focus作为口腔潜在恶性疾病和口腔鳞状细胞癌的生物标志物：系统综述和荟萃分析。

IF 2.1 4区医学 Q2 DENTISTRY, ORAL SURGERY & MEDICINE

Archives of oral biology Pub Date : 2025-10-14 DOI:10.1016/j.archoralbio.2025.106423

Shruti Gupta , Deepti Sharma , Anita Hooda , Mala Kamboj

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引用次数: 0

摘要

目的：本系统综述和荟萃分析旨在探讨病灶作为口腔潜在恶性疾病（OPMDs）和口腔鳞状细胞癌（OSCC）生物标志物的潜力。设计：在多个数据库中检索相关文章，包括PubMed、Scopus、谷歌Scholar、Science Direct和Clinical Key。23项符合资格标准的研究被纳入定性评价；其中，有20项研究提供了实验组与对照组比较的数据，进一步进行meta分析。结果：与健康对照组相比，OPMD患者（p = 0.013）和OSCC患者（p = 0.003）唾液中的病灶水平显著升高。此外，OSCC患者血清中的病灶水平升高（p ）。结论：本荟萃分析结果表明，病灶可作为opmd和OSCC的潜在生物标志物。然而，在血清评估中存在显著的异质性和有限的研究集中在唾液表明需要进一步的研究。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Fucose as a biomarker in oral potentially malignant disorders and oral squamous cell carcinoma: A systematic review and meta-analysis

Objectives

This systematic review and meta-analysis aimed to investigate the potential of fucose as a biomarker for oral potentially malignant disorders (OPMDs) and oral squamous cell carcinoma (OSCC).

Design

Relevant articles were searched across multiple databases, including PubMed, Scopus, Google Scholar, Science Direct, and Clinical Key. Twenty-three studies that met the eligibility criteria were included for qualitative review; out of which, 20 studies that provided data for comparison between study and control groups were further subjected to meta-analysis.

Results

The analysis revealed significantly high fucose levels in the saliva of OPMD patients (p = 0.013) and OSCC patients (p = 0.003) compared to healthy controls. Additionally, fucose levels were elevated in the serum of patients with OSCC (p < 0.001) and oral leukoplakia (p = 0.027) compared to controls.

Conclusion

The findings of this meta-analysis suggest that fucose could serve as a potential biomarker for OPMDs and OSCC. However, the presence of significant heterogeneity in serum evaluation and the limited studies focusing on saliva indicate the need for further investigation.

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来源期刊

Archives of oral biology 医学-牙科与口腔外科

CiteScore

5.10

自引率

3.30%

发文量

177

审稿时长

26 days

期刊介绍： Archives of Oral Biology is an international journal which aims to publish papers of the highest scientific quality in the oral and craniofacial sciences. The journal is particularly interested in research which advances knowledge in the mechanisms of craniofacial development and disease, including: Cell and molecular biology Molecular genetics Immunology Pathogenesis Cellular microbiology Embryology Syndromology Forensic dentistry