揭示IL-41：多肌炎和皮肌炎诊断的新生物标志物。

IF 3.7 3区医学 Q2 BIOCHEMISTRY & MOLECULAR BIOLOGY

Cytokine Pub Date : 2025-10-17 DOI:10.1016/j.cyto.2025.157058

Zhi Li , Wen Qin , Xiudi Wu , Mingcai Li , Yan Li

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引用次数: 0

摘要

背景：多发性肌炎（PM）和皮肌炎（DM）是特发性炎症性肌病（IIM）的两种常见亚型。PM/DM患者血清白细胞介素(IL)-41的浓度未见报道。本研究旨在探讨诊断为PM/DM的个体血清中IL-41的水平。方法：共纳入118名参与者，包括80名PM/DM患者和38名健康对照（HC）。通过体格检查和详细的临床病史收集了每位参与者的全面临床资料。采用酶联免疫吸附法（ELISA）定量测定IL-41水平。采用Spearman相关分析检测IL-41水平与各临床参数的关系。采用受试者工作特征（ROC）曲线评估IL-41的诊断潜力。结果：PM/DM合并间质性肺疾病（ILD）患者血清IL-41水平明显高于HC [1001.03 (572.95, 1604.83) pg/mL vs 361.03 (302.24, 541.06) pg/mL, P]。结论：本研究显示PM/DM患者血清IL-41水平升高，提示IL-41可作为鉴别这些疾病的一种新的生物标志物。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

Unveiling IL-41: A novel biomarker for polymyositis and dermatomyositis diagnosis

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Unveiling IL-41: A novel biomarker for polymyositis and dermatomyositis diagnosis

Background: Polymyositis (PM) and dermatomyositis (DM) are two common subtypes of idiopathic inflammatory myopathies (IIM). The concentration of serum interleukin (IL)-41 in patients with PM/DM has not been reported. This study aims to investigate the levels of IL-41 in the serum of individuals diagnosed with PM/DM.

Methods: A total of 118 participants were enrolled in the study, comprising 80 patients with PM/DM and 38 healthy controls (HC). Comprehensive clinical data for each participant were collected through physical examinations and detailed clinical histories. The levels of IL-41 were quantified using the enzyme-linked immunosorbent assay (ELISA). Spearman's correlation analysis was employed to examine the relationship between IL-41 levels and various clinical parameters. The diagnostic potential of IL-41 was assessed using the receiver operating characteristic (ROC) curve.

Results: Serum IL-41 levels were significantly elevated in PM/DM patients with interstitial lung disease (ILD) compared to HC [1001.03 (572.95, 1604.83) pg/mL vs 361.03 (302.24, 541.06) pg/mL, P < 0.0001]. Furthermore, a significant difference was also observed in serum IL-41 levels between PM/DM patients without ILD and HC [561.81 (407.94, 827.34) pg/mL vs 361.03 (302.24, 541.06) pg/mL, P = 0.0139]. IL-41 exhibits substantial diagnostic potential for PM/DM, and its combination with lactate dehydrogenase enhances diagnostic efficacy. Moreover, IL-41 acts as an independent risk factor for the onset of PM/DM.

Conclusions: This study revealed that serum IL-41 levels are elevated in patients with PM/DM, suggesting that IL-41 could serve as a novel biomarker for the identification of these conditions.

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来源期刊

Cytokine 医学-免疫学

CiteScore

7.60

自引率

2.60%

发文量

262

审稿时长

48 days

期刊介绍： The journal Cytokine has an open access mirror journal Cytokine: X, sharing the same aims and scope, editorial team, submission system and rigorous peer review. * Devoted exclusively to the study of the molecular biology, genetics, biochemistry, immunology, genome-wide association studies, pathobiology, diagnostic and clinical applications of all known interleukins, hematopoietic factors, growth factors, cytotoxins, interferons, new cytokines, and chemokines, Cytokine provides comprehensive coverage of cytokines and their mechanisms of actions, 12 times a year by publishing original high quality refereed scientific papers from prominent investigators in both the academic and industrial sectors. We will publish 3 major types of manuscripts: 1) Original manuscripts describing research results. 2) Basic and clinical reviews describing cytokine actions and regulation. 3) Short commentaries/perspectives on recently published aspects of cytokines, pathogenesis and clinical results.