人工栽培灵芝子实体中异芳醚键的羊毛甾烷-甲基萜偶联物及一种羊毛甾烷二聚体

IF 4.3 3区化学 Q2 CHEMISTRY, MULTIDISCIPLINARY

ACS Omega Pub Date : 2025-10-12 DOI:10.1021/acsomega.5c06826

Malipan Sappan, , , Panida Chinthanom, , , Kitlada Srichomthong, , , Tuksaporn Thummarukcharoen, , , Rattaket Choeyklin, , , Aphidech Sangdee, , and , Masahiko Isaka*,

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引用次数: 0

摘要

从培养的灵芝（菌株TBRC-BCC 22084）中分离到10个先前未描述的化合物，包括8个羊毛甾烷-二萜缀合物，ganohochimins a - h(1-8)，一种羊毛甾烷二聚体，ganohochimate a(9)和一种牛油萜类化合物，fornicin F（10）。ganohochimin A(1)的24s构型是通过在酸性条件下裂解芳基醚确定的。通过碱法水解，确定了甘诺氨基酸A(9)的结构。Ganohochimins对NCI-H187（小细胞肺癌）细胞（IC50为7.7 ~ 33 μM）和non - cancerous Vero细胞（IC50为6.3 ~ 30 μM）表现出细胞毒性。

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Lanostane–Meroterpene Conjugates with Unusual Aryl Ether Linkage and a Lanostane Dimer from Artificially Cultivated Fruiting Bodies of Ganoderma cf. hochiminhense

Ten previously undescribed compounds, including eight lanostane–meroterpene conjugates, ganohochimins A–H (1–8), a lanostane dimer, ganohochimate A (9), and a meroterpenoid, fornicin F (10), were isolated from the cultivated mushroom Ganoderma cf. hochiminhense(strain TBRC-BCC 22084). The 24S-configuration of ganohochimin A (1) was determined by cleavage of the aryl ether under acidic conditions. The structure of ganohochimate A (9) was confirmed by alkaline hydrolysis to cleave into two lanostane units. Ganohochimins exhibited cytotoxicity against NCI-H187 (small-cell lung cancer) cells (IC₅₀ 7.7–33 μM) and noncancerous Vero cells (IC₅₀ 6.3–30 μM).

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来源期刊

ACS Omega Chemical Engineering-General Chemical Engineering

CiteScore

6.60

自引率

4.90%

发文量

3945

审稿时长

2.4 months

期刊介绍： ACS Omega is an open-access global publication for scientific articles that describe new findings in chemistry and interfacing areas of science, without any perceived evaluation of immediate impact.