战火中的心脏：免疫检查点抑制剂介导的心脏毒性。

IF 5.3 2区医学 Q1 CARDIAC & CARDIOVASCULAR SYSTEMS

Canadian Journal of Cardiology Pub Date : 2025-10-11 DOI:10.1016/j.cjca.2025.10.006

Vineet Goyal, Arjun A Raghavan, Davinder S Jassal

{"title":"战火中的心脏：免疫检查点抑制剂介导的心脏毒性。","authors":"Vineet Goyal, Arjun A Raghavan, Davinder S Jassal","doi":"10.1016/j.cjca.2025.10.006","DOIUrl":null,"url":null,"abstract":"The development of immune checkpoint inhibitors (ICIs) has altered the landscape of anti-cancer therapeutics. While ICI agents have been integral in the management of a number of solid organ malignancies, their use has been associated with adverse cardiotoxic side effects including acute myocarditis, vasculitis, arrhythmia, and/or pericardial disorders. In this brief review, the pathophysiology of ICI-mediated cardiotoxicity, its clinical presentation, the diagnostic approach, and mainstays of treatment will be described.","PeriodicalId":9555,"journal":{"name":"Canadian Journal of Cardiology","volume":" ","pages":""},"PeriodicalIF":5.3000,"publicationDate":"2025-10-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Heart in the Crossfire: Immune Checkpoint Inhibitor Mediated Cardiotoxicity.\",\"authors\":\"Vineet Goyal, Arjun A Raghavan, Davinder S Jassal\",\"doi\":\"10.1016/j.cjca.2025.10.006\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"The development of immune checkpoint inhibitors (ICIs) has altered the landscape of anti-cancer therapeutics. While ICI agents have been integral in the management of a number of solid organ malignancies, their use has been associated with adverse cardiotoxic side effects including acute myocarditis, vasculitis, arrhythmia, and/or pericardial disorders. In this brief review, the pathophysiology of ICI-mediated cardiotoxicity, its clinical presentation, the diagnostic approach, and mainstays of treatment will be described.\",\"PeriodicalId\":9555,\"journal\":{\"name\":\"Canadian Journal of Cardiology\",\"volume\":\" \",\"pages\":\"\"},\"PeriodicalIF\":5.3000,\"publicationDate\":\"2025-10-11\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Canadian Journal of Cardiology\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.1016/j.cjca.2025.10.006\",\"RegionNum\":2,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q1\",\"JCRName\":\"CARDIAC & CARDIOVASCULAR SYSTEMS\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Canadian Journal of Cardiology","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1016/j.cjca.2025.10.006","RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"CARDIAC & CARDIOVASCULAR SYSTEMS","Score":null,"Total":0}

引用次数: 0

摘要

免疫检查点抑制剂（ICIs）的发展改变了抗癌治疗的前景。虽然ICI药物在许多实体器官恶性肿瘤的治疗中不可或缺，但它们的使用与不良的心脏毒性副作用相关，包括急性心肌炎、血管炎、心律失常和/或心包疾病。在这篇简短的综述中，将介绍ici介导的心脏毒性的病理生理、临床表现、诊断方法和主要治疗方法。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

查看原文本刊更多论文

Heart in the Crossfire: Immune Checkpoint Inhibitor Mediated Cardiotoxicity.

The development of immune checkpoint inhibitors (ICIs) has altered the landscape of anti-cancer therapeutics. While ICI agents have been integral in the management of a number of solid organ malignancies, their use has been associated with adverse cardiotoxic side effects including acute myocarditis, vasculitis, arrhythmia, and/or pericardial disorders. In this brief review, the pathophysiology of ICI-mediated cardiotoxicity, its clinical presentation, the diagnostic approach, and mainstays of treatment will be described.

求助全文

通过发布文献求助，成功后即可免费获取论文全文。去求助

来源期刊

Canadian Journal of Cardiology 医学-心血管系统

CiteScore

9.20

自引率

8.10%

发文量

546

审稿时长

32 days

期刊介绍： The Canadian Journal of Cardiology (CJC) is the official journal of the Canadian Cardiovascular Society (CCS). The CJC is a vehicle for the international dissemination of new knowledge in cardiology and cardiovascular science, particularly serving as the major venue for Canadian cardiovascular medicine.