Hana Kahleova, Cristina Maracine, Tatiana Znayenko-Miller, Shihchen Kuo, William H Herman, Richard Holubkov, Neal D Barnard
{"title":"纯素饮食能帮助1型糖尿病患者节省胰岛素消耗吗？一项为期12周的随机临床试验的二次分析。","authors":"Hana Kahleova, Cristina Maracine, Tatiana Znayenko-Miller, Shihchen Kuo, William H Herman, Richard Holubkov, Neal D Barnard","doi":"10.1186/s40795-025-01175-2","DOIUrl":null,"url":null,"abstract":"<p><strong>Aims/hypothesis: </strong>This secondary analysis compared the effect of a vegan to a portion-controlled diet on insulin use and insulin costs in people with type 1 diabetes (T1D).</p><p><strong>Methods: </strong>Fifty-eight adults with T1D were randomly assigned to a vegan (n = 29) or a portion-controlled group (n = 29) for 12 weeks. Federal Supply Schedule pharmaceutical pricing was used to assess insulin costs.</p><p><strong>Results: </strong>Total dose of insulin decreased by 12.1 units/day in the vegan group (p = 0.007), compared to no significant change in the portion-controlled group (treatment effect - 10.7 units/day [95% CI, -21.3 to -0.2]; p = 0.046). Total insulin costs decreased by 27% ($1.08/day; p = 0.003) in the vegan group, compared to no significant change in the portion-controlled group (-$0.38/day [95% CI, -$2.13 to +$1.38]; p = 0.66).</p><p><strong>Conclusions/interpretation: </strong>This study shows that a low-fat vegan diet could reduce insulin use and insulin costs in people with T1D. Larger trials are needed to confirm these findings.</p><p><strong>Trial registration: </strong>ClinicalTrials.gov , NCT04944316, registered on June 29, 2021.</p>","PeriodicalId":36422,"journal":{"name":"BMC Nutrition","volume":"11 1","pages":"188"},"PeriodicalIF":2.2000,"publicationDate":"2025-10-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Can a vegan diet help people with type 1 diabetes save on insulin? A secondary analysis of a 12-Week randomized clinical trial.\",\"authors\":\"Hana Kahleova, Cristina Maracine, Tatiana Znayenko-Miller, Shihchen Kuo, William H Herman, Richard Holubkov, Neal D Barnard\",\"doi\":\"10.1186/s40795-025-01175-2\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Aims/hypothesis: </strong>This secondary analysis compared the effect of a vegan to a portion-controlled diet on insulin use and insulin costs in people with type 1 diabetes (T1D).</p><p><strong>Methods: </strong>Fifty-eight adults with T1D were randomly assigned to a vegan (n = 29) or a portion-controlled group (n = 29) for 12 weeks. Federal Supply Schedule pharmaceutical pricing was used to assess insulin costs.</p><p><strong>Results: </strong>Total dose of insulin decreased by 12.1 units/day in the vegan group (p = 0.007), compared to no significant change in the portion-controlled group (treatment effect - 10.7 units/day [95% CI, -21.3 to -0.2]; p = 0.046). Total insulin costs decreased by 27% ($1.08/day; p = 0.003) in the vegan group, compared to no significant change in the portion-controlled group (-$0.38/day [95% CI, -$2.13 to +$1.38]; p = 0.66).</p><p><strong>Conclusions/interpretation: </strong>This study shows that a low-fat vegan diet could reduce insulin use and insulin costs in people with T1D. Larger trials are needed to confirm these findings.</p><p><strong>Trial registration: </strong>ClinicalTrials.gov , NCT04944316, registered on June 29, 2021.</p>\",\"PeriodicalId\":36422,\"journal\":{\"name\":\"BMC Nutrition\",\"volume\":\"11 1\",\"pages\":\"188\"},\"PeriodicalIF\":2.2000,\"publicationDate\":\"2025-10-14\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"BMC Nutrition\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.1186/s40795-025-01175-2\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q3\",\"JCRName\":\"NUTRITION & DIETETICS\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"BMC Nutrition","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1186/s40795-025-01175-2","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"NUTRITION & DIETETICS","Score":null,"Total":0}
Can a vegan diet help people with type 1 diabetes save on insulin? A secondary analysis of a 12-Week randomized clinical trial.
Aims/hypothesis: This secondary analysis compared the effect of a vegan to a portion-controlled diet on insulin use and insulin costs in people with type 1 diabetes (T1D).
Methods: Fifty-eight adults with T1D were randomly assigned to a vegan (n = 29) or a portion-controlled group (n = 29) for 12 weeks. Federal Supply Schedule pharmaceutical pricing was used to assess insulin costs.
Results: Total dose of insulin decreased by 12.1 units/day in the vegan group (p = 0.007), compared to no significant change in the portion-controlled group (treatment effect - 10.7 units/day [95% CI, -21.3 to -0.2]; p = 0.046). Total insulin costs decreased by 27% ($1.08/day; p = 0.003) in the vegan group, compared to no significant change in the portion-controlled group (-$0.38/day [95% CI, -$2.13 to +$1.38]; p = 0.66).
Conclusions/interpretation: This study shows that a low-fat vegan diet could reduce insulin use and insulin costs in people with T1D. Larger trials are needed to confirm these findings.
Trial registration: ClinicalTrials.gov , NCT04944316, registered on June 29, 2021.
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