Monta Nakamura, Kiyoshi Kakuta, Kazuki Sato, Takeshi Wada
{"title":"更正“用恶沙磷酸法立体选择性合成核苷酸类似前药(ProTides)”","authors":"Monta Nakamura, Kiyoshi Kakuta, Kazuki Sato, Takeshi Wada","doi":"10.1021/acs.joc.5c02213","DOIUrl":null,"url":null,"abstract":"Entries 1–3 and Entry 4 were conducted on 0.03 and 0.18 mmol scales, respectively. Entry 1: Determined from the <sup>31</sup>P NMR spectrum of crude mixture. Entries 2 and 3: Determined from the <sup>31</sup>P NMR spectra after purification. Entry 4 was determined from RP-HPLC after deprotection of the DMTr group of the model compound. All reagents were added as CH<sub>3</sub>CN solution. <b>(</b><i><b>S</b></i><b>p)-4b</b> and <b>(</b><i><b>R</b></i><b>p)-4b</b> were used in Entries 1–3 and Entry 4, respectively. Determined from the <sup>31</sup>P NMR spectra of crude mixtures. Determined from the <sup>31</sup>P NMR spectra of crude mixtures. Extraction in 0.2 M citric acid aqueous solution. Determined from the <sup>31</sup>P NMR spectra after purification. Determined from the <sup>31</sup>P NMR spectra of crude mixtures. Determined from the <sup>31</sup>P NMR spectra after purification. The Supporting Information is available free of charge at https://pubs.acs.org/doi/10.1021/acs.joc.5c02213. Experimental details, HPLC profiles, copies of <sup>1</sup>H, <sup>13</sup>C, and <sup>31</sup>P NMR spectra of new compounds and final products (corrected) (PDF) Correction to “Stereoselective\nSynthesis of\nNucleotide Analog Prodrugs (ProTides) via an Oxazaphospholidine Method” <span> 3 </span><span> views </span> <span> 0 </span><span> shares </span> <span> 0 </span><span> downloads </span> Most electronic Supporting Information files are available without a subscription to ACS Web Editions. Such files may be downloaded by article for research use (if there is a public use license linked to the relevant article, that license may permit other uses). Permission may be obtained from ACS for other uses through requests via the RightsLink permission system: http://pubs.acs.org/page/copyright/permissions.html. This article has not yet been cited by other publications.","PeriodicalId":57,"journal":{"name":"Journal of Organic Chemistry","volume":"198 1","pages":""},"PeriodicalIF":3.6000,"publicationDate":"2025-10-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Correction to “Stereoselective Synthesis of Nucleotide Analog Prodrugs (ProTides) via an Oxazaphospholidine Method”\",\"authors\":\"Monta Nakamura, Kiyoshi Kakuta, Kazuki Sato, Takeshi Wada\",\"doi\":\"10.1021/acs.joc.5c02213\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"Entries 1–3 and Entry 4 were conducted on 0.03 and 0.18 mmol scales, respectively. Entry 1: Determined from the <sup>31</sup>P NMR spectrum of crude mixture. Entries 2 and 3: Determined from the <sup>31</sup>P NMR spectra after purification. Entry 4 was determined from RP-HPLC after deprotection of the DMTr group of the model compound. All reagents were added as CH<sub>3</sub>CN solution. <b>(</b><i><b>S</b></i><b>p)-4b</b> and <b>(</b><i><b>R</b></i><b>p)-4b</b> were used in Entries 1–3 and Entry 4, respectively. Determined from the <sup>31</sup>P NMR spectra of crude mixtures. Determined from the <sup>31</sup>P NMR spectra of crude mixtures. Extraction in 0.2 M citric acid aqueous solution. Determined from the <sup>31</sup>P NMR spectra after purification. Determined from the <sup>31</sup>P NMR spectra of crude mixtures. Determined from the <sup>31</sup>P NMR spectra after purification. The Supporting Information is available free of charge at https://pubs.acs.org/doi/10.1021/acs.joc.5c02213. Experimental details, HPLC profiles, copies of <sup>1</sup>H, <sup>13</sup>C, and <sup>31</sup>P NMR spectra of new compounds and final products (corrected) (PDF) Correction to “Stereoselective\\nSynthesis of\\nNucleotide Analog Prodrugs (ProTides) via an Oxazaphospholidine Method” <span> 3 </span><span> views </span> <span> 0 </span><span> shares </span> <span> 0 </span><span> downloads </span> Most electronic Supporting Information files are available without a subscription to ACS Web Editions. Such files may be downloaded by article for research use (if there is a public use license linked to the relevant article, that license may permit other uses). Permission may be obtained from ACS for other uses through requests via the RightsLink permission system: http://pubs.acs.org/page/copyright/permissions.html. 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Correction to “Stereoselective Synthesis of Nucleotide Analog Prodrugs (ProTides) via an Oxazaphospholidine Method”
Entries 1–3 and Entry 4 were conducted on 0.03 and 0.18 mmol scales, respectively. Entry 1: Determined from the 31P NMR spectrum of crude mixture. Entries 2 and 3: Determined from the 31P NMR spectra after purification. Entry 4 was determined from RP-HPLC after deprotection of the DMTr group of the model compound. All reagents were added as CH3CN solution. (Sp)-4b and (Rp)-4b were used in Entries 1–3 and Entry 4, respectively. Determined from the 31P NMR spectra of crude mixtures. Determined from the 31P NMR spectra of crude mixtures. Extraction in 0.2 M citric acid aqueous solution. Determined from the 31P NMR spectra after purification. Determined from the 31P NMR spectra of crude mixtures. Determined from the 31P NMR spectra after purification. The Supporting Information is available free of charge at https://pubs.acs.org/doi/10.1021/acs.joc.5c02213. Experimental details, HPLC profiles, copies of 1H, 13C, and 31P NMR spectra of new compounds and final products (corrected) (PDF) Correction to “Stereoselective
Synthesis of
Nucleotide Analog Prodrugs (ProTides) via an Oxazaphospholidine Method” 3 views 0 shares 0 downloads Most electronic Supporting Information files are available without a subscription to ACS Web Editions. Such files may be downloaded by article for research use (if there is a public use license linked to the relevant article, that license may permit other uses). Permission may be obtained from ACS for other uses through requests via the RightsLink permission system: http://pubs.acs.org/page/copyright/permissions.html. This article has not yet been cited by other publications.
期刊介绍:
Journal of Organic Chemistry welcomes original contributions of fundamental research in all branches of the theory and practice of organic chemistry. In selecting manuscripts for publication, the editors place emphasis on the quality and novelty of the work, as well as the breadth of interest to the organic chemistry community.