钴催化Isatin衍生物与芳基硼酸的对映选择性芳基化。

IF 3.6 2区化学 Q1 CHEMISTRY, ORGANIC

Journal of Organic Chemistry Pub Date : 2025-10-12 DOI:10.1021/acs.joc.5c01349

Xiang Xu,Wenxin Lu,Zhihan Zhang,Xing-Wang Wang,Qinglei Chong,Fanke Meng

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引用次数: 0

摘要

用手性膦-钴络合物催化芳烃选择性芳基化，使二取代的isatin衍生物与易于接近的芳基硼酸发生芳基化反应。这样的过程代表了一种前所未有的共催化方法，直接将各种芳基引入到isatin衍生物基序上，以98:2的er提供一系列合成有用的手性叔醇，收率高达98%。

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Cobalt-Catalyzed Enantioselective Arylation of Isatin Derivatives with Arylboronic Acids.

Catalytic enantioselective arylation of disubstituted isatin derivatives with easily accessible arylboronic acids promoted by a chiral phosphine-Co complex is presented. Such a process represents an unprecedented Co-catalyzed approach for direct introduction of a variety of aryl groups onto the isatin derivative motif, affording a range of synthetically useful chiral tertiary alcohols in up to 98% yield with 98:2 er.

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来源期刊

Journal of Organic Chemistry 化学-有机化学

CiteScore

6.20

自引率

11.10%

发文量

1467

审稿时长

2 months

期刊介绍： Journal of Organic Chemistry welcomes original contributions of fundamental research in all branches of the theory and practice of organic chemistry. In selecting manuscripts for publication, the editors place emphasis on the quality and novelty of the work, as well as the breadth of interest to the organic chemistry community.