碘甲基硫鎓试剂对烯烃1,3功能化的影响。

IF 16.9 1区化学 Q1 CHEMISTRY, MULTIDISCIPLINARY

Angewandte Chemie International Edition Pub Date : 2025-10-17 DOI:10.1002/anie.202519207

Caitlin M Panos,Adrian D Matthews,Zachary K Wickens

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引用次数: 0

摘要

尽管在烯烃1,2-二官能化方面取得了巨大进展，但从烯烃中生成1,3图的类似方法仍然有限。最近，Silvi及其同事报告了一种将烯烃转化为1,3-亲电试剂的同源策略（DOI: https://doi.org/10.1002/anov.70005）。他们引入了一种新的碘甲基硫鎓盐作为甲基硫鎓自由基的前体，甲基硫鎓自由基可以在未活化的烯烃上添加。1,3-亲电试剂的取代提供了一个通用的同源烯烃双官能化平台。

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Homologative 1,3-Functionalization of Alkenes via an Iodomethyl Thianthrenium Reagent.

Despite tremendous progress in alkene 1,2-difunctionalization, analogous methods to generate 1,3-patterns from alkenes remain limited. Recently, Silvi and co-workers reported a homologative strategy to transform alkenes into 1,3-dielectrophiles (DOI: https://doi.org/10.1002/anov.70005). They introduce a novel iodomethyl thianthrenium salt as a precursor to methyl thianthrenium radical, which adds across unactivated alkenes. Substitution of the 1,3-dielectrophiles delivers a general homologative alkene difunctionalization platform.

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来源期刊

Angewandte Chemie International Edition 化学-化学综合

CiteScore

26.60

自引率

6.60%

发文量

3549

审稿时长

1.5 months

期刊介绍： Angewandte Chemie, a journal of the German Chemical Society (GDCh), maintains a leading position among scholarly journals in general chemistry with an impressive Impact Factor of 16.6 (2022 Journal Citation Reports, Clarivate, 2023). Published weekly in a reader-friendly format, it features new articles almost every day. Established in 1887, Angewandte Chemie is a prominent chemistry journal, offering a dynamic blend of Review-type articles, Highlights, Communications, and Research Articles on a weekly basis, making it unique in the field.