Zhan Li , Shuangying Li , Shaofei Su , Lidia Morawska , Bin Jalaludin , Shyamali Dharmage , Shao Lin , Meng Gao , Juan Li , Shuanghua Xie , Enjie Zhang , Minhui Hu , Shaowen Wu , Jianhui Liu , Alexander EP Heazell , Chenghong Yin , Guang-Hui Dong , Ruixia Liu
{"title":"极端温度事件暴露与死产风险:中国全国大规模出生队列研究","authors":"Zhan Li , Shuangying Li , Shaofei Su , Lidia Morawska , Bin Jalaludin , Shyamali Dharmage , Shao Lin , Meng Gao , Juan Li , Shuanghua Xie , Enjie Zhang , Minhui Hu , Shaowen Wu , Jianhui Liu , Alexander EP Heazell , Chenghong Yin , Guang-Hui Dong , Ruixia Liu","doi":"10.1016/j.envint.2025.109854","DOIUrl":null,"url":null,"abstract":"<div><div>Extreme temperature events (ETEs) are associated with an increased risk of stillbirth. We conducted a nationwide cohort study based on China Birth Cohort Study (CBCS) across 17 provinces in 2018–2022. A set of cutoff temperature thresholds (2.5th, 5th, 7.5th, 10th, 90th, 92.5th, 95th and 97.5th percentiles of daily apparent temperature of each province during the study period) and durations (at least 2, 3, and 4 consecutive days) were utilized to define 24 distinct ETEs. We show that heatwave exposure was associated with a 36–83% increase in stillbirth. Overall, the adverse impact of cold spells on stillbirths is not significant. The effects varied across regions, and lower population density and greater medical resource were protective factors for the effects. Furthermore, when exposed to ETEs, small vulnerable newborns (SVN) are more likely to experience stillbirth. Our study highlights the need for adaptive and mitigative strategies against ETEs’ adverse effects on stillbirth.</div></div>","PeriodicalId":308,"journal":{"name":"Environment International","volume":"204 ","pages":"Article 109854"},"PeriodicalIF":9.7000,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Extreme temperature events exposure and risks of stillbirths: nationwide large birth cohort study in China\",\"authors\":\"Zhan Li , Shuangying Li , Shaofei Su , Lidia Morawska , Bin Jalaludin , Shyamali Dharmage , Shao Lin , Meng Gao , Juan Li , Shuanghua Xie , Enjie Zhang , Minhui Hu , Shaowen Wu , Jianhui Liu , Alexander EP Heazell , Chenghong Yin , Guang-Hui Dong , Ruixia Liu\",\"doi\":\"10.1016/j.envint.2025.109854\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><div>Extreme temperature events (ETEs) are associated with an increased risk of stillbirth. We conducted a nationwide cohort study based on China Birth Cohort Study (CBCS) across 17 provinces in 2018–2022. A set of cutoff temperature thresholds (2.5th, 5th, 7.5th, 10th, 90th, 92.5th, 95th and 97.5th percentiles of daily apparent temperature of each province during the study period) and durations (at least 2, 3, and 4 consecutive days) were utilized to define 24 distinct ETEs. We show that heatwave exposure was associated with a 36–83% increase in stillbirth. Overall, the adverse impact of cold spells on stillbirths is not significant. The effects varied across regions, and lower population density and greater medical resource were protective factors for the effects. Furthermore, when exposed to ETEs, small vulnerable newborns (SVN) are more likely to experience stillbirth. Our study highlights the need for adaptive and mitigative strategies against ETEs’ adverse effects on stillbirth.</div></div>\",\"PeriodicalId\":308,\"journal\":{\"name\":\"Environment International\",\"volume\":\"204 \",\"pages\":\"Article 109854\"},\"PeriodicalIF\":9.7000,\"publicationDate\":\"2025-10-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Environment International\",\"FirstCategoryId\":\"93\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S0160412025006051\",\"RegionNum\":1,\"RegionCategory\":\"环境科学与生态学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q1\",\"JCRName\":\"ENVIRONMENTAL SCIENCES\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Environment International","FirstCategoryId":"93","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S0160412025006051","RegionNum":1,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"ENVIRONMENTAL SCIENCES","Score":null,"Total":0}
Extreme temperature events exposure and risks of stillbirths: nationwide large birth cohort study in China
Extreme temperature events (ETEs) are associated with an increased risk of stillbirth. We conducted a nationwide cohort study based on China Birth Cohort Study (CBCS) across 17 provinces in 2018–2022. A set of cutoff temperature thresholds (2.5th, 5th, 7.5th, 10th, 90th, 92.5th, 95th and 97.5th percentiles of daily apparent temperature of each province during the study period) and durations (at least 2, 3, and 4 consecutive days) were utilized to define 24 distinct ETEs. We show that heatwave exposure was associated with a 36–83% increase in stillbirth. Overall, the adverse impact of cold spells on stillbirths is not significant. The effects varied across regions, and lower population density and greater medical resource were protective factors for the effects. Furthermore, when exposed to ETEs, small vulnerable newborns (SVN) are more likely to experience stillbirth. Our study highlights the need for adaptive and mitigative strategies against ETEs’ adverse effects on stillbirth.
期刊介绍:
Environmental Health publishes manuscripts focusing on critical aspects of environmental and occupational medicine, including studies in toxicology and epidemiology, to illuminate the human health implications of exposure to environmental hazards. The journal adopts an open-access model and practices open peer review.
It caters to scientists and practitioners across all environmental science domains, directly or indirectly impacting human health and well-being. With a commitment to enhancing the prevention of environmentally-related health risks, Environmental Health serves as a public health journal for the community and scientists engaged in matters of public health significance concerning the environment.