{"title":"非典型帕金森病与自身免疫相关的免疫系统改变-一项病例对照研究。","authors":"Annamma Mathai, Sudheeran Kannoth, Vivek Nambiar, Siby Gopinath, Meena Thevarkalam, Anandkumar Anandakuttan, Sugavanan Kalingavarman, Ullas Mony, Manu Raj, Renjitha Bhaskaran","doi":"10.1080/17582024.2025.2573597","DOIUrl":null,"url":null,"abstract":"<p><strong>Background: </strong>Inflammation is known in atypical parkinsonism (AP), but the role of autoimmunity is unclear. This study evaluates immune system modifications suggesting autoimmunity in AP.</p><p><strong>Methods: </strong>Included patients with AP diagnosed at Amrita Institute of Medical Sciences, Kochi (December 2018-May 2019), and age- and sex-matched controls. Fifteen immune parameters, including T regulatory cells, RORγt, and cytokines (IL-2, IL-4, IL-6, IL-10, IL-17A, IL-21, IL-22, IL-23, TNF, IFN-γ, GM-CSF, NF-κB, TGF-β), were assessed in peripheral blood (flow cytometry and ELISA).</p><p><strong>Results: </strong>Twenty-six cases (mean age 67.8 ± 7.5 years; 16 males) and 15 controls (mean age 68.1 ± 3.5 years; 10 males) studied. Diagnoses included progressive supranuclear palsy (<i>n</i> = 15), multiple system atrophy (<i>n</i> = 1), frontotemporal dementia with parkinsonism (<i>n</i> = 2), and unspecified AP (<i>n</i> = 8). AP cases had significantly higher RORγt (<i>p</i> = 0.041), IL-6 (<i>p</i> = 0.004), TNF (<i>p</i> = 0.020), IL-10 (<i>p</i> = 0.027), and IL-4 (<i>p</i> = 0.048).</p><p><strong>Conclusions: </strong>Elevated RORγt and cytokines suggest immune dysregulation and possible autoimmune mechanisms in AP, warranting further investigation.</p>","PeriodicalId":19114,"journal":{"name":"Neurodegenerative disease management","volume":" ","pages":"1-6"},"PeriodicalIF":3.4000,"publicationDate":"2025-10-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Immune system modifications in atypical parkinsonism related to autoimmunity - a case control study.\",\"authors\":\"Annamma Mathai, Sudheeran Kannoth, Vivek Nambiar, Siby Gopinath, Meena Thevarkalam, Anandkumar Anandakuttan, Sugavanan Kalingavarman, Ullas Mony, Manu Raj, Renjitha Bhaskaran\",\"doi\":\"10.1080/17582024.2025.2573597\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Background: </strong>Inflammation is known in atypical parkinsonism (AP), but the role of autoimmunity is unclear. This study evaluates immune system modifications suggesting autoimmunity in AP.</p><p><strong>Methods: </strong>Included patients with AP diagnosed at Amrita Institute of Medical Sciences, Kochi (December 2018-May 2019), and age- and sex-matched controls. Fifteen immune parameters, including T regulatory cells, RORγt, and cytokines (IL-2, IL-4, IL-6, IL-10, IL-17A, IL-21, IL-22, IL-23, TNF, IFN-γ, GM-CSF, NF-κB, TGF-β), were assessed in peripheral blood (flow cytometry and ELISA).</p><p><strong>Results: </strong>Twenty-six cases (mean age 67.8 ± 7.5 years; 16 males) and 15 controls (mean age 68.1 ± 3.5 years; 10 males) studied. Diagnoses included progressive supranuclear palsy (<i>n</i> = 15), multiple system atrophy (<i>n</i> = 1), frontotemporal dementia with parkinsonism (<i>n</i> = 2), and unspecified AP (<i>n</i> = 8). AP cases had significantly higher RORγt (<i>p</i> = 0.041), IL-6 (<i>p</i> = 0.004), TNF (<i>p</i> = 0.020), IL-10 (<i>p</i> = 0.027), and IL-4 (<i>p</i> = 0.048).</p><p><strong>Conclusions: </strong>Elevated RORγt and cytokines suggest immune dysregulation and possible autoimmune mechanisms in AP, warranting further investigation.</p>\",\"PeriodicalId\":19114,\"journal\":{\"name\":\"Neurodegenerative disease management\",\"volume\":\" \",\"pages\":\"1-6\"},\"PeriodicalIF\":3.4000,\"publicationDate\":\"2025-10-14\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Neurodegenerative disease management\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.1080/17582024.2025.2573597\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q3\",\"JCRName\":\"CLINICAL NEUROLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Neurodegenerative disease management","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1080/17582024.2025.2573597","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"CLINICAL NEUROLOGY","Score":null,"Total":0}
Immune system modifications in atypical parkinsonism related to autoimmunity - a case control study.
Background: Inflammation is known in atypical parkinsonism (AP), but the role of autoimmunity is unclear. This study evaluates immune system modifications suggesting autoimmunity in AP.
Methods: Included patients with AP diagnosed at Amrita Institute of Medical Sciences, Kochi (December 2018-May 2019), and age- and sex-matched controls. Fifteen immune parameters, including T regulatory cells, RORγt, and cytokines (IL-2, IL-4, IL-6, IL-10, IL-17A, IL-21, IL-22, IL-23, TNF, IFN-γ, GM-CSF, NF-κB, TGF-β), were assessed in peripheral blood (flow cytometry and ELISA).
Results: Twenty-six cases (mean age 67.8 ± 7.5 years; 16 males) and 15 controls (mean age 68.1 ± 3.5 years; 10 males) studied. Diagnoses included progressive supranuclear palsy (n = 15), multiple system atrophy (n = 1), frontotemporal dementia with parkinsonism (n = 2), and unspecified AP (n = 8). AP cases had significantly higher RORγt (p = 0.041), IL-6 (p = 0.004), TNF (p = 0.020), IL-10 (p = 0.027), and IL-4 (p = 0.048).
Conclusions: Elevated RORγt and cytokines suggest immune dysregulation and possible autoimmune mechanisms in AP, warranting further investigation.
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