具有未观察混杂因素的连续值治疗效果的锐界。

IF 1.8 3区 生物学 Q4 MATHEMATICAL & COMPUTATIONAL BIOLOGY
Jean-Baptiste Baitairian, Bernard Sebastien, Rana Jreich, Sandrine Katsahian, Agathe Guilloux
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引用次数: 0

摘要

在因果推理中,治疗效果通常是在可忽略性或非混淆性假设下估计的,这在观察数据中往往是不现实的。通过放宽这一假设并进行敏感性分析,我们引入了新的界限并推导了平均潜在结果(APO)的置信区间——APO是评估连续值治疗或暴露效应的标准度量。我们证明了这些边界在连续灵敏度模型下是尖锐的,在某种意义上,它们给出了该模型下最小的可能区间,并提出了我们估计的双鲁棒版本。在与文献中的另一种方法(使用模拟和真实数据集)的比较分析中,我们表明,我们的方法不仅产生更清晰的边界,而且还实现了对真实APO的良好覆盖,大大减少了计算时间。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Sharp Bounds for Continuous-Valued Treatment Effects with Unobserved Confounders.

In causal inference, treatment effects are typically estimated under the ignorability, or unconfoundedness, assumption, which is often unrealistic in observational data. By relaxing this assumption and conducting a sensitivity analysis, we introduce novel bounds and derive confidence intervals for the Average Potential Outcome (APO)-a standard metric for evaluating continuous-valued treatment or exposure effects. We demonstrate that these bounds are sharp under a continuous sensitivity model, in the sense that they give the smallest possible interval under this model, and propose a doubly robust version of our estimators. In a comparative analysis with another method from the literature, using both simulated and real data sets, we show that our approach not only yields sharper bounds but also achieves good coverage of the true APO, with significantly reduced computation times.

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来源期刊
Biometrical Journal
Biometrical Journal 生物-数学与计算生物学
CiteScore
3.20
自引率
5.90%
发文量
119
审稿时长
6-12 weeks
期刊介绍: Biometrical Journal publishes papers on statistical methods and their applications in life sciences including medicine, environmental sciences and agriculture. Methodological developments should be motivated by an interesting and relevant problem from these areas. Ideally the manuscript should include a description of the problem and a section detailing the application of the new methodology to the problem. Case studies, review articles and letters to the editors are also welcome. Papers containing only extensive mathematical theory are not suitable for publication in Biometrical Journal.
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