Efficient Copper‐Catalyzed, One‐Pot Synthesis of N2‐Aryl Phosphoryl 1,2,3‐Triazole 1‐Oxides

A simple and facile one‐pot process has been developed for the synthesis of N²‐aryl phosphoryl 1,2,3‐triazole 1‐oxide derivatives. This new approach utilizes simple and commercially available starting materials, operating under mild conditions. The method employs copper‐catalyzed multicomponent reaction, involving the combination of arylhydrazines, β‐ketophosphonates, and tert‐butyl nitrite. The developed protocol shows excellent functional group tolerance permitting an extensive range of substrate scope up to 92% isolated yield.