{"title":"糖尿病患者心外膜脂肪组织体积和动脉僵硬度：METAB-CV-PWV研究","authors":"Omar Nouhou Koutcha, Sopio Tatulashvili, Nanthara Sritharan, Pierre Boutouyrie, Imen Rezgani, Marouane Boubaya, Mohamed Lamine Mariko, Lucie Allard, Meriem Sal, Coralie Bloch-Queyrat, Mohamed Zerguine, Pierre-Yves Brillet, Zouhour El Fekih, Rosa-Maria Bruno, Hélène Bihan, Emmanuel Cosson","doi":"10.1186/s12933-025-02933-z","DOIUrl":null,"url":null,"abstract":"<p><strong>Introduction: </strong>Epicardial adipose tissue (EAT) and arterial stiffness are determinants of excess risk of cardiovascular disease in persons with diabetes. This study aimed to evaluate the relationship between both of these conditions in a cohort of patients with diabetes.</p><p><strong>Materials and methods: </strong>A part retrospective, part prospective non-interventional cohort study of people living with diabetes who had (i) a computed tomography scan to measure both their coronary artery calcium score and EAT volume (proprietary prototype, GE HealthCare), and (ii) a finger-to-toe pulse wave velocity (PWV) measurement to assess arterial stiffness. The study's ClinicalTrials.gov identifier is NCT05681533.</p><p><strong>Results: </strong>A total of 345 participants (198 men, mean age (± standard deviation (SD)) 55.6 ± 12.6 years) were included; 73.6% had type 2 diabetes and 41.6% had obesity. Median duration of diabetes was 12 [interquartile range (IQR) 6-20] years. The median PWV was 8.0 [IQR 7.0-10.0] m/sec and median EAT volume was 84.9 [IQR 61.8-114.3] cm<sup>3</sup>. A positive correlation was observed between EAT volume and PWV (r = 0.37 [95% confidence interval (95%CI) 0.27-0.45], p < 0.001). EAT volume was associated with PWV tertile: specifically, participants in the first (≤ 7.0 m/sec), second, and third (> 9.0 m/sec) tertiles had, respectively, EAT volumes of 76.3 [IQR 50.3-100.6] cm<sup>3</sup>, 82.5 [IQR 64.4-107.3] cm<sup>3</sup>, and 100.2 [IQR 77.3-134.6] cm<sup>3</sup> (p < 0.001 for all three). After adjustment for age, mean blood pressure, body mass index and diabetes type, each 10 cm<sup>3</sup> increase in EAT volume was associated with a 14% increase in the probability of belonging to the third PWV tertile (odds ratio 1.14 [95%CI 1.06 - 1.21]; p < 0.001).</p><p><strong>Conclusion: </strong>EAT volume was associated with arterial stiffness in people living with diabetes. This association suggests that systemic inflammatory and metabolic mechanisms, through EAT and/or other associated ectopic adipose tissues, may contribute to an increased risk of cardiovascular disease.</p>","PeriodicalId":9374,"journal":{"name":"Cardiovascular Diabetology","volume":"24 1","pages":"400"},"PeriodicalIF":10.6000,"publicationDate":"2025-10-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12522805/pdf/","citationCount":"0","resultStr":"{\"title\":\"Epicardial adipose tissue volume and arterial stiffness in people living with diabetes: the METAB-CV-PWV study.\",\"authors\":\"Omar Nouhou Koutcha, Sopio Tatulashvili, Nanthara Sritharan, Pierre Boutouyrie, Imen Rezgani, Marouane Boubaya, Mohamed Lamine Mariko, Lucie Allard, Meriem Sal, Coralie Bloch-Queyrat, Mohamed Zerguine, Pierre-Yves Brillet, Zouhour El Fekih, Rosa-Maria Bruno, Hélène Bihan, Emmanuel Cosson\",\"doi\":\"10.1186/s12933-025-02933-z\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Introduction: </strong>Epicardial adipose tissue (EAT) and arterial stiffness are determinants of excess risk of cardiovascular disease in persons with diabetes. This study aimed to evaluate the relationship between both of these conditions in a cohort of patients with diabetes.</p><p><strong>Materials and methods: </strong>A part retrospective, part prospective non-interventional cohort study of people living with diabetes who had (i) a computed tomography scan to measure both their coronary artery calcium score and EAT volume (proprietary prototype, GE HealthCare), and (ii) a finger-to-toe pulse wave velocity (PWV) measurement to assess arterial stiffness. The study's ClinicalTrials.gov identifier is NCT05681533.</p><p><strong>Results: </strong>A total of 345 participants (198 men, mean age (± standard deviation (SD)) 55.6 ± 12.6 years) were included; 73.6% had type 2 diabetes and 41.6% had obesity. Median duration of diabetes was 12 [interquartile range (IQR) 6-20] years. The median PWV was 8.0 [IQR 7.0-10.0] m/sec and median EAT volume was 84.9 [IQR 61.8-114.3] cm<sup>3</sup>. A positive correlation was observed between EAT volume and PWV (r = 0.37 [95% confidence interval (95%CI) 0.27-0.45], p < 0.001). EAT volume was associated with PWV tertile: specifically, participants in the first (≤ 7.0 m/sec), second, and third (> 9.0 m/sec) tertiles had, respectively, EAT volumes of 76.3 [IQR 50.3-100.6] cm<sup>3</sup>, 82.5 [IQR 64.4-107.3] cm<sup>3</sup>, and 100.2 [IQR 77.3-134.6] cm<sup>3</sup> (p < 0.001 for all three). After adjustment for age, mean blood pressure, body mass index and diabetes type, each 10 cm<sup>3</sup> increase in EAT volume was associated with a 14% increase in the probability of belonging to the third PWV tertile (odds ratio 1.14 [95%CI 1.06 - 1.21]; p < 0.001).</p><p><strong>Conclusion: </strong>EAT volume was associated with arterial stiffness in people living with diabetes. This association suggests that systemic inflammatory and metabolic mechanisms, through EAT and/or other associated ectopic adipose tissues, may contribute to an increased risk of cardiovascular disease.</p>\",\"PeriodicalId\":9374,\"journal\":{\"name\":\"Cardiovascular Diabetology\",\"volume\":\"24 1\",\"pages\":\"400\"},\"PeriodicalIF\":10.6000,\"publicationDate\":\"2025-10-15\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12522805/pdf/\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Cardiovascular Diabetology\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.1186/s12933-025-02933-z\",\"RegionNum\":1,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q1\",\"JCRName\":\"CARDIAC & CARDIOVASCULAR SYSTEMS\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Cardiovascular Diabetology","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1186/s12933-025-02933-z","RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"CARDIAC & CARDIOVASCULAR SYSTEMS","Score":null,"Total":0}
Epicardial adipose tissue volume and arterial stiffness in people living with diabetes: the METAB-CV-PWV study.
Introduction: Epicardial adipose tissue (EAT) and arterial stiffness are determinants of excess risk of cardiovascular disease in persons with diabetes. This study aimed to evaluate the relationship between both of these conditions in a cohort of patients with diabetes.
Materials and methods: A part retrospective, part prospective non-interventional cohort study of people living with diabetes who had (i) a computed tomography scan to measure both their coronary artery calcium score and EAT volume (proprietary prototype, GE HealthCare), and (ii) a finger-to-toe pulse wave velocity (PWV) measurement to assess arterial stiffness. The study's ClinicalTrials.gov identifier is NCT05681533.
Results: A total of 345 participants (198 men, mean age (± standard deviation (SD)) 55.6 ± 12.6 years) were included; 73.6% had type 2 diabetes and 41.6% had obesity. Median duration of diabetes was 12 [interquartile range (IQR) 6-20] years. The median PWV was 8.0 [IQR 7.0-10.0] m/sec and median EAT volume was 84.9 [IQR 61.8-114.3] cm3. A positive correlation was observed between EAT volume and PWV (r = 0.37 [95% confidence interval (95%CI) 0.27-0.45], p < 0.001). EAT volume was associated with PWV tertile: specifically, participants in the first (≤ 7.0 m/sec), second, and third (> 9.0 m/sec) tertiles had, respectively, EAT volumes of 76.3 [IQR 50.3-100.6] cm3, 82.5 [IQR 64.4-107.3] cm3, and 100.2 [IQR 77.3-134.6] cm3 (p < 0.001 for all three). After adjustment for age, mean blood pressure, body mass index and diabetes type, each 10 cm3 increase in EAT volume was associated with a 14% increase in the probability of belonging to the third PWV tertile (odds ratio 1.14 [95%CI 1.06 - 1.21]; p < 0.001).
Conclusion: EAT volume was associated with arterial stiffness in people living with diabetes. This association suggests that systemic inflammatory and metabolic mechanisms, through EAT and/or other associated ectopic adipose tissues, may contribute to an increased risk of cardiovascular disease.
期刊介绍：
Cardiovascular Diabetology is a journal that welcomes manuscripts exploring various aspects of the relationship between diabetes, cardiovascular health, and the metabolic syndrome. We invite submissions related to clinical studies, genetic investigations, experimental research, pharmacological studies, epidemiological analyses, and molecular biology research in this field.
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