间歇性铅暴露对人类大脑进化的影响

IF 12.5 1区综合性期刊 Q1 MULTIDISCIPLINARY SCIENCES

Science Advances Pub Date : 2025-10-15 DOI:10.1126/sciadv.adr1524

Renaud Joannes-Boyau, Janaina Sena de Souza, Manish Arora, Christine Austin, Kira Westaway, Ian Moffat, Wei Wang, Wei Liao, Yingqi Zhang, Justin W. Adams, Luca Fiorenza, Flora Dérognat, Marie-Helene Moncel, Gary T. Schwartz, Marian Bailey, Filipe F. dos Santos, Gabriela D. A. Guardia, Rafael L. V. Mercuri, Pedro A. F. Galante, Aline M. A. Martins, Blake L. Tsu, Christopher A. Barnes, John Yates, Luiz Pedro Petroski, Sandra M. Sanchez-Sanchez, Jose Oviedo, Roberto H. Herai, Bernardo Lemos, Matthew Tonge, Alysson R. Muotri

{"title":"间歇性铅暴露对人类大脑进化的影响","authors":"Renaud Joannes-Boyau, Janaina Sena de Souza, Manish Arora, Christine Austin, Kira Westaway, Ian Moffat, Wei Wang, Wei Liao, Yingqi Zhang, Justin W. Adams, Luca Fiorenza, Flora Dérognat, Marie-Helene Moncel, Gary T. Schwartz, Marian Bailey, Filipe F. dos Santos, Gabriela D. A. Guardia, Rafael L. V. Mercuri, Pedro A. F. Galante, Aline M. A. Martins, Blake L. Tsu, Christopher A. Barnes, John Yates, Luiz Pedro Petroski, Sandra M. Sanchez-Sanchez, Jose Oviedo, Roberto H. Herai, Bernardo Lemos, Matthew Tonge, Alysson R. Muotri","doi":"10.1126/sciadv.adr1524","DOIUrl":null,"url":null,"abstract":"Gene-environmental interactions shape the evolution of brain architecture and function. Neuro-oncological ventral antigen 1 ( NOVA1 ) is one gene that distinguishes modern humans from extinct hominids. However, the evolutionary pressures that selected the modern NOVA1 allele remain elusive. Here, we show using fossil teeth that several hominids ( Australopithecus africanus , Paranthropus robustus , early Homo sp., Gigantopithecus blacki , Pongo sp., Homo neanderthalensis , and Homo sapiens ) were consistently exposed to lead over 2 million years, contradicting the idea that lead exposure is solely a modern phenomenon. Moreover, lead exposure on human brain organoids carrying the archaic NOVA1 variant disrupts FOXP2 expression in cortical and thalamic organoids, a gene crucial for the development of human speech and language abilities. Overall, the fossil, cellular, and molecular data support that lead exposure may have contributed to the impact of social and behavioral functioning during evolution, likely affording modern humans a survival advantage.","PeriodicalId":21609,"journal":{"name":"Science Advances","volume":"116 1","pages":""},"PeriodicalIF":12.5000,"publicationDate":"2025-10-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Impact of intermittent lead exposure on hominid brain evolution\",\"authors\":\"Renaud Joannes-Boyau, Janaina Sena de Souza, Manish Arora, Christine Austin, Kira Westaway, Ian Moffat, Wei Wang, Wei Liao, Yingqi Zhang, Justin W. Adams, Luca Fiorenza, Flora Dérognat, Marie-Helene Moncel, Gary T. Schwartz, Marian Bailey, Filipe F. dos Santos, Gabriela D. A. Guardia, Rafael L. V. Mercuri, Pedro A. F. Galante, Aline M. A. Martins, Blake L. Tsu, Christopher A. Barnes, John Yates, Luiz Pedro Petroski, Sandra M. Sanchez-Sanchez, Jose Oviedo, Roberto H. Herai, Bernardo Lemos, Matthew Tonge, Alysson R. Muotri\",\"doi\":\"10.1126/sciadv.adr1524\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"Gene-environmental interactions shape the evolution of brain architecture and function. Neuro-oncological ventral antigen 1 ( NOVA1 ) is one gene that distinguishes modern humans from extinct hominids. However, the evolutionary pressures that selected the modern NOVA1 allele remain elusive. Here, we show using fossil teeth that several hominids ( Australopithecus africanus , Paranthropus robustus , early Homo sp., Gigantopithecus blacki , Pongo sp., Homo neanderthalensis , and Homo sapiens ) were consistently exposed to lead over 2 million years, contradicting the idea that lead exposure is solely a modern phenomenon. Moreover, lead exposure on human brain organoids carrying the archaic NOVA1 variant disrupts FOXP2 expression in cortical and thalamic organoids, a gene crucial for the development of human speech and language abilities. Overall, the fossil, cellular, and molecular data support that lead exposure may have contributed to the impact of social and behavioral functioning during evolution, likely affording modern humans a survival advantage.\",\"PeriodicalId\":21609,\"journal\":{\"name\":\"Science Advances\",\"volume\":\"116 1\",\"pages\":\"\"},\"PeriodicalIF\":12.5000,\"publicationDate\":\"2025-10-15\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Science Advances\",\"FirstCategoryId\":\"103\",\"ListUrlMain\":\"https://doi.org/10.1126/sciadv.adr1524\",\"RegionNum\":1,\"RegionCategory\":\"综合性期刊\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q1\",\"JCRName\":\"MULTIDISCIPLINARY SCIENCES\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Science Advances","FirstCategoryId":"103","ListUrlMain":"https://doi.org/10.1126/sciadv.adr1524","RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"MULTIDISCIPLINARY SCIENCES","Score":null,"Total":0}

引用次数: 0

摘要

基因与环境的相互作用塑造了大脑结构和功能的进化。神经肿瘤腹侧抗原1 （NOVA1）是区分现代人与已灭绝的原始人的一个基因。然而，选择现代NOVA1等位基因的进化压力仍然难以捉摸。在这里，我们用牙齿化石证明了几个原始人（南方古猿非洲人、副人类粗壮人、早期智人、黑巨猿、庞戈人、尼安德特人和智人）在200万年的时间里一直暴露在铅下，这与铅暴露仅仅是现代现象的观点相矛盾。此外，铅暴露于携带古老NOVA1变体的人脑类器官会破坏皮层和丘脑类器官中FOXP2的表达，FOXP2是人类语言和语言能力发展的关键基因。总体而言，化石、细胞和分子数据支持铅暴露可能对进化过程中的社会和行为功能产生影响，可能为现代人提供了生存优势。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

查看原文本刊更多论文

Impact of intermittent lead exposure on hominid brain evolution

Gene-environmental interactions shape the evolution of brain architecture and function. Neuro-oncological ventral antigen 1 ( NOVA1 ) is one gene that distinguishes modern humans from extinct hominids. However, the evolutionary pressures that selected the modern NOVA1 allele remain elusive. Here, we show using fossil teeth that several hominids ( Australopithecus africanus , Paranthropus robustus , early Homo sp., Gigantopithecus blacki , Pongo sp., Homo neanderthalensis , and Homo sapiens ) were consistently exposed to lead over 2 million years, contradicting the idea that lead exposure is solely a modern phenomenon. Moreover, lead exposure on human brain organoids carrying the archaic NOVA1 variant disrupts FOXP2 expression in cortical and thalamic organoids, a gene crucial for the development of human speech and language abilities. Overall, the fossil, cellular, and molecular data support that lead exposure may have contributed to the impact of social and behavioral functioning during evolution, likely affording modern humans a survival advantage.

求助全文

通过发布文献求助，成功后即可免费获取论文全文。去求助

来源期刊

Science Advances 综合性期刊-综合性期刊

CiteScore

21.40

自引率

1.50%

发文量

1937

审稿时长

29 weeks

期刊介绍： Science Advances, an open-access journal by AAAS, publishes impactful research in diverse scientific areas. It aims for fair, fast, and expert peer review, providing freely accessible research to readers. Led by distinguished scientists, the journal supports AAAS's mission by extending Science magazine's capacity to identify and promote significant advances. Evolving digital publishing technologies play a crucial role in advancing AAAS's global mission for science communication and benefitting humankind.