Adekunle Adekile, Saad A Asbeutah, Akram M Asbeutah
{"title":"科威特镰状细胞病儿童无神经症状的颅外颈内动脉多普勒超声显像","authors":"Adekunle Adekile, Saad A Asbeutah, Akram M Asbeutah","doi":"10.1002/jcu.70093","DOIUrl":null,"url":null,"abstract":"<p><strong>Purpose: </strong>The time-averaged mean of the maximum velocity (TAMMV) in both intracranialinternal carotid artery (iICA) and extracranial (eICA) and hematological variables in sickle cell disease (SCD) patients was investigated.</p><p><strong>Methods: </strong>Transcranial Doppler Imaging (TCDI) was performed with a 1-3 MHz phased-array and Linear 3.3-10 MHz transducers for both ICA. Patients were divided into three groups according to age and genotype. Blood parameters were determined using routine methods. ANOVA and linear regression analyses were done.</p><p><strong>Results: </strong>There were 59 patients, 24 males and 35 females (26 with HbSS, 29 HbSβ<sup>0</sup>, and 4 with HbSD). The average age ± SD for all patients was 10.8 ± 3.2 years. The average ± SD TAMMV for iICA was 72.4 ± 11.3 and for eICA was 63.4 ± 25.8 cm/s. There were no significant differences among patients with different genotypes. The iICA and eICA TMMAV according to age (average ± SD) for all were 72.4 ± 11.3 for iICA and 63.4 ± 25.8 for eICA. Age, platelet count, neutrophil count, LDH, and bilirubin showed no significant correlation with TAMMV in the iICA; however, it was significant in the eICA (p < 0.05).</p><p><strong>Conclusion: </strong>A significant correlation was found between age and markers of SCD severity and TAMMV in the eICA, but not with iICA. Therefore, the former might be a more important indicator of vasculopathy in our patients.</p>","PeriodicalId":15386,"journal":{"name":"Journal of Clinical Ultrasound","volume":" ","pages":""},"PeriodicalIF":1.4000,"publicationDate":"2025-10-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Extracranial Internal Carotid Artery Doppler Ultrasound Imaging Findings in Kuwaiti Children With Sickle Cell Disease and Without Neurological Symptoms.\",\"authors\":\"Adekunle Adekile, Saad A Asbeutah, Akram M Asbeutah\",\"doi\":\"10.1002/jcu.70093\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Purpose: </strong>The time-averaged mean of the maximum velocity (TAMMV) in both intracranialinternal carotid artery (iICA) and extracranial (eICA) and hematological variables in sickle cell disease (SCD) patients was investigated.</p><p><strong>Methods: </strong>Transcranial Doppler Imaging (TCDI) was performed with a 1-3 MHz phased-array and Linear 3.3-10 MHz transducers for both ICA. Patients were divided into three groups according to age and genotype. Blood parameters were determined using routine methods. ANOVA and linear regression analyses were done.</p><p><strong>Results: </strong>There were 59 patients, 24 males and 35 females (26 with HbSS, 29 HbSβ<sup>0</sup>, and 4 with HbSD). The average age ± SD for all patients was 10.8 ± 3.2 years. The average ± SD TAMMV for iICA was 72.4 ± 11.3 and for eICA was 63.4 ± 25.8 cm/s. There were no significant differences among patients with different genotypes. The iICA and eICA TMMAV according to age (average ± SD) for all were 72.4 ± 11.3 for iICA and 63.4 ± 25.8 for eICA. Age, platelet count, neutrophil count, LDH, and bilirubin showed no significant correlation with TAMMV in the iICA; however, it was significant in the eICA (p < 0.05).</p><p><strong>Conclusion: </strong>A significant correlation was found between age and markers of SCD severity and TAMMV in the eICA, but not with iICA. Therefore, the former might be a more important indicator of vasculopathy in our patients.</p>\",\"PeriodicalId\":15386,\"journal\":{\"name\":\"Journal of Clinical Ultrasound\",\"volume\":\" \",\"pages\":\"\"},\"PeriodicalIF\":1.4000,\"publicationDate\":\"2025-10-16\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Journal of Clinical Ultrasound\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.1002/jcu.70093\",\"RegionNum\":4,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q3\",\"JCRName\":\"ACOUSTICS\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of Clinical Ultrasound","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1002/jcu.70093","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"ACOUSTICS","Score":null,"Total":0}
Extracranial Internal Carotid Artery Doppler Ultrasound Imaging Findings in Kuwaiti Children With Sickle Cell Disease and Without Neurological Symptoms.
Purpose: The time-averaged mean of the maximum velocity (TAMMV) in both intracranialinternal carotid artery (iICA) and extracranial (eICA) and hematological variables in sickle cell disease (SCD) patients was investigated.
Methods: Transcranial Doppler Imaging (TCDI) was performed with a 1-3 MHz phased-array and Linear 3.3-10 MHz transducers for both ICA. Patients were divided into three groups according to age and genotype. Blood parameters were determined using routine methods. ANOVA and linear regression analyses were done.
Results: There were 59 patients, 24 males and 35 females (26 with HbSS, 29 HbSβ0, and 4 with HbSD). The average age ± SD for all patients was 10.8 ± 3.2 years. The average ± SD TAMMV for iICA was 72.4 ± 11.3 and for eICA was 63.4 ± 25.8 cm/s. There were no significant differences among patients with different genotypes. The iICA and eICA TMMAV according to age (average ± SD) for all were 72.4 ± 11.3 for iICA and 63.4 ± 25.8 for eICA. Age, platelet count, neutrophil count, LDH, and bilirubin showed no significant correlation with TAMMV in the iICA; however, it was significant in the eICA (p < 0.05).
Conclusion: A significant correlation was found between age and markers of SCD severity and TAMMV in the eICA, but not with iICA. Therefore, the former might be a more important indicator of vasculopathy in our patients.
期刊介绍：
The Journal of Clinical Ultrasound (JCU) is an international journal dedicated to the worldwide dissemination of scientific information on diagnostic and therapeutic applications of medical sonography.
The scope of the journal includes--but is not limited to--the following areas: sonography of the gastrointestinal tract, genitourinary tract, vascular system, nervous system, head and neck, chest, breast, musculoskeletal system, and other superficial structures; Doppler applications; obstetric and pediatric applications; and interventional sonography. Studies comparing sonography with other imaging modalities are encouraged, as are studies evaluating the economic impact of sonography. Also within the journal''s scope are innovations and improvements in instrumentation and examination techniques and the use of contrast agents.
JCU publishes original research articles, case reports, pictorial essays, technical notes, and letters to the editor. The journal is also dedicated to being an educational resource for its readers, through the publication of review articles and various scientific contributions from members of the editorial board and other world-renowned experts in sonography.
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