远端因果偏移效应:微随机试验中时变治疗的长期效应建模。

IF 1.7 4区 数学 Q3 BIOLOGY
Biometrics Pub Date : 2025-10-08 DOI:10.1093/biomtc/ujaf134
Tianchen Qian
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引用次数: 0

摘要

微随机试验(MRTs)在优化数字干预方面发挥着至关重要的作用。在MRT中,每个参与者按顺序随机选择治疗方案数百次。虽然在mrt中测试的干预措施针对的是短期行为反应(近端结果),但它们的最终目标是推动长期行为改变(远端结果)。然而,现有的因果推理方法,如因果偏移效应,仅限于近端结果,这使得量化干预措施的长期影响具有挑战性。为了解决这一差距,我们引入了远端因果偏移效应(DCEE),这是一种量化时变治疗长期效果的新估计。DCEE对比了两种偏移政策下的远端结果,同时边缘化了大多数治疗分配,即使有大量决策点,也能实现简洁且可解释的因果模型。我们为dcee提出了两个估计器-一个具有交叉拟合,一个没有-两者都对结果模型的错误规范具有鲁棒性。我们建立了它们的渐近性质,并通过仿真验证了它们的性能。我们将我们的方法应用于HeartSteps MRT,以评估活动提示对长期习惯形成的影响。我们的研究结果表明,在研究中较早提供的提示比较晚提供的提示具有更强的长期效果,强调了干预时间在行为改变中的重要性。这项工作为从事数字干预的科学家提供了急需的工具包,以利用MRT数据评估长期因果关系。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Distal causal excursion effects: modeling long-term effects of time-varying treatments in micro-randomized trials.

Micro-randomized trials (MRTs) play a crucial role in optimizing digital interventions. In an MRT, each participant is sequentially randomized among treatment options hundreds of times. While the interventions tested in MRTs target short-term behavioral responses (proximal outcomes), their ultimate goal is to drive long-term behavior change (distal outcomes). However, existing causal inference methods, such as the causal excursion effect, are limited to proximal outcomes, making it challenging to quantify the long-term impact of interventions. To address this gap, we introduce the distal causal excursion effect (DCEE), a novel estimand that quantifies the long-term effect of time-varying treatments. The DCEE contrasts distal outcomes under two excursion policies while marginalizing over most treatment assignments, enabling a parsimonious and interpretable causal model even with a large number of decision points. We propose two estimators for the DCEE-one with cross-fitting and one without-both robust to misspecification of the outcome model. We establish their asymptotic properties and validate their performance through simulations. We apply our method to the HeartSteps MRT to assess the impact of activity prompts on long-term habit formation. Our findings suggest that prompts delivered earlier in the study have a stronger long-term effect than those delivered later, underscoring the importance of intervention timing in behavior change. This work provides the critically needed toolkit for scientists working on digital interventions to assess long-term causal effects using MRT data.

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来源期刊
Biometrics
Biometrics 生物-生物学
CiteScore
2.70
自引率
5.30%
发文量
178
审稿时长
4-8 weeks
期刊介绍: The International Biometric Society is an international society promoting the development and application of statistical and mathematical theory and methods in the biosciences, including agriculture, biomedical science and public health, ecology, environmental sciences, forestry, and allied disciplines. The Society welcomes as members statisticians, mathematicians, biological scientists, and others devoted to interdisciplinary efforts in advancing the collection and interpretation of information in the biosciences. The Society sponsors the biennial International Biometric Conference, held in sites throughout the world; through its National Groups and Regions, it also Society sponsors regional and local meetings.
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