Rh（III）催化n -氨基导向C-H与α-氰基-α-重氮酯偶联合成3-氨基氨基糖-4-羧酸酯。

IF 3.6 2区化学 Q1 CHEMISTRY, ORGANIC

Journal of Organic Chemistry Pub Date : 2025-10-18 DOI:10.1021/acs.joc.5c02197

Renpeng Zhou,Xuanzhen Han,Wenjie Yue,Zhixin Wang,Jin Zhu

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引用次数: 0

摘要

反应性传播合成是一种变革性的合成实践，将反应物反应性和产品内部反应性都纳入合成设计，并将产品内部反应性的生存作为中心目标。研究了Rh（III）催化n -氨基导向C-H与α-氰基-α-重氮酯的偶联反应，合成了3-氨基吲哚-4-羧酸酯。这种合成方法的特点是保留了氮的两个杂原子位点以及氨基和酯基的内部反应性，允许进入各种开链和环拓扑结构。

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Rh(III)-Catalyzed, N-Amino-Directed C-H Coupling with α-Cyano-α-Diazoesters for the Synthesis of 3-Aminocinnoline-4-Carboxylates.

Reactivity-propagating synthesis is proposed herein as a transformative synthetic practice, with both reactant reactivity and product inner reactivity programmed into the synthetic design and survival of product inner reactivity as the central goal. Rh(III)-catalyzed, N-amino-directed C-H coupling with α-cyano-α-diazoesters has been developed for the synthesis of 3-aminocinnoline-4-carboxylates. This synthetic methodology features the survival of the product inner reactivity of two heteroatom sites of nitrogen as well as amino and ester groups, allowing versatile entry into varied open-chain and ring topology structures.

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来源期刊

Journal of Organic Chemistry 化学-有机化学

CiteScore

6.20

自引率

11.10%

发文量

1467

审稿时长

2 months

期刊介绍： Journal of Organic Chemistry welcomes original contributions of fundamental research in all branches of the theory and practice of organic chemistry. In selecting manuscripts for publication, the editors place emphasis on the quality and novelty of the work, as well as the breadth of interest to the organic chemistry community.