家庭运动训练对绝经后2型糖尿病妇女肠道菌群的影响及其与认知功能和代谢健康的可能关系：一项随机对照试验

IF 7.4 3区医学 Q1 ENDOCRINOLOGY & METABOLISM

Diabetes research and clinical practice Pub Date : 2025-10-17 DOI:10.1016/j.diabres.2025.112908

A. Vahed , M. Molanouri Shamsi , S.D. Siadat , M. Behmanesh , R. Negaresh , S. Agh-Mohammadi , M. Ebrahimi

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引用次数: 0

摘要

目的：有证据表明肠道微生物群与2型糖尿病（T2DM）有关。本研究调查了绝经后T2DM妇女在进行为期12周的家庭多任务运动干预后，肠道微生物群组成、认知功能和代谢健康之间的关系。方法：70名绝经后T2DM妇女被随机分配到干预组和对照组，干预组进行以家庭为基础的多任务练习。在干预前后评估肠道微生物群、认知功能、身体健康和代谢指标。结果：运动训练显著增加嗜粘杆菌和Faecalibacterium水平，降低乳酸杆菌丰度（p ）。结论：本研究支持多任务运动计划在改善绝经后T2DM妇女身体健康和代谢健康方面的潜在有效性。研究结果还表明，肠道和大脑之间可能存在联系，嗜粘液阿克曼氏菌可能是一种潜在的介质。研究akkermansia到大脑的通路代表了一个有前途的新兴研究领域，值得进一步探索。

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Effects of home-based exercise training on gut microbiota and possible relations with cognitive function and metabolic health in postmenopausal women with type 2 diabetes mellitus: a randomized control trial

Aim

Evidence suggests that the gut microbiome is involved in type 2 diabetes mellitus (T2DM). This study investigates the association between gut microbiota composition, cognitive function, and metabolic health in postmenopausal women with T2DM following a 12-week home-based multi-task exercise intervention.

Methods

Seventy postmenopausal women with T2DM were randomly assigned to either an intervention group, which performed home-based multi-task exercises, or a control group. Gut microbiota, cognitive function, physical fitness, and metabolic indices were assessed before and after the intervention.

Results

Exercise training significantly increased Akkermansia muciniphila and Faecalibacterium levels, and reduced Lactobacillus abundance (p < 0.05). Participants showed improvements in HDL levels, cognitive function, and physical fitness (p < 0.05). Among the microbial changes, an increased abundance of Akkermansia was significantly correlated with improvements in high-density lipoprotein (HDL) levels (r = 0.41) and cognitive function (r = 0.49).

Conclusion

This study supports the potential effectiveness of multi-task exercise programs in enhancing physical fitness and metabolic health in postmenopausal women with T2DM. The findings also suggest a possible connection between the gut and the brain, with Akkermansia muciniphila emerging as a potential mediator. Investigating the Akkermansia-to-brain pathway represents a promising and emerging area of research that warrants further exploration.

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来源期刊

Diabetes research and clinical practice 医学-内分泌学与代谢

CiteScore

10.30

自引率

3.90%

发文量

862

审稿时长

32 days

期刊介绍： Diabetes Research and Clinical Practice is an international journal for health-care providers and clinically oriented researchers that publishes high-quality original research articles and expert reviews in diabetes and related areas. The role of the journal is to provide a venue for dissemination of knowledge and discussion of topics related to diabetes clinical research and patient care. Topics of focus include translational science, genetics, immunology, nutrition, psychosocial research, epidemiology, prevention, socio-economic research, complications, new treatments, technologies and therapy.