Monique T Barakat, Daud Akhtar, Osamu W Yasui, Sohail Z Husain, Subhas Banerjee
{"title":"囊性纤维化携带者状态：ercp后胰腺炎的遗传易感性。","authors":"Monique T Barakat, Daud Akhtar, Osamu W Yasui, Sohail Z Husain, Subhas Banerjee","doi":"10.1016/j.gie.2025.10.012","DOIUrl":null,"url":null,"abstract":"<p><strong>Background & aims: </strong>Cystic Fibrosis (CF) is recessive and due to CFTR gene mutations. CFTR mutation heterozygotes (CF Carriers, CFC) are predisposed to CF-associated conditions, including pancreatitis. Post Endoscopic Retrograde Cholangiopancreatography (ERCP) pancreatitis (PEP) is a common adverse event following ERCP. Here we evaluate whether CFC status predisposes to PEP.</p><p><strong>Methods: </strong>This single-center retrospective cohort study evaluated CFC and presumed non-CF Carrier (N-CFC) patients undergoing index ERCP. We analyzed demographics, indications, interventions, and adverse events using descriptive statistics.</p><p><strong>Results: </strong>Among 3,057 patients, 249 were CFC. No significant differences were found in demographics or ERCP characteristics between CFC and N-CFC. However, the rate of PEP was significantly higher in CFC (17.7% vs. 4.6%, p<0.001), while other adverse events did not differ.</p><p><strong>Conclusion: </strong>CFC status appears to increase predisposition to PEP, highlighting the potential for improved pre-procedural risk assessment and prophylaxis and opportunities for further study to identify novel PEP prophylactic strategies.</p>","PeriodicalId":12542,"journal":{"name":"Gastrointestinal endoscopy","volume":" ","pages":""},"PeriodicalIF":7.5000,"publicationDate":"2025-10-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Cystic Fibrosis Carrier Status: A genetic predisposition to post-ERCP pancreatitis.\",\"authors\":\"Monique T Barakat, Daud Akhtar, Osamu W Yasui, Sohail Z Husain, Subhas Banerjee\",\"doi\":\"10.1016/j.gie.2025.10.012\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Background & aims: </strong>Cystic Fibrosis (CF) is recessive and due to CFTR gene mutations. CFTR mutation heterozygotes (CF Carriers, CFC) are predisposed to CF-associated conditions, including pancreatitis. Post Endoscopic Retrograde Cholangiopancreatography (ERCP) pancreatitis (PEP) is a common adverse event following ERCP. Here we evaluate whether CFC status predisposes to PEP.</p><p><strong>Methods: </strong>This single-center retrospective cohort study evaluated CFC and presumed non-CF Carrier (N-CFC) patients undergoing index ERCP. We analyzed demographics, indications, interventions, and adverse events using descriptive statistics.</p><p><strong>Results: </strong>Among 3,057 patients, 249 were CFC. No significant differences were found in demographics or ERCP characteristics between CFC and N-CFC. However, the rate of PEP was significantly higher in CFC (17.7% vs. 4.6%, p<0.001), while other adverse events did not differ.</p><p><strong>Conclusion: </strong>CFC status appears to increase predisposition to PEP, highlighting the potential for improved pre-procedural risk assessment and prophylaxis and opportunities for further study to identify novel PEP prophylactic strategies.</p>\",\"PeriodicalId\":12542,\"journal\":{\"name\":\"Gastrointestinal endoscopy\",\"volume\":\" \",\"pages\":\"\"},\"PeriodicalIF\":7.5000,\"publicationDate\":\"2025-10-11\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Gastrointestinal endoscopy\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.1016/j.gie.2025.10.012\",\"RegionNum\":1,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q1\",\"JCRName\":\"GASTROENTEROLOGY & HEPATOLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Gastrointestinal endoscopy","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1016/j.gie.2025.10.012","RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"GASTROENTEROLOGY & HEPATOLOGY","Score":null,"Total":0}
Cystic Fibrosis Carrier Status: A genetic predisposition to post-ERCP pancreatitis.
Background & aims: Cystic Fibrosis (CF) is recessive and due to CFTR gene mutations. CFTR mutation heterozygotes (CF Carriers, CFC) are predisposed to CF-associated conditions, including pancreatitis. Post Endoscopic Retrograde Cholangiopancreatography (ERCP) pancreatitis (PEP) is a common adverse event following ERCP. Here we evaluate whether CFC status predisposes to PEP.
Methods: This single-center retrospective cohort study evaluated CFC and presumed non-CF Carrier (N-CFC) patients undergoing index ERCP. We analyzed demographics, indications, interventions, and adverse events using descriptive statistics.
Results: Among 3,057 patients, 249 were CFC. No significant differences were found in demographics or ERCP characteristics between CFC and N-CFC. However, the rate of PEP was significantly higher in CFC (17.7% vs. 4.6%, p<0.001), while other adverse events did not differ.
Conclusion: CFC status appears to increase predisposition to PEP, highlighting the potential for improved pre-procedural risk assessment and prophylaxis and opportunities for further study to identify novel PEP prophylactic strategies.
期刊介绍：
Gastrointestinal Endoscopy is a journal publishing original, peer-reviewed articles on endoscopic procedures for studying, diagnosing, and treating digestive diseases. It covers outcomes research, prospective studies, and controlled trials of new endoscopic instruments and treatment methods. The online features include full-text articles, video and audio clips, and MEDLINE links. The journal serves as an international forum for the latest developments in the specialty, offering challenging reports from authorities worldwide. It also publishes abstracts of significant articles from other clinical publications, accompanied by expert commentaries.
求助内容：
应助结果提醒方式：
京公网安备 11010802042870号
