HIV感染者改用口服双重治疗的患者报告结果的性别差异:来自PROBI研究的结果

IF 1.8 Q4 INFECTIOUS DISEASES
AIDS Research and Treatment Pub Date : 2025-10-02 eCollection Date: 2025-01-01 DOI:10.1155/arat/1850783
Tristan Alain, Fabienne Marcellin, Pascal Bessonneau, Laurent Hocqueloux, Holger Muehlan, Clotilde Allavena, David Zucman, Ester Villalong-Olives, Olivier Chassany, Martin Duracinsky
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引用次数: 0

摘要

引言:社会经济、行为和社会心理因素——不仅仅是生物和激素因素——驱动HIV结果的性别差异。PROBI研究评估了HIV感染者(PLWH)从多种抗逆转录病毒治疗转向口服双重治疗的治疗可接受性、感知毒性和健康相关生活质量(HRQL)。在女性中观察到较高的停药率,促使对基于性别的HRQL差异进行分析。方法:分别在治疗切换(D0)和治疗后1、6个月(M1、M6)收集HRQL、治疗可接受性和症状负担数据。得分越高,表明症状负担(HIV-SI)越重,HRQL (PROQOL-HIV)越好,或治疗可接受性越好。使用适当的统计检验分析性别差异,并通过混合效应线性回归模型评估加班变化。结果:纳入PLWH 260例(女性占35%,n = 92),平均年龄51±12岁。与男性相比,女性更多地出生在撒哈拉以南非洲(46%对12%),受教育程度较低(20%对41%,拥有大学学位),肥胖率较高(29%对9%,BMI≥30)。虽然没有发生病毒学失败,但女性的停药率更高(15% vs. 5%)。随着时间的推移,所有参与者在症状负担(-2分)、治疗相关HRQL(+5分)、精神/认知HRQL(+4分)和治疗可接受性(+6分)方面均有所改善。然而,与男性相比,女性的认知和精神HRQL得分一直较差(平均差:-7分)。结论:虽然双重治疗提高了治疗的可接受性和HRQL,但女性的精神和认知HRQL评分仍较低。加强医患沟通可能有助于确定HRQL的变化,特别是在面临较高停药风险的妇女中。试验注册:ClinicalTrials.gov标识符:NCT04788784。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Sex Differences in Patient-Reported Outcomes Among People Living With HIV Switching to an Oral Dual Therapy: Results From the PROBI Study.

Introduction: Socioeconomic, behavioral, and psychosocial factors-beyond just biological and hormonal factors-drive sex differences in HIV outcomes. The PROBI study evaluated treatment acceptability, perceived toxicity, and health-related quality of life (HRQL) among people living with HIV (PLWH) switching from multiple antiretroviral therapy to oral dual therapy. Higher treatment discontinuation rates were observed among women, prompting this analysis of sex-based HRQL differences.

Methods: HRQL, treatment acceptability, and symptom burden data were collected at treatment switch (D0) and at 1 and 6 months afterward (M1 and M6). Higher scores indicated greater symptom burden (HIV-SI), better HRQL (PROQOL-HIV), or better treatment acceptability. Sex differences were analyzed using appropriate statistical tests, with overtime changes assessed via mixed-effects linear regression models.

Results: The study included 260 PLWH (35% women, n = 92), with a mean age of 51 ± 12 years. Compared to men, women were more frequently born in sub-Saharan Africa (46% vs. 12%), had lower educational attainment (20% vs. 41% with university degrees), and higher rates of obesity (29% vs. 9% with BMI ≥ 30). While no virologic failures occurred, treatment discontinuation was higher among women (15% vs. 5%). Over time, all participants showed improvements in symptom burden (-2 points), treatment-related HRQL (+5 points), mental/cognitive HRQL (+4 points), and treatment acceptability (+6 points). However, women consistently demonstrated worse cognitive and mental HRQL scores compared to men (mean difference: -7 points).

Conclusion: While dual therapy improved treatment acceptability and HRQL for both sexes, women maintained lower mental and cognitive HRQL scores. Enhanced patient-provider communication may help identify HRQL changes, especially among women who face higher treatment discontinuation risk.

Trial registration: ClinicalTrials.gov identifier: NCT04788784.

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来源期刊
AIDS Research and Treatment
AIDS Research and Treatment INFECTIOUS DISEASES-
CiteScore
3.10
自引率
0.00%
发文量
13
审稿时长
18 weeks
期刊介绍: AIDS Research and Treatment is a peer-reviewed, Open Access journal that publishes original research articles, review articles, and clinical studies focused on all aspects of HIV and AIDS, from the molecular basis of disease to translational and clinical research. In addition, articles relating to prevention, education, and behavior change will be considered
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