抑郁症与自然流产风险：一项荟萃分析。

IF 3 3区心理学 Q1 PSYCHOLOGY, MULTIDISCIPLINARY

BMC Psychology Pub Date : 2025-10-14 DOI:10.1186/s40359-025-03484-4

Junxiu Liu, Mingyang Zhao, Jia Zhuan, Yanmin Song, Zhe Han, Yuanyuan Zhao, Hua Ma, Xiumei Yang

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引用次数: 0

摘要

背景：评估妇女抑郁与妊娠后自然流产（SA）风险之间的关系。方法：通过PubMed、Web of Science和Embase数据库检索相关研究。合并效应量以相对风险（RR）及其各自的95%置信区间（95% CI）表示，并使用随机效应模型进行数据分析。结果：本荟萃分析共纳入31项研究，涉及8,919,953名女性。结果显示抑郁与SA风险增加之间存在显著关联（RR = 1.34, 95% CI [1.27, 1.41], p 2 = 87%）。敏感性分析没有发现异常研究。亚组分析增强了结果的稳健性和可信度。Egger回归检验显示偏倚风险低。结论：与未患抑郁症的妇女相比，患有抑郁症的妇女怀孕后SA的风险增加，这种关联与使用抗抑郁药物无关。

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Depression with risks for spontaneous abortion: a meta-analysis.

Background: To assess the association between depression in women and the risk of spontaneous abortion (SA) after pregnancy.

Methods: Relevant studies were identified through searches of the PubMed, Web of Science, and Embase databases. The pooled effect sizes were presented as relative risk (RR) along with their respective 95% confidence intervals (95% CI), and data analysis was conducted using the random-effects model.

Results: A total of 31 studies involving 8,919,953 women were included in this meta-analysis. The results indicated a significant association between depression and increased risk of SA (RR = 1.34, 95% CI [1.27, 1.41], p < 0.001; I² = 87%). Sensitivity analysis did not identify outlier studies. Subgroup analysis enhanced the robustness and credibility of the results. Egger regression test revealed a low risk of bias.

Conclusions: Compared to women without depression, women with depression is associated with an increased risk of SA after pregnancy, an association that is unrelated to the use of antidepressant medication.

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来源期刊

BMC Psychology Psychology-Psychology (all)

CiteScore

3.90

自引率

2.80%

发文量

265

审稿时长

24 weeks

期刊介绍： BMC Psychology is an open access, peer-reviewed journal that considers manuscripts on all aspects of psychology, human behavior and the mind, including developmental, clinical, cognitive, experimental, health and social psychology, as well as personality and individual differences. The journal welcomes quantitative and qualitative research methods, including animal studies.