夜间室外人造光波长分辨测量与乳腺癌风险

IF 9.7 1区环境科学与生态学 Q1 ENVIRONMENTAL SCIENCES

Environment International Pub Date : 2025-10-17 DOI:10.1016/j.envint.2025.109871

Emma K. Quinn, Jaclyn Parks, Thomas Gagné, Christopher B. McLeod, Cheryl E. Peters, Grace Shen-Tu, Jennifer Vena, Martin Aubé, Parveen Bhatti

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引用次数: 0

摘要

夜间室外人造光（ALAN）可能通过抑制褪黑激素分泌而增加乳腺癌风险，这一效应受光强度和波长的影响。目的评估多种ALAN指标与乳腺癌风险的关系。方法：我们汇集了两项队列研究的数据（基线：2009-2016；n = 24,793名女性参与者，674例乳腺癌患者）。使用从国际空间站（2011-2013；~ 30米空间分辨率）拍摄的图像估计了住宅地址的ALAN暴露。测量包括平均视觉亮度（即亮度），平均褪黑激素抑制指数（MSI），它量化了光抑制褪黑激素的程度，以及它们的产物（平均影响MSI）。采用Cox比例风险回归，对乳腺癌危险因素和建筑环境特征进行调整，得出ALAN与乳腺癌发病率之间关联的风险比为95% %置信区间（CI）。我们还探讨了与乳腺癌亚型（浸润性导管癌、管腔癌、绝经后乳腺癌）的关系，以及参与者在睡眠时自我报告进入房间的光线。结果在整个研究人群中没有观察到令人信服的关联。在报告光线进入她们房间的女性中，观察到总体上和每个亚型的平均影响MSI与乳腺癌风险的统计学显著关联。例如，那些平均影响MSI的最高和最低百分比的人患乳腺癌的风险增加了1.53倍（95 % CI: 1.18-1.98）。讨论：我们的研究结果表明，户外ALAN与乳腺癌风险增加有关，在评估ALAN暴露时应考虑光的强度和波长。

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Wavelength-resolved measures of outdoor artificial light at night and breast cancer risk

Background

Outdoor artificial light at night (ALAN) may increase breast cancer risk by suppressing melatonin secretion, an effect influenced by light intensity and wavelength.

Objectives

We evaluated the association of multiple ALAN measures with breast cancer risk.

Methods

We pooled data from two cohort studies (baseline: 2009–2016; n = 24,793 female participants, 674 breast cancer cases). ALAN exposures at residential addresses were estimated using images taken from the International Space Station (2011–2013; ∼30-meter spatial resolution). Measures included average visual radiance (i.e., brightness), average melatonin suppression index (MSI), which quantifies the extent to which light suppresses melatonin, and their product (average impact MSI). Cox proportional hazards regression, adjusted for breast cancer risk factors and built environment features, was used to generate hazard ratios with 95 % confidence intervals (CI) for the associations between ALAN and breast cancer incidence. We also explored associations with breast cancer subtypes (invasive ductal, luminal A, postmenopausal) and among participants self-reporting light entering their rooms while sleeping.

Results

No compelling associations were observed in the overall study population. Among women reporting light entering their rooms, statistically significant associations of average impact MSI with breast cancer risk, overall and across each subtype, were observed. For example, those in the highest versus lowest tertile of average impact MSI had a 1.53-fold increased hazard of overall breast cancer (95 % CI: 1.18–1.98).

Discussion

Our findings suggest that outdoor ALAN is associated with increased risk of breast cancer and that both intensity and wavelength of light should be considered when evaluating ALAN exposures.

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来源期刊

Environment International 环境科学-环境科学

CiteScore

21.90

自引率

3.40%

发文量

734

审稿时长

2.8 months

期刊介绍： Environmental Health publishes manuscripts focusing on critical aspects of environmental and occupational medicine, including studies in toxicology and epidemiology, to illuminate the human health implications of exposure to environmental hazards. The journal adopts an open-access model and practices open peer review. It caters to scientists and practitioners across all environmental science domains, directly or indirectly impacting human health and well-being. With a commitment to enhancing the prevention of environmentally-related health risks, Environmental Health serves as a public health journal for the community and scientists engaged in matters of public health significance concerning the environment.