differentiation potential, strong proliferation ability, maintenance of stemness after multiple proliferations, and immunomodulatory capacity. DMSCs have a wide range of sources, and different subtypes have different properties. They can promote tissue regeneration through direct differentiation into tissue cells, improvement of the local regeneration microenvironment through immunomodulatory functions, and release of various bioactive components. The article reviews the classification of DMSCs, their performance comparisons in recent years, methods of promoting tissue regeneration, and their applications in maxillofacial bone and soft tissue. Furthermore, the review explores DMSCs' excellent abilities to promote bone tissue repair when supported by various materials and repair maxillofacial soft tissue defects by promoting the regeneration of special structures of teeth such as dentin, cementum, and dental pulp vessels and nerves.</p>\",\"PeriodicalId\":12444,\"journal\":{\"name\":\"Frontiers in Bioengineering and Biotechnology\",\"volume\":\"13 \",\"pages\":\"1677422\"},\"PeriodicalIF\":4.8000,\"publicationDate\":\"2025-10-03\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12531237/pdf/\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Frontiers in Bioengineering and Biotechnology\",\"FirstCategoryId\":\"5\",\"ListUrlMain\":\"https://doi.org/10.3389/fbioe.2025.1677422\",\"RegionNum\":3,\"RegionCategory\":\"工程技术\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"2025/1/1 0:00:00\",\"PubModel\":\"eCollection\",\"JCR\":\"Q1\",\"JCRName\":\"BIOTECHNOLOGY & APPLIED MICROBIOLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Frontiers in Bioengineering and Biotechnology","FirstCategoryId":"5","ListUrlMain":"https://doi.org/10.3389/fbioe.2025.1677422","RegionNum":3,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2025/1/1 0:00:00","PubModel":"eCollection","JCR":"Q1","JCRName":"BIOTECHNOLOGY & APPLIED MICROBIOLOGY","Score":null,"Total":0}
The application of dental mesenchymal stem cells (DMSCs) in the repair of oral and maxillofacial defects.
Dental mesenchymal stem cells (DMSCs) are important seed cells for oral and maxillofacial tissue regeneration due to their wide availability, multi-directional differentiation potential, strong proliferation ability, maintenance of stemness after multiple proliferations, and immunomodulatory capacity. DMSCs have a wide range of sources, and different subtypes have different properties. They can promote tissue regeneration through direct differentiation into tissue cells, improvement of the local regeneration microenvironment through immunomodulatory functions, and release of various bioactive components. The article reviews the classification of DMSCs, their performance comparisons in recent years, methods of promoting tissue regeneration, and their applications in maxillofacial bone and soft tissue. Furthermore, the review explores DMSCs' excellent abilities to promote bone tissue repair when supported by various materials and repair maxillofacial soft tissue defects by promoting the regeneration of special structures of teeth such as dentin, cementum, and dental pulp vessels and nerves.
期刊介绍：
The translation of new discoveries in medicine to clinical routine has never been easy. During the second half of the last century, thanks to the progress in chemistry, biochemistry and pharmacology, we have seen the development and the application of a large number of drugs and devices aimed at the treatment of symptoms, blocking unwanted pathways and, in the case of infectious diseases, fighting the micro-organisms responsible. However, we are facing, today, a dramatic change in the therapeutic approach to pathologies and diseases. Indeed, the challenge of the present and the next decade is to fully restore the physiological status of the diseased organism and to completely regenerate tissue and organs when they are so seriously affected that treatments cannot be limited to the repression of symptoms or to the repair of damage. This is being made possible thanks to the major developments made in basic cell and molecular biology, including stem cell science, growth factor delivery, gene isolation and transfection, the advances in bioengineering and nanotechnology, including development of new biomaterials, biofabrication technologies and use of bioreactors, and the big improvements in diagnostic tools and imaging of cells, tissues and organs.
In today`s world, an enhancement of communication between multidisciplinary experts, together with the promotion of joint projects and close collaborations among scientists, engineers, industry people, regulatory agencies and physicians are absolute requirements for the success of any attempt to develop and clinically apply a new biological therapy or an innovative device involving the collective use of biomaterials, cells and/or bioactive molecules. “Frontiers in Bioengineering and Biotechnology” aspires to be a forum for all people involved in the process by bridging the gap too often existing between a discovery in the basic sciences and its clinical application.
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