天然产品为基础的干预甲状腺疾病:机制和应用。

IF 3.1 4区 医学 Q2 PHARMACOLOGY & PHARMACY
Radwa H El-Akad, Ahmed H Elosaily, Noha M Gamil, Rana M Merghany, Riham A El-Shiekh, Wesam Taher Almagharbeh, Hebatollah E Eitah
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引用次数: 0

摘要

甲状腺疾病是一种广泛存在的内分泌疾病,影响着全球很大一部分人口。与特定类型或阶段甲状腺疾病相关的病理是复杂的,与各种生物功能错综复杂地联系在一起。虽然与甲状腺功能障碍相关的死亡率相对较低,但它可能导致代谢和免疫紊乱,导致患者感到相当不适。目前,有许多药物可用于治疗甲状腺疾病;然而,诸如药物毒性和延长治疗时间等问题突出了迫切需要更有效的替代品。在这篇综述中,我们进行了全面的文献检索,探讨草药和草药配方在甲状腺疾病治疗中的应用。我们的发现强调了这些自然疗法在药物发现工作中的潜力。显然,对这些药用植物的作用机制进行进一步的科学研究对于验证其传统应用至关重要。通过加强我们对这些天然产物如何发挥作用的理解,我们可以为创新的治疗策略铺平道路,这些策略可能会改善甲状腺疾病患者的预后。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Natural product-based interventions for thyroid disorders: mechanisms and applications.

Thyroid diseases are widespread endocrine disorders that affect a significant portion of the global population. The pathology associated with specific types or stages of thyroid disease is complex and intricately linked to various biological functions. While the mortality rate associated with thyroid dysfunction is relatively low, it can lead to metabolic and immunological disorders that result in considerable discomfort for affected individuals. Currently, numerous pharmaceutical options are available for managing thyroid disease; however, issues such as drug toxicity and prolonged treatment durations highlight the urgent need for more effective alternatives. In this review, we conducted a comprehensive literature search to explore the use of herbs and herbal formulations in the treatment of thyroid diseases. Our findings underscore the potential of these natural remedies in drug discovery efforts. It is evident that further scientific investigation into the mechanisms of action of these medicinal plants is crucial for validating their traditional applications. By enhancing our understanding of how these natural products function, we can pave the way for innovative therapeutic strategies that may improve outcomes for individuals suffering from thyroid disorders.

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来源期刊
CiteScore
6.20
自引率
5.60%
发文量
142
审稿时长
4-8 weeks
期刊介绍: Naunyn-Schmiedeberg''s Archives of Pharmacology was founded in 1873 by B. Naunyn, O. Schmiedeberg and E. Klebs as Archiv für experimentelle Pathologie und Pharmakologie, is the offical journal of the German Society of Experimental and Clinical Pharmacology and Toxicology (Deutsche Gesellschaft für experimentelle und klinische Pharmakologie und Toxikologie, DGPT) and the Sphingolipid Club. The journal publishes invited reviews, original articles, short communications and meeting reports and appears monthly. Naunyn-Schmiedeberg''s Archives of Pharmacology welcomes manuscripts for consideration of publication that report new and significant information on drug action and toxicity of chemical compounds. Thus, its scope covers all fields of experimental and clinical pharmacology as well as toxicology and includes studies in the fields of neuropharmacology and cardiovascular pharmacology as well as those describing drug actions at the cellular, biochemical and molecular levels. Moreover, submission of clinical trials with healthy volunteers or patients is encouraged. Short communications provide a means for rapid publication of significant findings of current interest that represent a conceptual advance in the field.
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