{"title":"双歧杆菌对超重或肥胖成人代谢参数的影响：一项系统综述和荟萃分析。","authors":"Junmei Huang, Hao Cheng","doi":"10.3389/fmicb.2025.1633434","DOIUrl":null,"url":null,"abstract":"<p><strong>Objective: </strong>This study endeavors to elucidate how <i>Bifidobacteria</i> supplementation affects metabolic parameters among overweight or obese populations.</p><p><strong>Methods: </strong>A systematic review and meta-analysis were carried out leveraging PubMed, Embase, Cochrane Library, and Web of Science. Merely randomized controlled trials (RCTs) were included.</p><p><strong>Results: </strong>21 RCTs were encompassed for our final analysis. <i>Bifidobacteria</i> supplementation was effective in weight management for overweight or obese patients. The experimental group receiving <i>Bifidobacteria</i> exhibited a marked decrease in weight (WMD: -0.607 kg; 95% CI: -0.910, -0.303, <i>I<sup>2</sup></i> = 11.9%) and BMI (WMD: -0.214 kg/m<sup>2</sup>; 95% CI: -0.259, -0.169, <i>I<sup>2</sup></i> = 4.1%) in contrast to the control, although the significant effect was not noted on WC. Moreover, while <i>Bifidobacteria</i> supplementation led to no marked drop in FBG or HbA1c, it improved the insulin (SMD: -0.268; 95% CI: -0.470, -0.066, <i>I<sup>2</sup></i> = 5.4%). However, there were no evident variations in TC, TG, HDL-C, or LDL-C across groups.</p><p><strong>Conclusion: </strong>Our study findings confirmed that <i>Bifidobacteria</i> contributes to a slight reduction in weight and BMI among the overweight or obese populations, making it a potential adjunctive approach for weight management. Furthermore, it may help regulate insulin levels, though its impact on hyperglycemia and hyperlipidemia remains limited.</p><p><strong>Systematic review registration: </strong>https://www.crd.york.ac.uk/PROSPERO. Registration No. CRD42025635324.</p>","PeriodicalId":12466,"journal":{"name":"Frontiers in Microbiology","volume":"16 ","pages":"1633434"},"PeriodicalIF":4.0000,"publicationDate":"2025-09-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12509062/pdf/","citationCount":"0","resultStr":"{\"title\":\"Effects of <i>Bifidobacterium</i> on metabolic parameters in overweight or obesity adults: a systematic review and meta-analysis.\",\"authors\":\"Junmei Huang, Hao Cheng\",\"doi\":\"10.3389/fmicb.2025.1633434\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Objective: </strong>This study endeavors to elucidate how <i>Bifidobacteria</i> supplementation affects metabolic parameters among overweight or obese populations.</p><p><strong>Methods: </strong>A systematic review and meta-analysis were carried out leveraging PubMed, Embase, Cochrane Library, and Web of Science. Merely randomized controlled trials (RCTs) were included.</p><p><strong>Results: </strong>21 RCTs were encompassed for our final analysis. <i>Bifidobacteria</i> supplementation was effective in weight management for overweight or obese patients. The experimental group receiving <i>Bifidobacteria</i> exhibited a marked decrease in weight (WMD: -0.607 kg; 95% CI: -0.910, -0.303, <i>I<sup>2</sup></i> = 11.9%) and BMI (WMD: -0.214 kg/m<sup>2</sup>; 95% CI: -0.259, -0.169, <i>I<sup>2</sup></i> = 4.1%) in contrast to the control, although the significant effect was not noted on WC. Moreover, while <i>Bifidobacteria</i> supplementation led to no marked drop in FBG or HbA1c, it improved the insulin (SMD: -0.268; 95% CI: -0.470, -0.066, <i>I<sup>2</sup></i> = 5.4%). However, there were no evident variations in TC, TG, HDL-C, or LDL-C across groups.</p><p><strong>Conclusion: </strong>Our study findings confirmed that <i>Bifidobacteria</i> contributes to a slight reduction in weight and BMI among the overweight or obese populations, making it a potential adjunctive approach for weight management. Furthermore, it may help regulate insulin levels, though its impact on hyperglycemia and hyperlipidemia remains limited.</p><p><strong>Systematic review registration: </strong>https://www.crd.york.ac.uk/PROSPERO. Registration No. CRD42025635324.</p>\",\"PeriodicalId\":12466,\"journal\":{\"name\":\"Frontiers in Microbiology\",\"volume\":\"16 \",\"pages\":\"1633434\"},\"PeriodicalIF\":4.0000,\"publicationDate\":\"2025-09-25\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12509062/pdf/\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Frontiers in Microbiology\",\"FirstCategoryId\":\"99\",\"ListUrlMain\":\"https://doi.org/10.3389/fmicb.2025.1633434\",\"RegionNum\":2,\"RegionCategory\":\"生物学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"2025/1/1 0:00:00\",\"PubModel\":\"eCollection\",\"JCR\":\"Q2\",\"JCRName\":\"MICROBIOLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Frontiers in Microbiology","FirstCategoryId":"99","ListUrlMain":"https://doi.org/10.3389/fmicb.2025.1633434","RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2025/1/1 0:00:00","PubModel":"eCollection","JCR":"Q2","JCRName":"MICROBIOLOGY","Score":null,"Total":0}
Effects of Bifidobacterium on metabolic parameters in overweight or obesity adults: a systematic review and meta-analysis.
Objective: This study endeavors to elucidate how Bifidobacteria supplementation affects metabolic parameters among overweight or obese populations.
Methods: A systematic review and meta-analysis were carried out leveraging PubMed, Embase, Cochrane Library, and Web of Science. Merely randomized controlled trials (RCTs) were included.
Results: 21 RCTs were encompassed for our final analysis. Bifidobacteria supplementation was effective in weight management for overweight or obese patients. The experimental group receiving Bifidobacteria exhibited a marked decrease in weight (WMD: -0.607 kg; 95% CI: -0.910, -0.303, I2 = 11.9%) and BMI (WMD: -0.214 kg/m2; 95% CI: -0.259, -0.169, I2 = 4.1%) in contrast to the control, although the significant effect was not noted on WC. Moreover, while Bifidobacteria supplementation led to no marked drop in FBG or HbA1c, it improved the insulin (SMD: -0.268; 95% CI: -0.470, -0.066, I2 = 5.4%). However, there were no evident variations in TC, TG, HDL-C, or LDL-C across groups.
Conclusion: Our study findings confirmed that Bifidobacteria contributes to a slight reduction in weight and BMI among the overweight or obese populations, making it a potential adjunctive approach for weight management. Furthermore, it may help regulate insulin levels, though its impact on hyperglycemia and hyperlipidemia remains limited.
期刊介绍：
Frontiers in Microbiology is a leading journal in its field, publishing rigorously peer-reviewed research across the entire spectrum of microbiology. Field Chief Editor Martin G. Klotz at Washington State University is supported by an outstanding Editorial Board of international researchers. This multidisciplinary open-access journal is at the forefront of disseminating and communicating scientific knowledge and impactful discoveries to researchers, academics, clinicians and the public worldwide.
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