利用抵抗素、趋化素、颗粒前蛋白、大网膜蛋白和IL-10预测妊娠早期糖尿病。

IF 3.7 3区医学 Q2 BIOCHEMISTRY & MOLECULAR BIOLOGY

Cytokine Pub Date : 2025-10-16 DOI:10.1016/j.cyto.2025.157057

Huriye Ezveci , Sukran Dogru , Fikriye Karanfil Yaman , Pelin Bahçeci , Hatice Bedia Yildiz , Meltem Uyaner Kan , İbrahim Kilinç , Kazım Gezginç

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引用次数: 0

摘要

目的：探讨孕早期孕妇血清中促炎抵抗素、趋化素、前颗粒蛋白及抗炎脂肪因子大网膜蛋白、IL-10对妊娠期糖尿病（GDM）的预测作用。材料方法：本前瞻性病例对照研究于2023年1月至2024年7月在该大学附属医院产科进行。在妊娠早期筛查试验中收集孕妇血清样本，分析抵抗素、趋化素、颗粒前蛋白、大网膜蛋白和IL-10水平。这些病例随后被分为诊断为GDM的组和未诊断为24至28周的组。进行了临床和实验室评估。结果：该研究共包括160名孕妇。其中38例为GDM， 122例为对照。妊娠早期血清中抵抗素、趋化素、IL-10水平在GDM组与对照组间差异无统计学意义（p < 0.05）。各组间颗粒前蛋白、大网膜含量差异有统计学意义（p = 0.042, p = 0.004）。对于预测GDM，前颗粒蛋白的最佳临界值为83.5（敏感性：57.9%，特异性：63.9%,PPV: 33.3%, NPV: 83%），网膜蛋白的最佳临界值为2.5（敏感性：73.7%，特异性：58.2%,PPV: 35.4%, NPV: 87.7%）。结论：妊娠早期蛋白前和网膜蛋白水平可能有助于排除GDM，但它们缺乏足够的诊断能力。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

First-trimester prediction of gestational diabetes mellitus using resistin, chemerin, progranulin, omentin, and IL-10

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First-trimester prediction of gestational diabetes mellitus using resistin, chemerin, progranulin, omentin, and IL-10

Objective

The study aims to evaluate the prediction of gestational diabetes mellitus (GDM) by proinflammatory resistin, chemerin, and progranulin, as well as anti-inflammatory adipokines omentin and IL-10, in maternal serum during the first trimester.

Material method

This prospective case-control study was performed in the obstetric unit of the university hospital from January 2023 to July 2024. Maternal serum samples from the study cases were collected during the first-trimester screening test to analyze resistin, chemerin, progranulin, omentin, and IL-10 levels. The cases were subsequently categorized into groups diagnosed with GDM and those not diagnosed between 24 and 28 weeks. Clinical and laboratory assessments were conducted.

Results

The study included a total of 160 pregnant women. 38 of these patients had GDM, and 122 had control cases. In the serum samples taken in the first trimester, resistin, chemerin, and IL-10 levels did not create a statistically significant difference in the GDM and control groups (p > 0.05). Statistical differences were observed between the groups in progranulin and omentin levels (p = 0.042, p = 0.004, respectively). For predicting GDM, the optimum cut-off value was 83.5 for progranulin (sensitivity: 57.9 %, specificity: 63.9 %, PPV: 33.3 %, NPV: 83 %) and 2.5 for omentin (sensitivity: 73.7 %, specificity: 58.2 %, PPV: 35.4 %, NPV: 87.7 %).

Conclusion

First-trimester progranulin and omentin levels may be useful in excluding GDM, but they lack sufficient power to diagnose it.

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来源期刊

Cytokine 医学-免疫学

CiteScore

7.60

自引率

2.60%

发文量

262

审稿时长

48 days

期刊介绍： The journal Cytokine has an open access mirror journal Cytokine: X, sharing the same aims and scope, editorial team, submission system and rigorous peer review. * Devoted exclusively to the study of the molecular biology, genetics, biochemistry, immunology, genome-wide association studies, pathobiology, diagnostic and clinical applications of all known interleukins, hematopoietic factors, growth factors, cytotoxins, interferons, new cytokines, and chemokines, Cytokine provides comprehensive coverage of cytokines and their mechanisms of actions, 12 times a year by publishing original high quality refereed scientific papers from prominent investigators in both the academic and industrial sectors. We will publish 3 major types of manuscripts: 1) Original manuscripts describing research results. 2) Basic and clinical reviews describing cytokine actions and regulation. 3) Short commentaries/perspectives on recently published aspects of cytokines, pathogenesis and clinical results.