Recent advancements in the synthesis of bithiazole and its derivatives for versatile medicinal applications

Directly connected 1,3-azoles are identified as sub-structures in significant naturally occurring compounds with intriguing structures as well as interesting biological activities. Amidst them, bithiazole (BT) is an uncommon structural feature of many potent naturally and biologically active compounds with diversified therapeutic efficacy. BT-based organic moieties have strengthened the efficiency of solar devices and are a promising source of light harvesting. Also, BT-based medicinal chemistry is rapidly expanding and increasing activity due to associated research and advancements. To date, no review article has explored the captivating pharmacological potential of BT as a core structure. This review marks the author’s pioneering effort to conduct a critical analysis of both the synthesis and medicinal properties of BT derivatives. The aim is to underscore this heterocyclic compound’s profound significance and practical utility in the drug discovery continuum. An overview of natural compounds containing BT, several synthesis methods, and the biological activities of some novel derivatives of the BT moiety are presented in this report.

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