Influence of Cannabidiol Use on Visual Function and Optical Quality: A Randomized Controlled Trial.

Purpose: To study the influence of different concentrations of vaporized cannabidiol (CBD; 0%, 15%, and 30%) on visual function and optical quality.

Methods: A randomized, crossover, double-blind, placebo-controlled, experimental study was conducted. A total of 30 participants with a mean age of 26.0 ± 6.3 years completed the study. Placebo (0 mg of CBD), 15% (16 mg of CBD), and 30% (32 mg of CBD) concentrations of CBD were employed. Visual function was evaluated through various tests, including pupil size, static and dynamic visual acuity, contrast sensitivity, dot motion detection, visual disturbance index (VDI), and stereoacuity. Optical quality was assessed by log(s), modulation transfer function (MTF) cutoff, objective scattering index (OSI), and Strehl ratio. Self-perceived visual effects were also recorded.

Results: There was no significant impairment of static and dynamic visual acuity. Contrast sensitivity was unaffected by CBD use. Mean dot motion detection showed no differences among the three concentrations. In optical quality, none of the parameters worsened under CBD use. No changes were observed for the VDI. In addition, no deterioration was observed for stereoacuity at distance or near. No changes in pupil size were found after CBD consumption.

Conclusions: This non-psychotropic CBD did not appear to adversely affect vision and seems to be a safe substance in the short term at the concentrations assessed.

Translational relevance: The use of this cannabinoid would not be dangerous for tasks that rely heavily on vision. This study could be useful and helpful for evidence-based decision-making for public health policy on its use.