一个单一的电解槽——同时制造酰胺和α-酮酰胺：电催化和化学催化的“甜蜜融合”！

IF 2 4区化学 Q3 CHEMISTRY, MULTIDISCIPLINARY

Journal of Chemical Sciences Pub Date : 2025-10-18 DOI:10.1007/s12039-025-02440-4

Anantharaj Sengeni

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引用次数: 0

摘要

酰胺和α-酮酰胺在药物和精细化学品中无处不在。Li及其同事最近的一项研究1报道了一种模块化电解配对串联策略，该策略通过将阴极co2 - co转化与钯催化的氨基羰基化和阳极碘介导的酮酰胺化结合在一起，在单一电化学设置中产生两个家族的化合物。该系统实现了“一石二鸟”的综合。这篇评论从电化学家的角度强调了这项研究的意义。本文重点介绍了李青及其同事最近的工作。化学。Int。编辑。2025,33,e202503440)从更广阔的角度对酰胺和α-酮酰胺的模块化同步电合成进行了研究。

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A single electrolyzer-making amides and α-ketoamides together: A “sweet fusion” of electrocatalysis and chemocatalysis!

Amides and α-ketoamides are ubiquitous in drugs and fine chemicals. A recent study by Li and co-workers¹ reported a modular electrolysis-paired tandem strategy that produces both families of compounds in a single electrochemical setup by combining cathodic CO₂-to-CO conversion with palladium-catalyzed aminocarbonylation and anodic iodine-mediated ketoamidation. The system achieves “two birds with one stone” synthesis. This commentary highlights the significance of this study from an electrochemist’s perspective.

Graphical Abstract

This highlights the recent work by Qing Li and co-workers (Angew. Chem. Int. Ed. 2025, 33, e202503440) on the modular synchronous electrosynthesis of amides and α-ketoamides from a broader perspective.

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来源期刊

Journal of Chemical Sciences CHEMISTRY, MULTIDISCIPLINARY-

CiteScore

3.10

自引率

5.90%

发文量

107

审稿时长

1 months

期刊介绍： Journal of Chemical Sciences is a monthly journal published by the Indian Academy of Sciences. It formed part of the original Proceedings of the Indian Academy of Sciences – Part A, started by the Nobel Laureate Prof C V Raman in 1934, that was split in 1978 into three separate journals. It was renamed as Journal of Chemical Sciences in 2004. The journal publishes original research articles and rapid communications, covering all areas of chemical sciences. A significant feature of the journal is its special issues, brought out from time to time, devoted to conference symposia/proceedings in frontier areas of the subject, held not only in India but also in other countries.