水飞蓟水溶性水飞蓟素纳米晶的高效合成及其抗菌和细胞毒性评价。

IF 3.9 2区综合性期刊 Q1 MULTIDISCIPLINARY SCIENCES

Scientific Reports Pub Date : 2025-10-10 DOI:10.1038/s41598-025-19501-w

Iman Sirvani, Zahra Sabouri, Asma Mostafapour, Majid Darroudi

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引用次数: 0

摘要

以水飞蓟提取物为原料，采用溶剂蒸发法制备了水溶性水飞蓟素纳米晶。采用XRD、FESEM/TEM、EDX、FT-IR、UV-Vis等方法对合成的水飞蓟素NCs进行了表征。水飞蓟素纳米材料的XRD谱图显示为非晶结构。水飞蓟素NCs的FESEM和TEM图像显示为球形，尺寸约为23.14 nm。FTIR光谱还揭示了水飞蓟素和水飞蓟素NCs中官能团的存在。水飞蓟素NCs的紫外可见光谱在230 nm和285 nm范围内呈现较强的吸收带。MTT实验结果表明，水飞蓟素NCs对肿瘤MDA-MB-231细胞的毒性最小，IC50量为420.3µg/mL。此外，根据抗菌试验结果，水飞蓟素NCs对金黄色葡萄球菌（ATCC）和大肠杆菌（ATCC）的抑菌效果优于临床菌株。

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Efficient synthesis of aqueous soluble Silymarin nanocrystals from Silybum marianum and assessment of their antibacterial and cytotoxicity insights.

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Efficient synthesis of aqueous soluble Silymarin nanocrystals from Silybum marianum and assessment of their antibacterial and cytotoxicity insights.

In this paper, aqueous-soluble silymarin nanocrystals (NCs) were prepared using Silybum marianum extract via the solvent evaporation method. The synthesized silymarin NCs were identified by XRD, FESEM/TEM, EDX, FT-IR, and UV-Vis procedures. The XRD pattern of silymarin NCs has shown amorphous structures. FESEM and TEM images of silymarin NCs exhibited spherical shapes with a size of about 23.14 nm. Also, the FTIR spectra revealed the presence of the functional groups in silymarin and silymarin NCs. The UV-Vis results of silymarin NCs donated strong absorption bands in the range of 230 and 285 nm. The results of the MTT assay indicated that silymarin NCs had minimum toxicity on cancer MDA-MB-231 cells with an IC₅₀ amount of 420.3 µg/mL. Also, according to the results of the antibacterial tests, silymarin NCs exhibited superior efficacy against Staphylococcus aureus (ATCC) and Escherichia coli (ATCC) in comparison with clinical strains.

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来源期刊

Scientific Reports Natural Science Disciplines-

CiteScore

7.50

自引率

4.30%

发文量

19567

审稿时长

3.9 months

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