Analytical Application of an l-Cysteine-Based Electrochemical Sensor for Quetiapine Determination in Pharmaceuticals

The electropolymerization of l-cysteine was applied for the development of sensors to determine quetiapine in tablets. The proposed sensor was characterized using electrochemical impedance spectroscopy and applicability in the analysis of quetiapine by square wave voltammetry. The electrocatalytic oxidation and pH effect of quetiapine using the sensor were investigated through cyclic voltammetry. The voltammetric peak currents, measured under optimized conditions, exhibited linearity over the quetiapine concentration range of 8.05–85.0 μmol L^–1, with a detection limit of 1.17 μmol L^–1. The proposed poly(l-cys)/GCE-based electrochemical sensor exhibited successful applicability in the selective quantification of quetiapine within pharmaceutical samples.