肝癌的翻译后修饰：机制和治疗潜力。

IF 3.5 4区医学 Q2 ONCOLOGY

Medical Oncology Pub Date : 2025-10-18 DOI:10.1007/s12032-025-03079-4

Jianqi Qin, Weixiong Zhu, Zengxi Yang, Shuze Zhang, Wence Zhou

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引用次数: 0

摘要

肝细胞癌（HCC）是世界范围内常见的致死性癌症，其发病机制复杂。翻译后修饰（PTMs）对蛋白质功能、稳定性和信号传导具有重要影响，影响HCC的代谢重编程、细胞周期控制、免疫逃避和肿瘤微环境（TME）变化。最近的研究越来越多地检查了HCC中的各种PTMs，特别是磷酸化、泛素化、甲基化、糖基化、乙酰化、乳酸化和sumo化。这些修饰影响关键蛋白，如GPX4、CDK5、PHGDH、GLS1和HIF-1α，在癌症的发展、扩散和治疗耐药中发挥作用。尽管取得了进展，但在理解ptm并将其应用于临床方面仍存在挑战。本文旨在总结近年来PTM在HCC中的研究进展，评价其治疗潜力，并提出HCC的精准治疗策略。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Post-translational modifications in hepatocellular carcinoma: mechanisms and therapeutic potential.

Hepatocellular carcinoma (HCC), a prevalent and lethal cancer worldwide, is driven by complex molecular mechanisms. Post-translational modifications (PTMs) crucially influence protein function, stability, and signaling, affecting metabolic reprogramming, cell cycle control, immune evasion, and tumor microenvironment (TME) changes in HCC. Recent studies have increasingly examined various PTMs in HCC, notably phosphorylation, ubiquitination, methylation, glycosylation, acetylation, lactylation, and SUMOylation. These modifications affect key proteins like GPX4, CDK5, PHGDH, GLS1, and HIF-1α, playing roles in cancer development, spread, and treatment resistance. Despite progress, challenges remain in understanding PTMs and applying them clinically. This review aims to summarize recent PTM research in HCC, evaluate their therapeutic potential, and propose strategies for precision therapies in HCC.

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来源期刊

Medical Oncology 医学-肿瘤学

CiteScore

4.20

自引率

2.90%

发文量

259

审稿时长

1.4 months

期刊介绍： Medical Oncology (MO) communicates the results of clinical and experimental research in oncology and hematology, particularly experimental therapeutics within the fields of immunotherapy and chemotherapy. It also provides state-of-the-art reviews on clinical and experimental therapies. Topics covered include immunobiology, pathogenesis, and treatment of malignant tumors.