线粒体相关膜（MAMs）连接蛋白对冠状动脉钙化的影响：Heyn等人对“GRP75抑制减缓动脉钙化”的评论。动脉粥样硬化2025。

IF 5.7 2区医学 Q1 CARDIAC & CARDIOVASCULAR SYSTEMS

Atherosclerosis Pub Date : 2025-10-01 Epub Date: 2025-10-14 DOI:10.1016/j.atherosclerosis.2025.120497

Florence Gizard, Nassim Mohamedi

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引用次数: 0

摘要

Heyn等人首次提供了MAM成分葡萄糖调节蛋白75 （GRP75）在冠状动脉钙化中的关键作用的证据。其潜在机制涉及GRP75对钙化血管平滑肌细胞（SMCs） MAM完整性和基质矿化的影响。这些创新数据为动脉粥样硬化以及其他慢性和/或罕见疾病的生物医学研究开辟了新的途径。

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Influence of a mitochondria-associated membranes (MAMs) linker protein on coronary calcification: Commentary on "GRP75 inhibition attenuates arterial calcification" by Heyn J et al. Atherosclerosis 2025.

Heyn et al. provided the first evidence of a key role for a MAM component, the Glucose-regulated protein 75 (GRP75), in coronary calcification. The underlying mechanisms involve the GRP75 effect on MAM integrity and matrix mineralization in calcifying vascular smooth muscle cells (SMCs). These innovative data open up new avenues for biomedical research on atherosclerosis, and possibly other chronic and/or rare diseases.

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来源期刊

Atherosclerosis 医学-外周血管病

CiteScore

9.80

自引率

3.80%

发文量

1269

审稿时长

36 days

期刊介绍： Atherosclerosis has an open access mirror journal Atherosclerosis: X, sharing the same aims and scope, editorial team, submission system and rigorous peer review. Atherosclerosis brings together, from all sources, papers concerned with investigation on atherosclerosis, its risk factors and clinical manifestations. Atherosclerosis covers basic and translational, clinical and population research approaches to arterial and vascular biology and disease, as well as their risk factors including: disturbances of lipid and lipoprotein metabolism, diabetes and hypertension, thrombosis, and inflammation. The Editors are interested in original or review papers dealing with the pathogenesis, environmental, genetic and epigenetic basis, diagnosis or treatment of atherosclerosis and related diseases as well as their risk factors.