[筛选及预防慢性病毒性肝炎]。

IF 0.7
Deutsche medizinische Wochenschrift (1946) Pub Date : 2025-10-01 Epub Date: 2025-10-10 DOI:10.1055/a-2532-6320
Markus Cornberg, Lisa Sandmann
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引用次数: 0

摘要

慢性病毒性肝炎,特别是慢性乙型和丙型肝炎,是全球肝硬化和肝细胞癌(HCC)的主要病因之一。尽管有有效的治疗选择,如针对HBV的病毒抑制核苷类似物和针对HCV的治愈性直接抗病毒治疗,但许多感染仍未被发现。世卫组织的目标是到2030年消除作为公共卫生威胁的乙肝和丙肝,目标是将新感染人数减少90%,将死亡人数减少65%。德国通过其BIS 2030战略支持这些目标,该战略强调预防、识别风险群体、教育和治疗。一个核心组成部分是筛查,以早期诊断慢性感染并及时开始治疗。本文总结了目前预防和早期发现慢性病毒性肝炎的实用建议,特别关注乙型肝炎和丙型肝炎,包括免疫功能低下个体的丁型肝炎和戊型肝炎的补充方面。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
[Screening and Prevention of Chronic Viral Hepatitis].

Chronic viral hepatitis, particularly chronic hepatitis B and C, is among the leading global causes of liver cirrhosis and hepatocellular carcinoma (HCC). Despite effective treatment options such as virus suppressive nucleos(t)ide analogues for HBV and curative direct acting antiviral therapies for HCV, many infections remain undetected. The WHO aims to eliminate hepatitis B and C as public health threats by 2030, targeting a 90% reduction in new infections and a 65% reduction in deaths. Germany supports these objectives through its BIS 2030 strategy, which emphasizes prevention, identification of at-risk groups, education, and treatment. A central component is screening to diagnose chronic infections early and initiate therapy promptly. This article summarizes practical current recommendations for the prevention and early detection of chronic viral hepatitis, with a particular focus on hepatitis B and hepatitis C, including complementary aspects regarding hepatitis D and hepatitis E in immunocompromised individuals.

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