Naveed Ur Rehman Durrani, Maria Bashir Ibrahim Mohammed, Farhan Sachal Cyprian, Muhammad Naseem Khan
{"title":"产前晚期早产儿暴露于类固醇（ALPINES）和呼吸窘迫和低血糖的风险：回顾性图表回顾。","authors":"Naveed Ur Rehman Durrani, Maria Bashir Ibrahim Mohammed, Farhan Sachal Cyprian, Muhammad Naseem Khan","doi":"10.1002/ppul.71336","DOIUrl":null,"url":null,"abstract":"<p><strong>Introduction: </strong>There is a need for a better understanding of the use of antenatal steroids (ANS) in late preterm infants due to their efficacy and safety profile from existing evidence.</p><p><strong>Aims: </strong>To identify the real-world impact of ANS on short-term outcomes in late preterm infants at a quaternary care setting in Qatar.</p><p><strong>Methods: </strong>Retrospective chart review of 654 late preterm infants delivered at Sidra Medicine between 1st January 2018 and 29th February 2024. After excluding criteria, infants were categorized based on their exposure to ANS. We utilized regression models to analyze the relationship between ANS exposure and primary and secondary outcomes, including respiratory distress, Noninvasive respiratory support, hypoglycemia, and length of NICU stay, respectively, while adjusting for relevant maternal and infant characteristics.</p><p><strong>Results: </strong>Our findings reveal no significant protective effect of any ANS dosage against respiratory distress (adjusted odd ratio (aOR) 0.78; 95% CI: 0.46-1.32; p = 0.357). Conversely, ANS exposure was associated with an increased risk of hypoglycemia (aOR 1.22; 95% CI: 0.81-1.84; p = 0.350) and prolonged stay in NICU (incidence rate ratio [IRR] 1.90; 95% CI: 1.74-2.08; p < 0.001).</p><p><strong>Conclusion: </strong>Our study findings suggest a lack of protection against respiratory distress in late preterm infants with any ANS, highlighting the need for better understanding and adopting an individualized approach.</p>","PeriodicalId":19932,"journal":{"name":"Pediatric Pulmonology","volume":"60 10","pages":"e71336"},"PeriodicalIF":2.3000,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Antenatal Late Preterm Infants Exposure to Steroids (ALPINES) and Risk of Respiratory Distress and Hypoglycemia: A Retrospective Chart Review.\",\"authors\":\"Naveed Ur Rehman Durrani, Maria Bashir Ibrahim Mohammed, Farhan Sachal Cyprian, Muhammad Naseem Khan\",\"doi\":\"10.1002/ppul.71336\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Introduction: </strong>There is a need for a better understanding of the use of antenatal steroids (ANS) in late preterm infants due to their efficacy and safety profile from existing evidence.</p><p><strong>Aims: </strong>To identify the real-world impact of ANS on short-term outcomes in late preterm infants at a quaternary care setting in Qatar.</p><p><strong>Methods: </strong>Retrospective chart review of 654 late preterm infants delivered at Sidra Medicine between 1st January 2018 and 29th February 2024. After excluding criteria, infants were categorized based on their exposure to ANS. We utilized regression models to analyze the relationship between ANS exposure and primary and secondary outcomes, including respiratory distress, Noninvasive respiratory support, hypoglycemia, and length of NICU stay, respectively, while adjusting for relevant maternal and infant characteristics.</p><p><strong>Results: </strong>Our findings reveal no significant protective effect of any ANS dosage against respiratory distress (adjusted odd ratio (aOR) 0.78; 95% CI: 0.46-1.32; p = 0.357). Conversely, ANS exposure was associated with an increased risk of hypoglycemia (aOR 1.22; 95% CI: 0.81-1.84; p = 0.350) and prolonged stay in NICU (incidence rate ratio [IRR] 1.90; 95% CI: 1.74-2.08; p < 0.001).</p><p><strong>Conclusion: </strong>Our study findings suggest a lack of protection against respiratory distress in late preterm infants with any ANS, highlighting the need for better understanding and adopting an individualized approach.</p>\",\"PeriodicalId\":19932,\"journal\":{\"name\":\"Pediatric Pulmonology\",\"volume\":\"60 10\",\"pages\":\"e71336\"},\"PeriodicalIF\":2.3000,\"publicationDate\":\"2025-10-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Pediatric Pulmonology\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.1002/ppul.71336\",\"RegionNum\":3,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q1\",\"JCRName\":\"PEDIATRICS\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Pediatric Pulmonology","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1002/ppul.71336","RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"PEDIATRICS","Score":null,"Total":0}
Antenatal Late Preterm Infants Exposure to Steroids (ALPINES) and Risk of Respiratory Distress and Hypoglycemia: A Retrospective Chart Review.
Introduction: There is a need for a better understanding of the use of antenatal steroids (ANS) in late preterm infants due to their efficacy and safety profile from existing evidence.
Aims: To identify the real-world impact of ANS on short-term outcomes in late preterm infants at a quaternary care setting in Qatar.
Methods: Retrospective chart review of 654 late preterm infants delivered at Sidra Medicine between 1st January 2018 and 29th February 2024. After excluding criteria, infants were categorized based on their exposure to ANS. We utilized regression models to analyze the relationship between ANS exposure and primary and secondary outcomes, including respiratory distress, Noninvasive respiratory support, hypoglycemia, and length of NICU stay, respectively, while adjusting for relevant maternal and infant characteristics.
Results: Our findings reveal no significant protective effect of any ANS dosage against respiratory distress (adjusted odd ratio (aOR) 0.78; 95% CI: 0.46-1.32; p = 0.357). Conversely, ANS exposure was associated with an increased risk of hypoglycemia (aOR 1.22; 95% CI: 0.81-1.84; p = 0.350) and prolonged stay in NICU (incidence rate ratio [IRR] 1.90; 95% CI: 1.74-2.08; p < 0.001).
Conclusion: Our study findings suggest a lack of protection against respiratory distress in late preterm infants with any ANS, highlighting the need for better understanding and adopting an individualized approach.
期刊介绍：
Pediatric Pulmonology (PPUL) is the foremost global journal studying the respiratory system in disease and in health as it develops from intrauterine life though adolescence to adulthood. Combining explicit and informative analysis of clinical as well as basic scientific research, PPUL provides a look at the many facets of respiratory system disorders in infants and children, ranging from pathological anatomy, developmental issues, and pathophysiology to infectious disease, asthma, cystic fibrosis, and airborne toxins. Focused attention is given to the reporting of diagnostic and therapeutic methods for neonates, preschool children, and adolescents, the enduring effects of childhood respiratory diseases, and newly described infectious diseases.
PPUL concentrates on subject matters of crucial interest to specialists preparing for the Pediatric Subspecialty Examinations in the United States and other countries. With its attentive coverage and extensive clinical data, this journal is a principle source for pediatricians in practice and in training and a must have for all pediatric pulmonologists.
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