Raghda E Ibrahim, Shymaa O A Khalil, Khadiga Abougabal, Alaa M Rabea, Manar M Abdel-Aziz
{"title":"2型糖尿病合并糖尿病肾病患者血清microRNA 30e-5p的表达","authors":"Raghda E Ibrahim, Shymaa O A Khalil, Khadiga Abougabal, Alaa M Rabea, Manar M Abdel-Aziz","doi":"10.55133/eji.320401","DOIUrl":null,"url":null,"abstract":"<p><p>Type 2 diabetes (T2DM) is the most prevalent form of diabetes, and frequently associated with diabetic nephropathy, a leading contributor to chronic kidney disease (CKD). The presence of microalbuminuria serves as an early marker for diabetic kidney disease (DKD). Emerging evidence suggested that alterations in microRNA (miRNA) 30e-5p expression may be linked to T2DM progression, positioning it as a potential biomarker. This study investigated the clinical relevance of miRNA 30e-5p dysregulation by assessing its expression levels in T2DM patients with and without DKD. A total of 50 participants, including 25 T2DM patients with DKD and 25 T2DM patients without DKD, were examined. Serum miRNA 30e-5p levels were quantified using real-time polymerase chain reaction. Findings revealed a significant reduction in miRNA 30e-5p expression among patients with DKD compared to those without DKD (0.25 ± 0.26 vs. 0.89 ± 0.13, p < 0.001). In conclusion, miRNA 30e-5p dysregulation appears to contribute to DKD development in Egyptian T2DM patients, suggesting its potential as a prognostic biomarker.</p>","PeriodicalId":39724,"journal":{"name":"The Egyptian journal of immunology / Egyptian Association of Immunologists","volume":"32 4","pages":"1-7"},"PeriodicalIF":0.0000,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Expression of serum microRNA 30e-5p in type 2 diabetic patients with diabetic kidney disease.\",\"authors\":\"Raghda E Ibrahim, Shymaa O A Khalil, Khadiga Abougabal, Alaa M Rabea, Manar M Abdel-Aziz\",\"doi\":\"10.55133/eji.320401\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p>Type 2 diabetes (T2DM) is the most prevalent form of diabetes, and frequently associated with diabetic nephropathy, a leading contributor to chronic kidney disease (CKD). The presence of microalbuminuria serves as an early marker for diabetic kidney disease (DKD). Emerging evidence suggested that alterations in microRNA (miRNA) 30e-5p expression may be linked to T2DM progression, positioning it as a potential biomarker. This study investigated the clinical relevance of miRNA 30e-5p dysregulation by assessing its expression levels in T2DM patients with and without DKD. A total of 50 participants, including 25 T2DM patients with DKD and 25 T2DM patients without DKD, were examined. Serum miRNA 30e-5p levels were quantified using real-time polymerase chain reaction. Findings revealed a significant reduction in miRNA 30e-5p expression among patients with DKD compared to those without DKD (0.25 ± 0.26 vs. 0.89 ± 0.13, p < 0.001). In conclusion, miRNA 30e-5p dysregulation appears to contribute to DKD development in Egyptian T2DM patients, suggesting its potential as a prognostic biomarker.</p>\",\"PeriodicalId\":39724,\"journal\":{\"name\":\"The Egyptian journal of immunology / Egyptian Association of Immunologists\",\"volume\":\"32 4\",\"pages\":\"1-7\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2025-10-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"The Egyptian journal of immunology / Egyptian Association of Immunologists\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.55133/eji.320401\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q3\",\"JCRName\":\"Medicine\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"The Egyptian journal of immunology / Egyptian Association of Immunologists","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.55133/eji.320401","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"Medicine","Score":null,"Total":0}
Expression of serum microRNA 30e-5p in type 2 diabetic patients with diabetic kidney disease.
Type 2 diabetes (T2DM) is the most prevalent form of diabetes, and frequently associated with diabetic nephropathy, a leading contributor to chronic kidney disease (CKD). The presence of microalbuminuria serves as an early marker for diabetic kidney disease (DKD). Emerging evidence suggested that alterations in microRNA (miRNA) 30e-5p expression may be linked to T2DM progression, positioning it as a potential biomarker. This study investigated the clinical relevance of miRNA 30e-5p dysregulation by assessing its expression levels in T2DM patients with and without DKD. A total of 50 participants, including 25 T2DM patients with DKD and 25 T2DM patients without DKD, were examined. Serum miRNA 30e-5p levels were quantified using real-time polymerase chain reaction. Findings revealed a significant reduction in miRNA 30e-5p expression among patients with DKD compared to those without DKD (0.25 ± 0.26 vs. 0.89 ± 0.13, p < 0.001). In conclusion, miRNA 30e-5p dysregulation appears to contribute to DKD development in Egyptian T2DM patients, suggesting its potential as a prognostic biomarker.
求助内容：
应助结果提醒方式：
京公网安备 11010802042870号
