我们一圈又一圈地说：磷酸烯醇丙酮酸羧激酶1 （PCK1）与糖尿病、线粒体和肾脏健康有关。

IF 12.6 1区医学 Q1 UROLOGY & NEPHROLOGY

Kidney international Pub Date : 2025-10-17 DOI:10.1016/j.kint.2025.08.006

Mitchell A. Sullivan , Josephine M. Forbes

{"title":"我们一圈又一圈地说：磷酸烯醇丙酮酸羧激酶1 （PCK1）与糖尿病、线粒体和肾脏健康有关。","authors":"Mitchell A. Sullivan , Josephine M. Forbes","doi":"10.1016/j.kint.2025.08.006","DOIUrl":null,"url":null,"abstract":"<div><div>The kidneys require high levels of adenosine triphosphate production, rendering them particularly vulnerable to conditions that perturb mitochondrial function. A deficiency in phosphoenolpyruvate carboxykinase 1, a pivotal enzyme in central carbon metabolism, increases susceptibility to kidney injury, highlighting its importance in kidney health. Given phosphoenolpyruvate carboxykinase 1’s central metabolic location in gluconeogenic and tricarboxylic acid cycle flux pathways, isolating the mechanism by which phosphoenolpyruvate carboxykinase 1 protection occurs remains complex. A recent study, however, claims that its role in cataplerosis may be the key.</div></div>","PeriodicalId":17801,"journal":{"name":"Kidney international","volume":"108 5","pages":"Pages 738-740"},"PeriodicalIF":12.6000,"publicationDate":"2025-10-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Round and round we go: phosphoenolpyruvate carboxykinase 1 (PCK1) in cataplerosis, mitochondrial, and kidney health\",\"authors\":\"Mitchell A. Sullivan , Josephine M. Forbes\",\"doi\":\"10.1016/j.kint.2025.08.006\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><div>The kidneys require high levels of adenosine triphosphate production, rendering them particularly vulnerable to conditions that perturb mitochondrial function. A deficiency in phosphoenolpyruvate carboxykinase 1, a pivotal enzyme in central carbon metabolism, increases susceptibility to kidney injury, highlighting its importance in kidney health. Given phosphoenolpyruvate carboxykinase 1’s central metabolic location in gluconeogenic and tricarboxylic acid cycle flux pathways, isolating the mechanism by which phosphoenolpyruvate carboxykinase 1 protection occurs remains complex. A recent study, however, claims that its role in cataplerosis may be the key.</div></div>\",\"PeriodicalId\":17801,\"journal\":{\"name\":\"Kidney international\",\"volume\":\"108 5\",\"pages\":\"Pages 738-740\"},\"PeriodicalIF\":12.6000,\"publicationDate\":\"2025-10-17\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Kidney international\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S0085253825006635\",\"RegionNum\":1,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q1\",\"JCRName\":\"UROLOGY & NEPHROLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Kidney international","FirstCategoryId":"3","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S0085253825006635","RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"UROLOGY & NEPHROLOGY","Score":null,"Total":0}

引用次数: 0

摘要

肾脏需要高水平的三磷酸腺苷生成，这使得它们特别容易受到线粒体功能紊乱的影响。磷酸烯醇丙酮酸羧激酶1是中心碳代谢的关键酶，缺乏会增加肾损伤的易感性，突出了它在肾脏健康中的重要性。鉴于磷酸烯醇丙酮酸羧激酶1在糖异生和三羧酸循环通量途径中的中心代谢位置，分离磷酸烯醇丙酮酸羧激酶1保护作用的机制仍然很复杂。然而，最近的一项研究声称，它在突变中的作用可能是关键。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

查看原文本刊更多论文

Round and round we go: phosphoenolpyruvate carboxykinase 1 (PCK1) in cataplerosis, mitochondrial, and kidney health

The kidneys require high levels of adenosine triphosphate production, rendering them particularly vulnerable to conditions that perturb mitochondrial function. A deficiency in phosphoenolpyruvate carboxykinase 1, a pivotal enzyme in central carbon metabolism, increases susceptibility to kidney injury, highlighting its importance in kidney health. Given phosphoenolpyruvate carboxykinase 1’s central metabolic location in gluconeogenic and tricarboxylic acid cycle flux pathways, isolating the mechanism by which phosphoenolpyruvate carboxykinase 1 protection occurs remains complex. A recent study, however, claims that its role in cataplerosis may be the key.

求助全文

通过发布文献求助，成功后即可免费获取论文全文。去求助

来源期刊

Kidney international 医学-泌尿学与肾脏学

CiteScore

23.30

自引率

3.10%

发文量

490

审稿时长

3-6 weeks

期刊介绍： Kidney International (KI), the official journal of the International Society of Nephrology, is led by Dr. Pierre Ronco (Paris, France) and stands as one of nephrology's most cited and esteemed publications worldwide. KI provides exceptional benefits for both readers and authors, featuring highly cited original articles, focused reviews, cutting-edge imaging techniques, and lively discussions on controversial topics. The journal is dedicated to kidney research, serving researchers, clinical investigators, and practicing nephrologists.