{"title":"MDSCs在乳腺癌中的作用：转移、脂质代谢和治疗。","authors":"Ukjin Kim, Rumela Chakrabarti","doi":"10.1158/1541-7786.MCR-24-0838","DOIUrl":null,"url":null,"abstract":"<p><p>Myeloid-derived suppressor cells (MDSCs) are one of the major contributors to the immunosuppressive microenvironment of breast cancer (BCa). MDSCs have unique mechanisms for each BCa metastasis site, and lipid metabolism acts as an energy source necessary to perform the role of MDSCs. In addition, MDSCs show different characteristics depending on BCa subtype. Currently, there is no clear understanding of MDSCs tailored to subtypes and metastatic sites in breast cancer. Here, we reviewed the biology and function of MDSCs revealed in BCa, focusing on metastasis and lipid metabolism, and discussed treatments targeting MDSCs. Understanding MDSC properties and function by BCa subtype and metastatic niche will be a prerequisite for taking the next step in subdividing BCa patients and providing customized treatment.</p>","PeriodicalId":19095,"journal":{"name":"Molecular Cancer Research","volume":" ","pages":""},"PeriodicalIF":4.7000,"publicationDate":"2025-10-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"MDSCs in breast cancer: metastasis, lipid metabolism, and therapeutics.\",\"authors\":\"Ukjin Kim, Rumela Chakrabarti\",\"doi\":\"10.1158/1541-7786.MCR-24-0838\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p>Myeloid-derived suppressor cells (MDSCs) are one of the major contributors to the immunosuppressive microenvironment of breast cancer (BCa). MDSCs have unique mechanisms for each BCa metastasis site, and lipid metabolism acts as an energy source necessary to perform the role of MDSCs. In addition, MDSCs show different characteristics depending on BCa subtype. Currently, there is no clear understanding of MDSCs tailored to subtypes and metastatic sites in breast cancer. Here, we reviewed the biology and function of MDSCs revealed in BCa, focusing on metastasis and lipid metabolism, and discussed treatments targeting MDSCs. Understanding MDSC properties and function by BCa subtype and metastatic niche will be a prerequisite for taking the next step in subdividing BCa patients and providing customized treatment.</p>\",\"PeriodicalId\":19095,\"journal\":{\"name\":\"Molecular Cancer Research\",\"volume\":\" \",\"pages\":\"\"},\"PeriodicalIF\":4.7000,\"publicationDate\":\"2025-10-14\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Molecular Cancer Research\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.1158/1541-7786.MCR-24-0838\",\"RegionNum\":2,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q2\",\"JCRName\":\"CELL BIOLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Molecular Cancer Research","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1158/1541-7786.MCR-24-0838","RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"CELL BIOLOGY","Score":null,"Total":0}
MDSCs in breast cancer: metastasis, lipid metabolism, and therapeutics.
Myeloid-derived suppressor cells (MDSCs) are one of the major contributors to the immunosuppressive microenvironment of breast cancer (BCa). MDSCs have unique mechanisms for each BCa metastasis site, and lipid metabolism acts as an energy source necessary to perform the role of MDSCs. In addition, MDSCs show different characteristics depending on BCa subtype. Currently, there is no clear understanding of MDSCs tailored to subtypes and metastatic sites in breast cancer. Here, we reviewed the biology and function of MDSCs revealed in BCa, focusing on metastasis and lipid metabolism, and discussed treatments targeting MDSCs. Understanding MDSC properties and function by BCa subtype and metastatic niche will be a prerequisite for taking the next step in subdividing BCa patients and providing customized treatment.
期刊介绍：
Molecular Cancer Research publishes articles describing novel basic cancer research discoveries of broad interest to the field. Studies must be of demonstrated significance, and the journal prioritizes analyses performed at the molecular and cellular level that reveal novel mechanistic insight into pathways and processes linked to cancer risk, development, and/or progression. Areas of emphasis include all cancer-associated pathways (including cell-cycle regulation; cell death; chromatin regulation; DNA damage and repair; gene and RNA regulation; genomics; oncogenes and tumor suppressors; signal transduction; and tumor microenvironment), in addition to studies describing new molecular mechanisms and interactions that support cancer phenotypes. For full consideration, primary research submissions must provide significant novel insight into existing pathway functions or address new hypotheses associated with cancer-relevant biologic questions.
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