Radwa H El-Akad, Ahmed H Elosaily, Noha M Gamil, Rana M Merghany, Riham A El-Shiekh, Wesam Taher Almagharbeh, Hebatollah E Eitah
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Natural product-based interventions for thyroid disorders: mechanisms and applications.
Thyroid diseases are widespread endocrine disorders that affect a significant portion of the global population. The pathology associated with specific types or stages of thyroid disease is complex and intricately linked to various biological functions. While the mortality rate associated with thyroid dysfunction is relatively low, it can lead to metabolic and immunological disorders that result in considerable discomfort for affected individuals. Currently, numerous pharmaceutical options are available for managing thyroid disease; however, issues such as drug toxicity and prolonged treatment durations highlight the urgent need for more effective alternatives. In this review, we conducted a comprehensive literature search to explore the use of herbs and herbal formulations in the treatment of thyroid diseases. Our findings underscore the potential of these natural remedies in drug discovery efforts. It is evident that further scientific investigation into the mechanisms of action of these medicinal plants is crucial for validating their traditional applications. By enhancing our understanding of how these natural products function, we can pave the way for innovative therapeutic strategies that may improve outcomes for individuals suffering from thyroid disorders.
期刊介绍:
Naunyn-Schmiedeberg''s Archives of Pharmacology was founded in 1873 by B. Naunyn, O. Schmiedeberg and E. Klebs as Archiv für experimentelle Pathologie und Pharmakologie, is the offical journal of the German Society of Experimental and Clinical Pharmacology and Toxicology (Deutsche Gesellschaft für experimentelle und klinische Pharmakologie und Toxikologie, DGPT) and the Sphingolipid Club. The journal publishes invited reviews, original articles, short communications and meeting reports and appears monthly. Naunyn-Schmiedeberg''s Archives of Pharmacology welcomes manuscripts for consideration of publication that report new and significant information on drug action and toxicity of chemical compounds. Thus, its scope covers all fields of experimental and clinical pharmacology as well as toxicology and includes studies in the fields of neuropharmacology and cardiovascular pharmacology as well as those describing drug actions at the cellular, biochemical and molecular levels. Moreover, submission of clinical trials with healthy volunteers or patients is encouraged. Short communications provide a means for rapid publication of significant findings of current interest that represent a conceptual advance in the field.